Sarcoidosis is a systemic granulomatous disease of unknown causes that can afflict virtually every organ system in the body. The infiltrating granulomas and chronic persistent inflammation in tissues and organs are presumed to be the consequence of an abnormal systemic and/or local immune response to either one or multiple unknown antigens in genetically susceptible adolescents and adults. The precise etiology of sarcoidosis has eluded the best minds in Medicine for over a century but that does not preclude our ability to diagnose sarcoidosis in a timely manner. The following two cases are representative of the difficult challenges frequently encountered in the diagnosis and management of this disease with protean and seemingly unrelated clinical manifestations.
KeywordsFatigue Lymphoma Tuberculosis Methotrexate Meningitis
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