Abstract
Ischemic heart disease is the major cause of death in the United States (1). Majority opinion holds that the underlying cause is obstruction of the coronary artery lumen by an atherosclerotic lesion with or without a superimposed thrombus (2). In coronary arteries, atherosclerotic lesions predominate at the bifurcation of the main stem of the left coronary artery and in the anterior descending branch just beyond (3,4). Stenosis by atherosclerotic plaques (5) and occlusion by plaques or thrombi (6–8) occur most frequently in the same areas.
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References
National Center for Health Statistics. 1969. Vital statistics of the United States, 1967: Volume II — Mortality, Part A. US Department of Health, Education and Welfare, Public Health Service. US Government Printing Office, Washington, D.C.
Strong, J.P., L.A. Solberg, and C. Restrepo. 1968. Atherosclerosis in persons with coronary heart disease. Lab. Invest. 18: 527–537.
Wolkoff, K. 1929. Ueber die Atherosklerose der Coronararterien des Herzens. Beitr. Path. Anat. 82: 555–596.
Montenegro, M.R., and D.A. Eggen. 1968. Topography of atherosclerosis in the coronary arteries. Lab. Invest. 18: 586–593.
Berger, R.L., and H.C. Stary. 1971. Anatomic assessment of operability by the saphenous vein bypass operation in coronary artery disease. New Engl. J. Med. 285: 248–252.
Schlesinger, M.J., and P.M. Zoll. 1941. Incidence and localization of coronary artery occlusions. Arch. Path. 32: 178–188.
Pitt, B., P.M. Zoll, H.L. Blumgart, and D.G. Freiman. 1963. Location of coronary arterial occlusions and their relation to the arterial pattern. Circulation 28: 35–41.
Rodriguez, F.L., S.L. Robbins, and M. Banasiewicz. 1964. Postmortem angiographic studies on the coronary arterial circulation. Incidence and topography of occlusive coronary lesions; relation to anatomic pattern of large coronary arteries. Amer. Heart J. 68: 490–499.
Strong, J.P., D.E. Eggen, and H.C. Stary. 1976. Reversibility of fatty streaks in rhesus monkeys. Primates in Medicine, vol. 9, pp. 300–320, Karger, Basel.
Anitschkow, N.N. 1928. Ueber die Rueckbildungsvorgaenge bei der experimentellen Atherosklerose. Verh. dtsch. Path. Ges. 23: 473–478. Zentralbl. Allg. Path. path. Anat., Suppl. to vol. 43.
Anitschkow, N.N. 1967. A history of experimentation on arterial atherosclerosis in animals. In: Cowdry’s Arteriosclerosis: A Survey of the Problem. Ed. by H.T. Blumenthal, Charles C. Thomas, Springfield, p. 32.
Armstrong, M.L., E.D. Warner, and W.E. Connor. 1970. Regression of coronary atheromatosis in rhesus monkeys. Circ. Res. 27:59–67.
Vesselinovitch, D., R.W. Wissler, K. Fisher-Dzoga, R. Hughes, and L. Dubien. 1974. Regression of atherosclerosis in rabbits Part 1. Treatment with low-fat diet, hyperoxia and hypolipidemic agents. Atherosclerosis 19: 259–275.
Stary, H.C., and J.P. Strong. 1976. Coronary artery fine structure in rhesus monkeys: Nonatherosclerotic intimai thickening. Primates in Medicine, vol. 9, pp. 321–358, Karger, Basel.
Stary, H.C. 1972. Progression and regression of experimental atherosclerosis in rhesus monkeys. In: Medical Primatology 1972, part III. Ed. by E.I. Goldsmith and J. Moor-Jankowski, Karger, Basel, pp. 356–367.
Stary, H.C. 1976. Coronary artery fine structure in rhesus monkeys: The early atherosclerotic lesion and its progression. Primates in Medicine, vol. 9, pp. 359–395, Karger, Basel.
Abell, L.L., B.B. Levy, B.B. Brodie, and F.E. Kendall. 1952. A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J. Biol. Chem. 195: 357–366.
Scott, R.F., R. Jones, A.S. Daoud, O. Zumbo, F. Coulston, and W.A. Thomas. 1967. Experimental atherosclerosis in rhesus monkeys II. Cellular elements of proliferative lesions and possible role of cytoplasmic degeneration in pathogenesis as studied by electron microscopy. Exp. Molec. Path. 7: 34–57.
Tucker, C.F., C. Catsulis, J.P. Strong, and D.A. Eggen. 1971. Regression of early cholesterol-induced aortic lesions in rhesus monkeys. Amer. J. Path. 65: 493–514.
Geer, J.C. 1965. Fine structure of human aortic intimai thickening and fatty streaks. Lab. Invest. 14: 1764–1783.
Geer, J.C., and W.S. Webster. 1974. Morphology of mesenchymal elements of normal artery, fatty streaks, and plaques. Adv. Exp. Med. Biol., vol. 43, pp. 9–33, Plenum Press, New York.
Stary, H.C. 1974. Proliferation of arterial cells in atherosclerosis. Adv. Exp. Med. Biol., vol. 43, pp. 59–81, Plenum Press, New York.
Stary, H.C. 1974. Cell proliferation and ultrastructural changes in regressing atherosclerotic lesions after reduction of serum cholesterol. In: Atherosclerosis III. Ed. by G. Schettler and A. Weizel, Springer-Verlag, Berlin, pp. 187–190.
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Stary, H.C., Strong, J.P. (1976). The Fine Structure of Nonatherosclerotic Intimal Thickening, of Developing, and of Regressing Atherosclerotic Lesions at the Bifurcation of the Left Coronary Artery. In: Day, C.E. (eds) Atherosclerosis Drug Discovery. Advances in Experimental Medicine and Biology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4618-7_5
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DOI: https://doi.org/10.1007/978-1-4614-4618-7_5
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