Nausea and Vomiting

  • Pernille H. Hansen
  • Jesper Palshof
  • Jørn Herrstedt
Chapter

Abstract

Despite the fact that research in the mechanism of vomiting goes back more than 300 years, there are still major gaps in our knowledge. The first report of the clinical use of an antineoplastic drug was published in 1942, but it was not until cisplatin, the most emetogenic of all drugs, was approved in 1978, the necessity of focusing on antiemetic research became evident.

This chapter will focus on the biological basis of nausea and vomiting from the time of the very simple animal experiments, suggesting the existence of a vomiting center, to current research methodology enabling precise subdivision of receptors involved in the emetic reflex arch.

Keywords

Morphine Histamine Doxorubicin Cyclophosphamide Acetylcholine 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Pernille H. Hansen
    • 1
  • Jesper Palshof
    • 2
  • Jørn Herrstedt
    • 3
  1. 1.Laboratory of Neuropsychiatry/Molecular Neuropharmacology Laboratory, Department of Neuroscience and PharmacologyUniversity of CopenhagenCopenhagenDenmark
  2. 2.Department of Oncology, Herlev HospitalUniversity of CopenhagenCopenhagenDenmark
  3. 3.Department of OncologyOdense University Hospital, and University of Southern DenmarkOdense CDenmark

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