Borrelial Complement-Binding Proteins

  • Peter Kraiczy
  • Reinhard Wallich


Spirochetes causing Lyme disease or relapsing fever exploit an array of sophisticated means to establish infection and to combat innate and adaptive immune responses of the human host. One central immune escape mechanism of serum-resistant spirochetes involves the inactivation of host complement attack through binding of distinct complement regulatory proteins, including factor H (CFH), factor H-like protein 1 (FHL1), factor H-related protein 1 (CFHR1), CFHR2, CFHR5, C4b-binding protein (C4Bp), and/or C1 esterase inhibitor (C1-Inh) to the cell surface (Fig. 4.1) (Alitalo et al. 2001; Bhide et al. 2009; Grosskinsky et al. 2009; Haupt et al. 2007; Hellwage et al. 2001; Kraiczy et al. 2001a, b; McDowell et al. 2003a; Pietikainen et al. 2010; Rossmann et al. 2007; Schott et al. 2010; Siegel et al. 2010; Stevenson et al. 2002; Meri et al. 2006).


Lyme Disease Complement Regulator Lectin Pathway Relapse Fever Lyme Disease Spirochete 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We want to thank all of our colleagues whose research has contributed to an increased understanding of the role of borrelial complement-binding proteins in immune evasion of these emerging pathogens. Many thanks to Brian Stevenson for critical review of the manuscript and fruitful discussions, and Arno Koenigs for help with the graphics. Research in the authors’ labs was supported by the Deutsche Forschungsgemeinschaft (Kr3383/1-2, Wa533/7-1, and Wa533/8-1).


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Institute of Medical Microbiology and Infection ControlUniversity Hospital of Frankfurt am MainFrankfurt/MainGermany
  2. 2.Institute of ImmunologyUniversity of HeidelbergHeidelbergGermany

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