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Neural-Immune Interactions in Brain Function and Alcohol Related Disorders pp 279–306Cite as

Role of Toll-Like Receptor 4 in Alcohol-Induced Neuroinflammation and Behavioral Dysfunctions

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Abstract

Until quite recently, the central nervous system (CNS) has been considered an autonomous unit nourished by blood and shielded not only from circulating immune cells but also from pathogens and toxins originating from circulation. However, it is now well established that immune surveillance occurs in the normal CNS and that inflammatory responses can take place in the neural plasticity and disease context. The CNS presents a well-organized series of innate immune reactions in response to systematic bacterial and viral infections and to cerebral injury [1, 2]. Activation of the innate immune system is an important component of inflammatory response.

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Acknowledgments

We thank M. March for excellent professional assistance in preparing the figures in this manuscript. The authors’ experimental work has been supported by grants from the Spanish Ministry of Science and Innovation (SAF 2009-07503), the Spanish Ministry of Health, the Carlos III Institute (RTA Network, RD06/0001/1119), PNSD (2010I037), PROMETEO/2009/072, and General Direct Drug Dependence, GV.

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  1. Department of Cell Pathology, Príncipe Felipe Research Center, Avda. Autopista del Saler 16-3 (junto Oceanográfico), 46012, Valencia, Spain

    Consuelo Guerri & María Pascual

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  1. Consuelo Guerri
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  2. María Pascual
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Correspondence to Consuelo Guerri .

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  1. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Fishers Lane 5635, Bethesda, 20892, Maryland, USA

    Changhai Cui

  2. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Fishers Lane 5635, Bethesda, 20892, Maryland, USA

    Lindsey Grandison

  3. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Fishers Lane 5635, Bethesda, 20892, Maryland, USA

    Antonio Noronha

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Guerri, C., Pascual, M. (2013). Role of Toll-Like Receptor 4 in Alcohol-Induced Neuroinflammation and Behavioral Dysfunctions. In: Cui, C., Grandison, L., Noronha, A. (eds) Neural-Immune Interactions in Brain Function and Alcohol Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4729-0_9

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