Skip to main content
SpringerLink
Log in
SpringerLink
Log in

The Role of Cyclic AMP in the Action of Insulin

  • Chapter
Pharmacology of Hormonal Polypeptides and Proteins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 2))

Abstract

It is now clear that not all the biological effects of insulin are caused by an increased rate of transport of sugars and amino acids across the cell membrane. One well documented effect that does not depend upon a stimulation of glucose metabolism is the antilipolytic action in adipose tissue which can be observed when rat epididymal fat pads are incubated in a glucose-free medium (1). Insulin has also been shown to increase the fraction in the independent (I) form of glycogen synthetase in rat diaphragm incubated in a medium without added substrate (2). Recently, Jungas (3) reported that insulin increased the percentage of the I form of glycogen synthetase in incubated adipose tissue and decreased the activity of adipose tissue glycogen Phosphorylase assayed without added 5′-AMP.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. JUNGAS, R. L. and BALL, E.G. (1963). Biochemistry 2, 383.

    Article  PubMed  CAS  Google Scholar 

  2. CRAIG, J.W. and LARNER, J. (1964). Nature, 202, 971.

    Article  PubMed  CAS  Google Scholar 

  3. JUNGAS, R. L. (1966). Proc. Natl. Acad. Sci. 56, 757.

    Article  PubMed  CAS  Google Scholar 

  4. BUTCHER, R. W., HO, R. J., MENG, H. C. and SUTHERLAND, E. W. (1965). J. Biol. Chem., 240, 4515.

    PubMed  CAS  Google Scholar 

  5. SUTHERLAND, E. W. and RAIL, T. W. (1960). Pharm. Rev., 12, 265.

    CAS  Google Scholar 

  6. ROSELL-PEREZ, M. and LARNER, J. (1964). Biochemistry, 3, 81.

    Article  PubMed  CAS  Google Scholar 

  7. CROFFORD, O. B. and RENOLD, A. E. (1965). J. Biol. Chem., 240, 14.

    PubMed  CAS  Google Scholar 

  8. JEFFERSON, L. S., JR., EXTON, J. H., BUTCHER, R. W., SUTHERLAND, E. W. and PARK, C.R. (1967). J. Biol. Chem., in press.

    Google Scholar 

  9. BUTCHER, R. W., PIKE, J. E. and SUTHERLAND, E. W. (1967). Proc. Nobel Symposium II. S. Bergstrom and B. Sammuelson, Eds., John Wiley and Sons, N. Y.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, Vanderbilt University, Nashville, Tennessee, USA

    J. G. T. Sneyd, J. D. Corbin & C. R. Park

Authors
  1. J. G. T. Sneyd
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. D. Corbin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. R. Park
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

  2. Institute of Pharmacology, University of Milan, Milan, Italy

    Luciano Martini

  3. Institute of Pharmacology, University of Cagliari, Cagliari, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1968 Springer Science+Business Media New York

About this chapter

Cite this chapter

Sneyd, J.G.T., Corbin, J.D., Park, C.R. (1968). The Role of Cyclic AMP in the Action of Insulin. In: Back, N., Martini, L., Paoletti, R. (eds) Pharmacology of Hormonal Polypeptides and Proteins. Advances in Experimental Medicine and Biology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4612-5_43

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-4612-5_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2726-2

  • Online ISBN: 978-1-4614-4612-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation