Jatropha Pharmacognosy, Phytochemistry and Pharmacology: A Review

Chapter

Abstract

Jatropha curcas L. (physic nut) belongs to Euphorbiaceae and is gaining importance for the production of biodiesel. It is considered as a potential source of non-edible fuel producing plant along with its different medicinal properties and grows well in the tropical and subtropical climate in India. A detailed pharmacognosy of the vegetative parts of the J. curcas including other Jatropha species has been reviewed. Phytochemicals, biological activities, macroscopical and microscopical characters, chemistry and various medicinal uses have been reviewed.

Keywords

Starch Income Diesel Flavonoid Thiol 

References

  1. Adolf W, Opferkuch HJ, Hecker E (1984) Irritant phorbol derivatives from four Jatropha species. Phytochemistry 23:129–132CrossRefGoogle Scholar
  2. Akintayo ET (2004) Characteristics and composition of Parkia biglobbossa and Jatropha curcas oils and cakes. Bioresour Technol 92:307–310PubMedCrossRefGoogle Scholar
  3. Auvin C, Carine Baraguey C, Blond A, Lezenven F, Pousset JL, Bodo B (1997) Curcacycline B, a cyclic nonapeptide from Jatropha curcas enhancing rotamase activity of cyclophilin. Tetrahedron Lett 38:2845–2848CrossRefGoogle Scholar
  4. Bahadur B, Reddy SM, Govardhan S, Giridhar P (1997) Anitimicrobial activity in eight species of Jatropha L. (Euphorbiaceae). J Indian Bot Soc 77:190–191Google Scholar
  5. Balaji R, Suba V, Rekha N, Deecaraman M (2009) Hepatoprotective activity of methanolic fraction of Jatropha curcas on aflatoxin B1 induced hepatic carcinoma. Int J Phys Sci 1:287–296Google Scholar
  6. Ballantine JA (1969) The isolation of two esters of the naphthaquinone alcohol, shikonin, from the shrub Jatropha glandulifera. Phytochemistry 8:158–159CrossRefGoogle Scholar
  7. Banerji J, Das B, Chatterjee A, Shooler JN (1984) Gadain, A lignan from Jatropha gossypiifolia. Phytochemistry 23:2323–2327CrossRefGoogle Scholar
  8. Baraguey C, Blond A, Correia I, Pousset JL, Bodo B, Auvin-Guette C (2000) Mahafacyclina A, cyclic heptapeptide from Jatropha mahafalensis exhibiting β-bulge conformation. Tetrahedron Lett 41:325–329CrossRefGoogle Scholar
  9. Beatrice M, Neuville L, Moreau NJ et al (2005) Multidrug resistance reversal agent from Jatropha elliptica. Phytochemistry 66:1804–1811CrossRefGoogle Scholar
  10. Benavides A, Montoro P, Bassarello C, Piacente S, Pizza C (2006) Catechin derivatives in Jatropha macrantha stems: characterisation and LC/ESI/MS/MS quali-quantitative analysis. J Pharm Biomed Anal 40:639–647PubMedCrossRefGoogle Scholar
  11. Biswanath D, Anjani G (1999) Gossypidien a lignan from stems of Jatropha gossypiifolia. Phytochemistry 51:115–117CrossRefGoogle Scholar
  12. Biswanath D, Kashinatham A, Venkataiah B, Srinivas KVNS, Mahender G, Ravinder Reddy M (2003) Cleomiscosin A, a coumarino-lignoid from Jatropha gossypiifolia. Biochem Syst Ecol 31:1189–1191CrossRefGoogle Scholar
  13. Biswanath D, Padma Rao S, Srinivas KVNS, Ratna D (1996) Jatrodien a lignan from the stems of Jatropha gossypiifolia. Phytochemistry 41:985–987CrossRefGoogle Scholar
  14. Biswanath D, Ravinder Reddy K, Ravikanth B, Venugopal Raju T, Sridhar B, Usman Khan P et al (2009) Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida. Bioorg Med Chem Lett 19:77–79CrossRefGoogle Scholar
