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Early Life Hypoxic or Hypoxic/Hypercapnic Stress Alters Acute Ventilatory Sensitivity in Adult Mice

  • Kui Xu
  • Solomon Raju Bhupanapadu Sunkesula
  • Pengjing Huang
  • Constantinos P. Tsipis
  • Thomas Radford
  • Gerald Babcock
  • Walter F. Boron
  • Joseph C. LaManna
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 765)

Abstract

In this study we investigated the effect of early life conditioning (hypoxia ± hypercapnia) on adult acute ventilatory sensitivity to hypoxia and hypercapnia. Mice were exposed to either hypoxia (5% O2) or hypoxia/hypercapnia (5% O2/8% CO2) in a normobaric chamber for 2 h at postnatal day 2 (P2), and then returned to normoxia. At 3 months of age, hypoxic ventilatory response (HVR) and hypercapnic ventilatory response (HCVR) were measured using a plethysmograph system. Results showed that HVR was significantly decreased in the P2-hypoxia mice but not in the P2 hypoxia/hypercapnia mice as compared to the P2-normoxic mice, respectively. However, HCVR was significantly decreased in the P2 hypoxia–hypercapnia group but not in the P2-hypoxia group. These data suggest early postnatal hypoxic stress vs. hypoxic/hypercapnic stress plays different roles in fetal programming of the respiratory control system as shown by altered adult acute ventilatory sensitivity.

Keywords

Hypoxia Hypercapnia Ventilatory response Respiratory control 

Notes

Acknowledgments

This study was supported by NIH grant NS 38632.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Kui Xu
    • 1
  • Solomon Raju Bhupanapadu Sunkesula
    • 2
  • Pengjing Huang
    • 2
  • Constantinos P. Tsipis
    • 2
  • Thomas Radford
    • 2
  • Gerald Babcock
    • 2
  • Walter F. Boron
    • 2
  • Joseph C. LaManna
    • 2
  1. 1.Departments of Neurology, School of MedicineCase Western Reserve UniversityClevelandUSA
  2. 2.Departments of Physiology and Biophysics, School of MedicineCase Western Reserve UniversityClevelandUSA

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