Abstract
Cardiac Safety is an important consideration in drug development. This chapter focuses on interval data derived from the 12-lead surface electrocardiogram (ECG) and graphical approaches that enable a better understanding of the data. A motivating example for the link between ECG interval data and cardiac safety is followed by an orientation to the intervals and their relationship to cardiac function. QT interval corrections for heart rate are discussed as are types of data collection. Sample data that are publically available are used in many of the examples from the thorough QT trial presented. Graphics are used to demonstrate some of the attributes of these trial designs such as time matching and use of active controls.
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© 2012 Springer Science+Business Media, New York
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Anziano, R.J. (2012). Cardiac Safety. In: Krause, A., O'Connell, M. (eds) A Picture is Worth a Thousand Tables. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-5329-1_18
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DOI: https://doi.org/10.1007/978-1-4614-5329-1_18
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Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4614-5329-1
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