Cholinergic Effects of Angiotensin and Bradykinin

  • Jean-Claude Panisset
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 2)


Investigations of the stimulating effect of angiotensin on isolated intestinal preparations have suggested that part of its action on the smooth muscle is mediated through the release of acetylcholine (1, 2). In a recent report on the effects of angiotensin on the superior cervical ganglion of the cat, we postulated that the stimulating effect of small doses of this polypeptide on the nictitating membrane contraction and on ganglionic transmission was mediated through a cholinergic pathway affecting preganglionic nerve endings (3). In order to test this hypothesis, we first studied the effect of angiotensin on the release of acetylcholine using the isolated and perfused cat’s superior cervical ganglion preparation.


Superior Cervical Ganglion Cholinergic Effect Chorda Tympani Acetylcholine Chloride Cervical Sympathetic Trunk 
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Copyright information

© Springer Science+Business Media New York 1968

Authors and Affiliations

  • Jean-Claude Panisset
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of MontrealMontrealCanada

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