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The Pathology of Chronic Inflammatory Bowel Disease

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Pediatric Inflammatory Bowel Disease

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Abstract

This chapter reviews the major gross and microscopic features of ulcerative colitis and Crohn’s disease, with an emphasis on the earliest histologic features of these conditions and their distinction from acute self-limited colitis and artifactual changes, especially those encountered in biopsy material. In addition, particular attention is paid to features that can be considered “atypical” in patients with ulcerative colitis, namely rectal sparing and patchy involvement of the bowel mucosa, “backwash ileitis,” involvement of the upper GI tract, peri-appendiceal inflammation, fulminant and indeterminate colitis and pouchitis.

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  1. Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA, 19104, USA

    Pierre Russo MD

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Editors and Affiliations

  1. Perelman School of Medicine, The Children’s Hospital of Philadelphia, University of Pennsylvania, 34th St. & Civic Ctr. Blvd., Philadelphia, 19104, Pennsylvania, USA

    Petar Mamula

  2. School of Medicine--Greenville, Pediatric Gastroenterology & Nutrition, University of South Carolina, 200 Patewood Drive, Suite A-140, Greenville, 29615, South Carolina, USA

    Jonathan E. Markowitz

  3. Perelman School of Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, 34th St. & Civic Ctr. Blvd., Philadelphia, 19104, Pennsylvania, USA

    Robert N. Baldassano

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Russo, P. (2013). The Pathology of Chronic Inflammatory Bowel Disease. In: Mamula, P., Markowitz, J., Baldassano, R. (eds) Pediatric Inflammatory Bowel Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5061-0_21

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