Multi-frequency Forced Oscillation Technique Using Impulse Oscillations: Can It Give Mechanical Information about the Lung Periphery?

  • Hiroshi Hamakawa
  • Hiroaki Sakai
  • Ayuko Takahashi
  • Toru Bando
  • Hiroshi Date
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 765)

Abstract

Forced oscillation techniques (FOTs) using sine curved oscillatory waves are used for assessing the lung periphery, but measure only overall respiratory mechanics. Therefore, mathematical models of the respiratory system serve as vehicles to obtain detailed mechanics. Although the simplest model of respiratory mechanics is a simple 3-element series (RIC) model, the constant phase (CP) model is recently used for characterizing respiratory mechanics, which has the advantage of partitioning of respiratory mechanics into airway and tissue components. Meanwhile, FOTs using non-sine curved oscillatory waves are easily applied in patients with severe respiratory diseases because they do not require voluntary apnea. If the latter type of FOTs is as informative as the former, the question arises whether a FOT using non-sine curved oscillatory waves (IOS) could be used to study mechanical properties of the lung periphery. And the CP model should fit the impedance spectra. To answer this, subjects with lymphangioleiomyomatosis (LAM) were recruited as a cohort of patients with lung parenchymal disease. Impedance spectra obtained by the IOS were fitted to the CP and RIC models. Mean values of goodness of fit from the CP and RIC models were 0.978 ± 0.022 and 0.968 ± 0.026, respectively. The extra sum-of-squares F test was used to compare the two mathematical models. The F ratio was 2.37 ± 1.40 and the p-value was 0.29 ± 0.21. Unfortunately, there was no compelling evidence for adopting the CP model for the evaluation of impedance spectra obtained by IOS. This result might relate to the uncertainty of IOS for detecting mechanical properties of the lung periphery.

Keywords

Lung periphery Multifrequency forced oscillation 

Notes

Acknowledgment

This work was supported by Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science (20591667).

References

  1. 1.
    Oostveen E, MacLeod D, Lorino H et al (2003) The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J 22(6):1026–1041CrossRefPubMedGoogle Scholar
  2. 2.
    Hantos Z, Daroczy B, Suki B, Nagy S, Fredberg JJ (1992) Input impedance and peripheral inhomogeneity of dog lungs. J Appl Physiol 72:168–178CrossRefPubMedGoogle Scholar
  3. 3.
    Frei J, Jutla J, Kramer G, Hatzakis GE, Ducharme FM, Davis GM (2005) Impulse oscillometry: reference values in children 100 to 150 cm in height and 3 to 10 years of age. Chest 128:1266–1273CrossRefPubMedGoogle Scholar
  4. 4.
    Smith HJ, Reinhold P, Goldman MD (2005) Forced oscillation technique and impulse oscillometry. Eur Respir Mon 31(5):72–105Google Scholar
  5. 5.
    Guo YF, Herrmann F, Michel JP, Janssens JP (2005) Normal values for respiratory resistance using forced oscillation in subjects >65 years old. Eur Respir J 26:602–608CrossRefPubMedGoogle Scholar
  6. 6.
    Olson HF Dynamical analogies, 2nd edn. Van Nostarand Reinhold Co., New York, 278 ppGoogle Scholar
  7. 7.
    Lándsér FJ, Nagles J, Demedts M, Billiet L, van de Woestijne KP (1976) A new method to determine frequency characteristics of the respiratory system. J Appl Physiol 41(1):101–106PubMedGoogle Scholar
  8. 8.
    Wilson AA, Murphy GJ, Hamakawa H et al (2010) Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. J Clin Invest 120(1):379–389CrossRefPubMedGoogle Scholar
  9. 9.
    Taveira-DaSilva AM, Stylianou MP, Hedin CJ et al (2003) Maximal oxygen uptake and severity of disease in lymphangioleiomyomatosis. Am J Respir Crit Care Med 168(12):1427–1431CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Hiroshi Hamakawa
    • 1
  • Hiroaki Sakai
    • 2
  • Ayuko Takahashi
    • 3
  • Toru Bando
    • 2
  • Hiroshi Date
    • 2
  1. 1.Department of Thoracic SurgeryKobe City Medical Center General HospitalKobe CityJapan
  2. 2.Department of Thoracic SurgeryKyoto UniversityKyotoJapan
  3. 3.Department of Biomedical EngineeringBoston UniversityBostonUSA

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