Oral Cytology pp 109-123 | Cite as

The Role of Ploidy Analysis in Oral Cytology

  • Torsten W. Remmerbach


Squamous cell carcinomas of the oral cavity are among the ten most common cancers in the world, accounting for approximately 3–5 % of all malignancies. In Germany, approximately 4,100 new cases of oral cancer in males and 1,000 in females were encountered annually during the last decade. In spite of great surgical, chemo- and radiotherapeutic efforts the 5-year-survival-rate could not be decreased so far, being still less than 45 % in Europe. However oral cancer can be cured, if detected and treated early enough. One should, furthermore, emphasize the importance of an early diagnosis of oral cancers in order to reduce their disappointingly high morbidity and mortality. Until now, scalpel biopsy with histological assessment seemed to be the only accepted method to definitely evaluate suspicious oral lesions. However, literature shows insufficient inter- and intra-individual reproducibility of histological grading epithelial dysplasia and unequivocally identifying carcinoma in situ. Unfortunately, scalpel biopsies are not an ideal screening tool for the early identification of oral cancer because of their invasiveness; alternatively a useful diagnostic screening procedure could be easily obtained oral smears with subsequent cytological examination. Adjuvant methods e.g. image DNA cytometry or multimodal cell analysis may also help to increase the diagnostic accuracy and may lead to safe, quick and valid results of oral brush biopsies.


Oral Cancer Oral Squamous Cell Carcinoma Integrate Optical Density Stem Line Image Cytometry 
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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Oral Medicine Unit, Department of Oral, Maxillofacial and Facial Plastic SurgeryUniversity of LeipzigLeipzigGermany

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