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Biology and Regulation of Blood-Tissue Barriers pp 281–294Cite as

Transcriptional Regulation of Cell Adhesion at the Blood-Testis Barrier and Spermatogenesis in the Testis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 763))

Abstract

Spermatogenesis involves precise co-ordination of multiple cellular events that take place in the seminiferous epithelium composed of Sertoli cells and developing germ cells during the seminiferous epithelial cycle. Given the cyclic and co-ordinated nature of spermatogenesis, temporal and spatial expression of certain genes pertinent to a specific cellular event are essential. As such, transcriptional regulation is one of the major regulatory machineries in controlling the cell type- and stage-specific gene expression, some of which are under the influence of gonadotropins (e.g., FSH and LH) and sex steroids (e.g., testosterone and estradiol-17β). Recent findings regarding transcriptional control of spermatogenesis, most notably target genes at the Sertoli-Sertoli and Sertoli-spermatid interface at the site of the blood-testis barrier (BTB) and apical ectoplasmic specialization (apical ES), respectively, involving in cell adhesion are reviewed and discussed herein. This is a much neglected area of research and a concerted effort by investigators is needed to understand transcriptional regulation of cell adhesion function in the testis particularly at the BTB during spermatogenesis.

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Authors and Affiliations

  1. School of Biological Sciences, The University of Hong Kong, Pokfulam, China

    Wing-Yee Lui

  2. Center for Biomedical Research, New York, New York, USA

    C. Yan Cheng

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  1. Wing-Yee Lui
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  1. Center for Biomedical Research, Population Council, New York, New York, USA

    C. Yan Cheng PhD

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Lui, WY., Cheng, C.Y. (2013). Transcriptional Regulation of Cell Adhesion at the Blood-Testis Barrier and Spermatogenesis in the Testis. In: Cheng, C.Y. (eds) Biology and Regulation of Blood-Tissue Barriers. Advances in Experimental Medicine and Biology, vol 763. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4711-5_14

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