• Dennis P. O’Malley
Part of the Atlas of Anatomic Pathology book series (AAP)


In this chapter, the broad range of infections and their histologic effects in the spleen are illustrated. A broad variety of infections occur in the spleen representative of bacterial, mycobacterial, fungal, viral, and protozoal/parasitic infections. The variety of bacterial and mycobacterial effects illustrated in the spleen includes generalized bacterial abscess and infections of the family of mycobacteria including tuberculosis, leprosy, and Mycobacterium avium-intracellulare. The relatively common features of infectious mononucleosis, due to Epstein-Barr virus (EBV), are illustrated. Other viruses, including Cytomegalovirus, Herpes simplex virus, and HIV, are illustrated. A variety of fungal and protozoal infections, most often seen in immunocompromised patients, are illustrated, including Pneumocystis and Cryptococcus. Other fungal infections are also illustrated. Finally, protozoal infections common in the underdeveloped world, malaria and leishmaniasis, are illustrated.


Infection abscess tuberculosis Mycobacterium avium-intracellulare acid fast bacillus leprosy EBV Epstein-Barr virus infectious mononucleosis plasma cell Castleman disease HHV-8 Cytomegalovirus CMV herpes HIV Cryptococcus histoplasmosis coccidioidomycosis fungus fungal infection malaria Leishmaniasis toxoplasmosis 


  1. 1.
    O’Malley DP, George TI, Orazi A, Abbondanzo S. Armed Forces Institute of Pathology: Benign and reactive conditions of lymph node and spleen [book]. Silver Spring, MD: American Registry of Pathology Press; 2009.Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Dennis P. O’Malley
    • 1
    • 2
  1. 1.Clarient Inc./GE HealthcareAliso ViejoUSA
  2. 2.Department of HematopathologyM.D. Anderson Cancer Center/University of TexasHoustonUSA

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