Sarcoidosis is a systemic granulomatous disease of unknown causes that can afflict virtually every organ system in the body. The infiltrating granulomas and chronic persistent inflammation in tissues and organs are presumed to be the consequence of an abnormal systemic and/or local immune response to either one or multiple unknown antigens in genetically susceptible adolescents and adults. The precise etiology of sarcoidosis has eluded the best minds in Medicine for over a century but that does not preclude our ability to diagnose sarcoidosis in a timely manner. The following two cases are representative of the difficult challenges frequently encountered in the diagnosis and management of this disease with protean and seemingly unrelated clinical manifestations.


Irritable Bowel Syndrome Pulmonary Arterial Hypertension Cardiac Sarcoidosis Pulmonary Sarcoidosis Noncaseating Granuloma 
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  1. 1.
    Baughman RP, Culver DA, Judson MA. A concise review pulmonary sarcoidosis. Am J Respir Crit Care Med. 2011;183:573–5812.PubMedCrossRefGoogle Scholar
  2. 2.
    Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS executive committee, February 1999. Am J Respir Crit Care Med. 1999;160(2):736–55.Google Scholar
  3. 3.
    Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007;357(21):2153–65.PubMedCrossRefGoogle Scholar
  4. 4.
    Tremblay A, Stather DR, MacEachern P, Khalil M, Field SK. A randomized controlled trial of standard vs endobronchial ultrasound-guided transbronchial needle aspiration in patient with suspected sarcoidosis. Chest. 2009;136:340–6.PubMedCrossRefGoogle Scholar
  5. 5.
    Morgenthau AS, Iannuzzi MC. Recent advances in sarcoidosis. Chest. 2011;139(1):174–82.PubMedCrossRefGoogle Scholar
  6. 6.
    Youssef G, Beanlands RSB, Birnie DH, Nery PB. Cardiac sarcoidosis: applications of imaging in diagnosis and directing treatment. Heart. 2011;97:2078–87.PubMedCrossRefGoogle Scholar
  7. 7.
    Lodha S, Sanchez M, Prystowsky S. Sarcoidosis of the skin: a review for the pulmonologist. Chest. 2009;136:583–96.PubMedCrossRefGoogle Scholar
  8. 8.
    Demirci H, Christianson MD. Orbital and adnexal involvement in sarcoidosis: analysis of clinical features and systemic disease in 30 cases. Am J Ophthalmol. 2011;151:1074–80.PubMedCrossRefGoogle Scholar
  9. 9.
    Terushkin V, Stern BJ, Judson MA, Hagiwara M, Pramanik B, Sanchez M, Prystowsky S. Neurosarcoidosis: presentations and management. Neurologist. 2010;16:2–15.PubMedCrossRefGoogle Scholar
  10. 10.
    Cowan CL. Review for disease of the year: differential diagnosis of ocular sarcoidosis. Ocul Immunol Inflamm. 2010;18(6):442–51.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.University of CaliforniaDavisUSA
  2. 2.Division of Pulmonary, Department of Internal Medicine Critical Care and Sleep MedicineUC Davis Medical CenterSacramentoUSA
  3. 3.Mather VA Medical CenterNorthern California Health Care System (NCHCS)MatherUSA

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