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Neuroimmune Genes and Alcohol Drinking Behavior

  • R. Adron Harris
  • Yuri A. Blednov
Chapter

Abstract

Alcoholism (alcohol dependence) is one of the most expensive (more than $185 billion/year for the USA) and damaging chronic diseases. Treatment options are limited (there are only three FDA-approved drugs for alcohol dependence), and there is a high rate of relapse for all treatments. Emerging results suggest that the cytokine responses to alcohol (perhaps via endotoxins) promote persistent and excessive alcohol consumption, which may in turn promote further inflammatory responses, producing a positive feedback loop which that spirals out of control. Although there is considerable effort to develop pharmacotherapies to reduce alcohol consumption, craving, and relapse, most are directed at “traditional” targets involved in synaptic transmission. Neuroinflammatory pathways in brain (and other organs) may be unexplored targets for medication development to reduce excessive alcohol consumption and prevent relapse.

Keywords

Alcohol Consumption Alcohol Dependence Recombinant Inbred Excessive Alcohol Consumption Reduce Alcohol Consumption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This research was supported by grants from the National Institute of Alcohol Abuse and Alcoholism to the INIA West Consortium (AA13520, AA06399).

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Waggoner Center for Alcohol and Addiction ResearchUniversity of Texas at AustinAustinUSA

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