“Vasodilating Action of Caerulein and I.C.I. 50,123 on the Canine Pancreatic Vascular Bed”

  • A. H. Glässer
  • L. Dorigotti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 2)

Abstract

Caerulein is a decapeptide isolated from the skin of the Ausstralian frog Hyla caerulea (1). The determination of the aminoacid sequence and subsequent synthesis have been carried out in these laboratories (2). According to Erspamer et al. (3) this pep tide causes a long-lasting blood pressure fall and has gastrin and pancreozymin-like activities on gall bladder motility and on gastric and pancreatic secretions. In the dog, caerulein stimulates external pancreatic secretion at doses as low as 3–6 ng/kg i. v. and decreases blood pressure at doses of 10–100 ng/kg i. v.

Keywords

Polypeptide Angiotensin Gall Ather Bradykinin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1).
    Erspamer V. and Anastasi Ada: In “Hypotensive Peptides”, pag. 63, Springer Verlag, New York Inc., 1966.CrossRefGoogle Scholar
  2. 2).
    Bernardi L. and Anastasi Ada: In “The Proceedings of this Symposium.Google Scholar
  3. 3).
    Erspamer V. et al.: Experientia (in press) 1967.Google Scholar
  4. 4).
    Wormsley K.G. et al.: Lancet, i, 993, 1966.CrossRefGoogle Scholar
  5. 5).
    Haigh A.L. et al.: J. Physiol. (London), 191, 45P, 1967.Google Scholar
  6. 6).
    Miller M.E. et al.: In “Anatomy of the Dog”, pag. 350, W.B. Saunders & Co., Philadelphia, 1964.Google Scholar
  7. 7).
    White F.N. and Ross G.: Am. J. Physiol., 210, 1118, 1966.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1968

Authors and Affiliations

  • A. H. Glässer
    • 1
  • L. Dorigotti
    • 1
  1. 1.FARMITALIA - Istituto RicercheMilanoItaly

Personalised recommendations