  15. Biswanath D, Ratna D (1995) Gossypifan a lignan from Jatropha gossypiifolia. Phytochemistry 40:931–932CrossRefGoogle Scholar
  16. Biswanath D, Satya Kumar A, Kumar JN, Venugopal Raju T (2010) A new macrocyclic diterpenoid from Jatropha multifida. Nat Prod Res 24:1510–1513CrossRefGoogle Scholar
  17. Biswanath D, Venkataiah B (1999) A rare diterpene from Jatropha gossypiifolia. Biochem Syst Ecol 27:759–760CrossRefGoogle Scholar
  18. Biswanath D, Venkataiah B (2001) A minor coumarino-lignoid from Jatropha gossypiifolia. Biochem Syst Ecol 29:213–214CrossRefGoogle Scholar
  19. Brittaine R, Lutaladio N (2010) Jatropha: A small holder bioenergy crop. Integr Crop Manag 8:45–60Google Scholar
  20. Brum RL, Honda NK, Mazarin SM, Hess SC, Cavalheiro AJ, Monache FD (1998) Jatrowedione, a lathyrane diterpene from Jatropha weddelliana. Phytochemistry 48:1225–1227CrossRefGoogle Scholar
  21. Chatterjee A, Biswanath D, Pascard C, Prange T (1981) Crystal structure of a lignan from Jatropha gossypiifolia. Phytochemistry 20:2047–2048CrossRefGoogle Scholar
  22. Chaturvedi P (2008) The isolation, characterisation and antimicrobial activity of alkaloids of Jatropha curcas and Piper longum. J Phytol Res 1:53–56Google Scholar
  23. Chen WH, Chen CH, Chang CMJ, Chiu YH, Hsiang D (2009) Supercritical carbon dioxide extraction of triglycerides from Jatropha curcas L. seeds. J Supercrit Fluids 51:174–180CrossRefGoogle Scholar
  24. Chopra RN, Nayar SL, Chopra IC (1986) Glossary of Indian medical plants. CSIR, New Delhi, p 145Google Scholar
  25. Das B, Banerji J (1988) Arylnaphthalene lignan from Jatropha gossypiifolia. Phytochemistry 27:3684–3686CrossRefGoogle Scholar
  26. Dehgan B, Webster GL (1978) Three new species of Jatropha (Euphorbiaceae) from Western Mexico. Madrono 25:30–39Google Scholar
  27. Dominguez XA, Cano G, Franco R, Villarreal AM, Watson WH, Zarel V (1980) Riolozatrione, a new class of diterpene from Jatropha dioica var. sessiliflora. Phytochemistry 19:2478CrossRefGoogle Scholar
  28. Duke JA (1988) CRC handbook of medicinal herbs. CRC Press, Boca Raton, pp 253–254Google Scholar
  29. Foidl N, Foidl G, Sanchez M, Mittelbach M, Hackel S (1996) Jatropha curcas L. as a source for the production of biofuel in Nicaragua. Bioresour Technol 58:77–82CrossRefGoogle Scholar
  30. Fojas FR, Garcia LL, Venzon EL, Sison FM, Villanueva BA, Fojas AJ et al (1986) Pharmacological studies on J. curcas as a possible source of anti-arrhythmic (β-blocker) agent. The Philipp J Sci 115:317–328Google Scholar
  31. Gandhi VM, Cherian KM, Mulky MJ (1995) Toxicological studies on ratanjyot oil. Food Chem Toxicol 33:39–42PubMedCrossRefGoogle Scholar
  32. Goonasekera MM, Gunawardana VK, Jayasena K, Mohammed SG, Balasubramaniam S (1995) Pregnancy terminating effect of Jatropha curcas in rats. J Ethnopharmacol 47:117–123PubMedCrossRefGoogle Scholar
  33. Guette CA, Baraguey C, Blond A, Xavier HS, Pousset JL, Bodo B (1999) Pohlianins A, B and C, Cyclic peptides from the latex of Jatropha pohliana ssp. Molissima. Tetrahedron 55:11495–11510CrossRefGoogle Scholar
  34. Gupta RC (1985) Pharmacognostic studies on ‘Dravanti’ part-I Jatropha curcas Linn. Proc Ind Acad Sci Plant Sci 94:65–82Google Scholar
  35. Heller J (1996) Physic nut. Jatropha curcas L. Promoting the conservation and use of underutilised and neglected crops. Institute of Plant Genetics and Crop Plant Research, Gatersleben/International Plant Genetic Resources Institute, Rome, p 54Google Scholar
