Diabetes pp 139-154 | Cite as

Glycemic Variability in Type 2 Diabetes Mellitus

Oxidative Stress and Macrovascular Complications
  • Eric L. Johnson
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


Diabetes mellitus is a world-wide health issue with potential for significant negative health outcomes, including microvascular and macrovascular complications. The relationship of hemoglobin HbA1c and other glycosylation end products (AGEs) to these complications, particularly microvascular disease, is well understood. More recent evidence suggests that glycemic variability may be associated with diabetes macrovascular complications. As HbA1c is better representative of average glucose levels and does not account as well for glycemic variability, hence new methods to assess and treat this variability is needed to reduce incidence of complications. In this chapter, the relationship of glycemic control to diabetes complications will be explored with focus on the mechanisms of tissue damage from this variability along with the oxidative stress. Additionally, treatment strategies to optimize HbA1c and glycemic variability with the goal of reducing risk of complications in persons with diabetes are reviewed.


Glycemic Control Human Insulin Insulin Glargine Continuous Glucose Monitoring Insulin Aspart 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2013

Authors and Affiliations

  • Eric L. Johnson
    • 1
  1. 1.Department of Family and Community MedicineUniversity of North DakotaGrand ForksUSA

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