Diarrhea Among Children in Developing Countries
Diarrhea continues to stand among the most important causes of global morbidity and mortality in children under 5 years of age. Although the introduction of oral rehydration and other case-management strategies have reduced acute diarrhea fatalities, many of the survivors develop persistent diarrhea and/or deficiencies of growth and cognition. Thus understanding the true global burden of diarrhea requires attention to acute diarrhea as well is its sequelae. To understand the etiology of moderate to severe diarrhea among children in high mortality areas of sub-Saharan Africa and south Asia we performed a comprehensive case-control study of children under 5 years of age at seven sites. Each site employed an identical case-control study design and each utilized a uniform comprehensive set of microbiological assays to identify the likely bacterial, viral and protozoal etiologies. Results of the studies will inform diarrhea prevention and management efforts worldwide.
KeywordsEnteric Pathogen Acute Diarrhea Enteric Infection Oral Rehydration Salt Oral Rehydration Therapy
- 3.Von PM (1873) What We can Do against Cholera: Practical Instructions concerning what to Do to Prevent an Epidemic as Well as How to Guard against it during its Prevalence. Public Health Pap Rep 1:317–335Google Scholar
- 10.Donnenberg MS (1995) Enteropathogenic Escherichia coli. In: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL (eds) Infections of the Gastrointestinal Tract. Raven, New York, p 709–726Google Scholar
- 12.Royan SV, Jones RM, Koutsouris A, Roxas JL, Falzari K, Weflen AW et al (2010) Enteropathogenic E. coli non-LEE encoded effectors NleH1 and NleH2 attenuate NF-kappaB activation. Mol Microbiol 78(5):1232–1245Google Scholar
- 16.Guerrant R, Schorling J, McAuliffe J, Souza Md (1992) Diarrhea as a cause and effect of malnutrition: Diarrhea prevents catch-up growth and malnutrition increases diarrhea frequency and duration. AJTMH 47(Suppl 1):28–35Google Scholar
- 19.Pitzer VE, Patel MM, Lopman BA, Viboud C, Parashar UD, Grenfell BT (2011) Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions. Proc Natl Acad Sci USAGoogle Scholar