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Evaluation of the Permeability Parameters (Influx, Efflux and Volume of Distribution) of Arterial Wall for LDL and Other Proteins

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Atherosclerosis Drug Discovery

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 67))

Abstract

Atherosclerosis is generally considered to be a multifactorial disease; as such, the prevention or cure of the disease may be approached at different levels, control of serum cholesterol or β-lipoprotein being an important one. However, the ultimate manifestation of the disease is in the arterial wall, and any prospective drug will have to be effective in producing the beneficial action at the arterial level. From this point of view it is of great importance to be able to monitor the effect of a drug on the relevant processes at the arterial wall. For the present discussion the arterial permeability to serum proteins, low density lipoprotein (LDL) in particular, will be taken as the relevant process.

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Authors and Affiliations

  1. Departments of Biochemistry and Medicine, Northwestern University Medical School, Chicago, IL, USA

    S. Ghosh, J. N. Finkelstein, D. B. Moss & J. S. Schweppe

Authors
  1. S. Ghosh
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  2. J. N. Finkelstein
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  3. D. B. Moss
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  4. J. S. Schweppe
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Editor information

Editors and Affiliations

  1. Atherosclerosis Research, The Upjohn Company, Kalamazoo, Michigan, USA

    Charles E. Day

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© 1976 Springer Science+Business Media New York

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Ghosh, S., Finkelstein, J.N., Moss, D.B., Schweppe, J.S. (1976). Evaluation of the Permeability Parameters (Influx, Efflux and Volume of Distribution) of Arterial Wall for LDL and Other Proteins. In: Day, C.E. (eds) Atherosclerosis Drug Discovery. Advances in Experimental Medicine and Biology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4618-7_11

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  • DOI: https://doi.org/10.1007/978-1-4614-4618-7_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9309-3

  • Online ISBN: 978-1-4614-4618-7

  • eBook Packages: Springer Book Archive

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