Cholinergic Effects of Angiotensin and Bradykinin
Investigations of the stimulating effect of angiotensin on isolated intestinal preparations have suggested that part of its action on the smooth muscle is mediated through the release of acetylcholine (1, 2). In a recent report on the effects of angiotensin on the superior cervical ganglion of the cat, we postulated that the stimulating effect of small doses of this polypeptide on the nictitating membrane contraction and on ganglionic transmission was mediated through a cholinergic pathway affecting preganglionic nerve endings (3). In order to test this hypothesis, we first studied the effect of angiotensin on the release of acetylcholine using the isolated and perfused cat’s superior cervical ganglion preparation.
KeywordsMorphine Polypeptide Angiotensin Choline Acetylcholine
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