  36. Hemalatha A, Radhakrishnaiah M (1993) Chemosystematics of Jatropha. J Econ Taxon Bot 17:75–77Google Scholar
  37. Hufford CD, Oguntimein BO (1987) Non-polar constituents of Jatropha curcas. Lloydia 41:161–165Google Scholar
  38. Idu M, Timothy O, Onyibe HI, Comor AO (2009) Comparative morphological and anatomical studies on the leaf and stem of some medicinal plants: Jatropha curcas L. and Jatropha tanjorensis J.L. Ellis and Saroja (Euphorbiaceae). Ethnobot Leafl 13:1232–1239Google Scholar
  39. Jakupovic J, Grenz M, Schmeda-hirschmann G (1988) Rhamnofolane derivatives from Jatropha grossidentata. Phytochemistry 27:2997–2998CrossRefGoogle Scholar
  40. Katwal RPS, Soni PL (2003) Biofuels: an opportunity for socioeconomic development and cleaner environment. Indian Forester 129:939–949Google Scholar
  41. Kaushik N, Kumar S (2004) Jatropha curcas L. Silviculture and uses. Agrobios (India), JodhpurGoogle Scholar
  42. Khafagy SM, Mohamed YA, Abdel NA, Mahmoud ZF (1977) Phytochemical study of Jatropha curcas. Plant Med 31:274–277CrossRefGoogle Scholar
  43. Kosasi S, Van der sluis WG, Labadie RP (1989a) Multifidol and multifidol glucoside from the latex of Jatropha multifida. Phytochemistry 28:2439–2441CrossRefGoogle Scholar
  44. Kosasi S, Van der sluis WG, Boelens R, Hart LA, Labadie RP (1989b) Labaditin, a novel cyclic decapeptide from the latex of Jatropha multifida L. (Euphorbiaceae).Isolation and sequence determination by means of two-dimensional NMR. FEBS Lett 256:91–96CrossRefGoogle Scholar
  45. Kumar A, Sharma S (2008) An evaluation of multipurpose oil seed crop for industrial uses (Jatropha curcas L.): A review. Ind crop prod 28:1–10CrossRefGoogle Scholar
  46. Liberalino AA, Bambirra EA, Moraes-Santos T, Vieira EC (1988) Jatropha curcas L. seeds: chemical analysis and toxicity. Arq Biol Technol 31:539–550Google Scholar
  47. Makkar HPS, Becker K, Sporer F, Wink M (1997) Studies on nutritive potential and toxic constituents of different provenances of Jatropha curcas. J Agric Food Chem 45:3152–3157CrossRefGoogle Scholar
  48. Martini LH, Souza CR, Marques PB, Calixto JB, Yunes RA, Souza DO (2000) Compounds extracted from Phyllanthus and Jatropha elliptica inhibit the binding of [3 H] Glutamate and [3 H] GMP-PNP in rat cerebral cortex membrane. Neurochem Res 25:211–215PubMedCrossRefGoogle Scholar
  49. Mitra CR, Bhatnagar SC, Sinha MK (1970) Chemical examination of Jatropha curcas. Ind J Chem 8:1047Google Scholar
  50. Muanza DN, Euler KL, Williams L, Newman DJ (1995) Screening for antitumor and anti-HIV activities of nine medicinal plants from Zaire. Intl J Pharmacog 33:98–106CrossRefGoogle Scholar
  51. Mujumdar AM, Misar AV (2004) Anti–inflammatory activity of Jatropha curcas roots in mice and rats. J Ethnopharmacol 90:11–15PubMedCrossRefGoogle Scholar
  52. Naengchomnong W, Thebtaranonth Y, Wiriyachitra P, Okamoto KT, Clardy J (1986) Isolation and structure determination of four novel diterpenes of Jatropha curcas. Tetrahedron Lett 27:2439–2442CrossRefGoogle Scholar
  53. Naengchomnong W, Tarnchompoo B, Thebtaranonth Y (1994) (+)-Jatropha, (+)-marmesin, propacin and jatrophin from the roots of Jatropha curcas (Euphorbiaceae). J Sci Soc Thai 20:73–83CrossRefGoogle Scholar
