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Therapy for the Coronary Circulation

  • Robert J. Tomanek
Chapter

Abstract

The need to maintain or enhance myocardial perfusion is apparent from the many conditions in which coronary vascular reserve is limited or flow is impeded to the extent that ischemia and death can occur. Examples, as described in the preceding chapters of this book, include coronary anomalies, changes associated with aging, coronary artery disease, cardiac hypertrophy, and coronary vascular dysfunction. The classical treatments are pharmacological or mechanical revascularization therapies. Pharmacological approaches are aimed at reducing O2 demand, increasing its utilization, or enhancing myocardial perfusion by improving vascular reactivity. Surgical or percutaneous mechanical interventions are used to correct coronary anomalies, open occluded channels, or provide vascular bypass for severely occluded arteries. More recently gene and cell therapy have been proposed as ways of increasing vascular capacity to prevent ischemic events. These approaches have great potential. The goal of this chapter is to summarize the effects of pharmacological, gene, protein, and stem cell therapies on myocardial perfusion.

Keywords

Vascular Endothelial Growth Factor Myocardial Perfusion Infarct Size Capillary Density Intramyocardial Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

EC

Endothelial cell

EPC

Endothelial progenitor cell

FGF

Fibroblast growth factor

G-CSF

Granulocyte-colony stimulating factor

HIF

Hypoxia inducible factor

MCP-1

Monocyte chemoattractant-1

MSC

Mesenchymal stem cell

SDF-1

Stromal-derived factor

VEGF

Vascular endothelial growth factor

VSMC

Vascular smooth muscle cell

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Robert J. Tomanek
    • 1
  1. 1.Carver College of Medicine Cardiovascular CenterUniversity of IowaIowa CityUSA

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