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Nanoparticle-Mediated Photothermal Therapy of Brain Tumors

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Optical Methods and Instrumentation in Brain Imaging and Therapy

Part of the book series: Bioanalysis ((BIOANALYSIS,volume 3))

Abstract

Nanoparticles (10–1,000 nm diameter) have been investigated for use in numerous diagnostic and therapeutic applications. Gold nanoparticles are particularly appealing due to their biological inertness and the ability to conjugate a wide variety of ligands to their surface. Additionally, their optical properties can be tuned through variations of their size, shape, and composition. For example, gold–silica nanoshells, consisting of a spherical dielectric silica core (100–120 nm diameter) surrounded by a 10–20 nm gold shell, have a strong resonant absorption at approximately 800 nm where light has significant penetration in biological tissues. Following light absorption, surface electrons are photoexcited and the resultant heated electron gas is dissipated to the surrounding medium causing thermal damage. The ability of nanoparticles to convert optical energy to thermal energy makes them ideally suited for photothermal therapy (PTT). This review focuses on the utility of gold–silica nanoshells in PTT of brain tumors. PTT has proven effective in a number of in vitro and in vivo studies. Of particular clinical relevance are results demonstrating PTT efficacy in an orthotopic canine model.

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Authors and Affiliations

  1. Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa, IA, 52242, USA

    Amani R. Makkouk

  2. Department of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, NV, 89154-3037, USA

    Steen J. Madsen

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  1. Amani R. Makkouk
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  2. Steen J. Madsen
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Correspondence to Steen J. Madsen .

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  1. , Dept. of Health Physics and, University of Nevada, Las Vegas, S. Maryland Pkwy. 4505, Las Vegas, 89154-3037, USA

    Steen J. Madsen

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Makkouk, A.R., Madsen, S.J. (2013). Nanoparticle-Mediated Photothermal Therapy of Brain Tumors. In: Madsen, S. (eds) Optical Methods and Instrumentation in Brain Imaging and Therapy. Bioanalysis, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4978-2_10

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  • DOI: https://doi.org/10.1007/978-1-4614-4978-2_10

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