  54. Nath LK, Dutta SK (1991) Extraction and purification of curcain, a protease from the latex of Jatropha curcas L. J Pharm Pharmacol 43:111–114PubMedCrossRefGoogle Scholar
  55. Nath LK, Dutta SK (1997) Acute toxicity studies and wound healing response of curcain, a proteolytic enzyme extract from the latex of Jatropha curcas L. In: Gubitz GM, Mittelbach M, Trabi M (eds) Biofuels and industrial products from Jatropha curcas. DBV Graz, Graz, pp 82–86Google Scholar
  56. Nayak BS, Patel KN (2010) Pharmacognostic studies of the Jatropha curcas leaves. Intl J PharmTech Res 2:140–143Google Scholar
  57. Nwosu MO, Okafor JL (1995) Preliminary studies of the antifungal activities of some medicinal plants against Basidiobolus and some other pathogenic fungi. Mycoses 38:191–195PubMedCrossRefGoogle Scholar
  58. Olapeju OA, Kayode A, Olusegun E, James BG (2007) Antibacterial diterpenoids from Jatropha podagrica Hook. Phytochemistry 68:2420–2425CrossRefGoogle Scholar
  59. Openshaw K (2000) A review of Jatropha curcas: an oil plant of unfulfilled promise. Biomass Bioenergy 19:1–15CrossRefGoogle Scholar
  60. Parthasarathy MR, Pardha Saradhi K (1984) A coumarino-lignan from Jatropha glandulifera. Phytochemistry 23:861–869CrossRefGoogle Scholar
  61. Pertino M, Schmeda-Hirschmann G, Rodrfguez JA, Theoduloz C (2007) Gastroprotective effect and cytotoxicity of terpenes from the Paraguayan crude drug “yagua rova” (Jatropha isabelli). J Ethnopharmacol 111:553–559PubMedCrossRefGoogle Scholar
  62. Rata Krishnan P, Paramathma M (2009) Potentials and Jatropha species wealth of India. Curr Sci 97:1000–1004Google Scholar
  63. Ravindranath N, Ramesh C, Biswanath D (2003) A rare dinorditerpene from Jatropha curcas. Biochem Syst Ecol 31:431–432CrossRefGoogle Scholar
  64. Ravindranath N, Ravinder Reddy M, Mahender G, Ramu R, Ravi Kumar K, Biswanath D (2004) Deoxypreussomerins from Jatropha curcas: are they also plant metabolites? Phytochemistry 65:2387–2390CrossRefGoogle Scholar
  65. Rivera-Lorca JA, Ku-Vera JC (1997) Chemical composition of three different varieties of J. curcas from Mexico. In: Gubitz GM, Mittelbach M, Trabi M (eds) Biofuels and industrial products from Jatropha curcas. DBV Graz, Graz, pp 47–52Google Scholar
  66. Sankara Subramanian S, Nagarajan S, Sulochana N (1971) Flavonoids of the leaves of Jatropha gossypiifolia. Phytochemistry 10:1690CrossRefGoogle Scholar
  67. Santos AF, Santana AE (1999) Molluscicidal activity of the diterpenoids jatrophone and jatropholones A and B isolated from Jatropha elliptica (Pohl) Muell. Arg Phytother Res 13:660–664CrossRefGoogle Scholar
  68. Shanti BM, Mukherjee A, Vijayakumar M (2010) Pharmacognostical and phytochemical evaluation of leaves extract of Jatropha curcas Linn. Pharmacog J 2:9–14Google Scholar
  69. Sharma GD, Gupta SN, Khabiruddin M (1997) Cultivation of Jatropha curcas as a future source of hydrocarbon and other industrial products. In: Gubitz GM, Mittelbach M, Trabi M (eds) Biofuels and industrial products from Jatropha curcas. DBV Graz, Graz, pp 19–21Google Scholar
  70. Solsoloy AD, Solsoloy TS (1997) Pesticidal efficacy of formulated J. curcas oil on pests of selected field crops. In: Gubitz GM, Mittelbach M, Trabi M (eds) Biofuels and industrial products from Jatropha curcas. DBV Graz, Graz, pp 216–226Google Scholar
