Undifferentiated Pleomorphic Sarcoma (UPS; Malignant Fibrous Histiocytoma: MFH) and Myxofibrosarcoma

  • Murray F. Brennan
  • Cristina R. Antonescu
  • Robert G. Maki


The most common term for a generic high-grade sarcoma has evolved over the years from fibrosarcoma to malignant fibrous histiocytoma (MFH) and now to high-grade undifferentiated pleomorphic sarcoma (UPS). The new nomenclature is utilized to differentiate this tumor from tumors that are truly histiocytic, i.e., histiocytic sarcoma, recognizing that the microscopic morphology of such tumors was not specific for sarcomas. Specific varieties of what was called MFH in the past have proved to be unique entities. For example, myxofibrosarcoma is now a clearly defined sarcoma subtype that was formerly termed myxoid MFH. Myxofibrosarcoma occurs more frequently in the subcutaneous tissue and has infiltrating pattern (Fig. 7.1). Angiomatoid MFH is reclassified as angiomatoid fibrous histiocytoma, having mostly a benign clinical course and occurring in children and young adults. The situation is further complicated since the term MFH is still employed in the bone (and treated most commonly as osteogenic sarcoma in children).


Malignant Fibrous Histiocytoma Fibrous Histiocytoma Inflammatory Myofibroblastic Tumor Histiocytic Sarcoma Embryonal Rhabdomyosarcoma 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Murray F. Brennan
    • 1
  • Cristina R. Antonescu
    • 2
  • Robert G. Maki
    • 3
  1. 1.International Center & Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Department of PathologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Departments of Medicine Pediatrics, and OrthopaedicsMount Sinai School of MedicineNew YorkUSA

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