  71. Somashekar S, Saraswati LU, Alaya LU, Venkata RV (2006) Wound healing activities of bark extract of Jatropha curcas Linn in albino rats. Saudi Med J 27:1473–1476Google Scholar
  72. Staubmann R, Schubert-Zsilavecz M, Hiermann A, Kartnig T (1999a) A complex of 5-hydroxypyrrolidin-2-one and pyrimidine-2, 4-dione isolated from Jatropha curcas. Phytochemistry 50:337–338CrossRefGoogle Scholar
  73. Staubmann R, Ncube I, Gubitz GM, Steiner W, Read JS (1999b) Esterase and lipase activity in Jatropha curcas L. seeds. J Biotechnol 75:117–126PubMedCrossRefGoogle Scholar
  74. Stirpe F, Pession A, Brizzi A, Lorenzoni E, Strochi P, Montanaro L et al (1976) Studies on the proteins from the seeds of Croton tigilium and Jatropha curcas. Biochem J 156:1–6PubMedGoogle Scholar
  75. Sutthivaiyakit S, Mongkolvisut W, Ponsitipiboon P, Prabpai S, Kongsaeree P, Ruchirawatb S et al (2003) A novel 8, 9-seco-rhamnofolane and a new rhamnofolane endoperoxide from Jatropha integerrima roots. Tetrahedron Lett 44:3637–3640CrossRefGoogle Scholar
  76. Taylor MD, Smith AB, Furst GT, Gunasekara SP, Bevelle CA, Cordell GA et al (1983) Plant anticancer agents 28. New antileukemic jatrophone derivatives from Jatropha gossypiifolia: structural and stereochemical assignment through nuclear magnetic resonance spectroscopy. J Am Chem Soc 105:3177–3183CrossRefGoogle Scholar
  77. Tewari JP, Shukla IK (1982) Inhibition of infectivity of two strains of watermelon mosaic virus by latex of some angiosperms. Geobios 9:124–126Google Scholar
  78. Thomas R, Sah NK, Sharma PB (2008) Therapeutic biology of Jatropha curcas: a mini review. Curr Pharm Biotechnol 9:315–324PubMedCrossRefGoogle Scholar
  79. Van den berg AJJ, Horsten SF, van den Kettenes BJJ, Kroes BH, Beukelman CJ, Loeflang B et al (1995a) Curcacycline A: a novel cyclic octapeptide isolated from the latex of Jatropha curcas Linn. FEBS Lett 358:215–218PubMedCrossRefGoogle Scholar
  80. Van den berg AJJ, Horsten SFAJ, Kettenes-Van Den Bosch JJ, Kroes BH, Labadie RP (1995b) Multifidin a cyanoglucoside in the latex of Jatropha multifida. Phytochemistry 40:597–598CrossRefGoogle Scholar
  81. Van den Berg AJJ, Horsten SFAJ, Bosch JJK, Beukelman CJ, Kroes BH, Leeflang BR et al (1996) Podacycline A and B, two cyclic peptides in the latex of Jatropha podagrica. Phytochemistry 42:129–133PubMedCrossRefGoogle Scholar
  82. Verma KC, Gaur AK (2009) Jatropha curcas L.: substitute for conventional energy. World J Agric Sci 5:552–556Google Scholar
  83. Villegas LF, Fernandez ID, Maldonado H, Torres R, Zavaleta A, Vaisberg AJ, Hammond GB (1997) Evaluation of the wound-healing activity of selected traditional medicinal plants from Peru. J Ethnopharmacol 55:193–200PubMedCrossRefGoogle Scholar
  84. Viswanathan MB, Ramesh N, Ahilan A, Lakshmanaperumalsamy P (2004) Phytoconstituents and antimicrobial activity from the stems of Jatropha maheshwarii. Med Chem Res 13:361–368CrossRefGoogle Scholar
  85. Wink M, Koschmieder C, Sauerwein M, Sporer F (1997) Phorbol esters of J. curcas—biological activities and potential applications. In: Gubitz GM, Mittelbach M, Trabi M (eds) Biofuels and industrial products from Jatropha curcas. DBV Graz, Graz, pp 160–166Google Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.University College of Pharmaceutical Sciences, Kakatiya UniversityWarangalIndia

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