Advertisement

Effects of Digestive Secretagogues on the Endocrine Pancreas in Man

  • J. Dupré
  • J. D. Curtis
  • R. Waddell
  • J. C. Beck
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 2)

Abstract

The rate of disposal of glucose administered to normal man by way of the gastrointestinal tract is greater than that of glucose given intravenously (1, 2, 3). This phenomenon is associated with potentiation of the increase in blood insulin in response to a rise in blood glucose concentration (4, 5). It has also been shown that ingestion of glucose or infusion of glucose into the duodenum in man provokes a rise in plasma glucagon-like immunoreactivity (GLI), whereas intravenous infusion of glucose results in no change or a fall in this activity (6, 7). The effect of alimentary glucose on glucose disposal (3) and blood insulin (8) are not impaired by portacaval anastomosis with ligation of the portal vein. Peripheral hyperglycaemia produced by infusions of glucose into peripheral or portal veins has been found to have equivalent effects on blood immunoreactive insulin (IRI) and GLI in man (9). It therefore appears that features distinguishing the response to ingested glucose from that to glucose administered intravenously, are not related to portal hyperglycaemia and probably depend upon alimentary function. These findings have revived the question of the possible role of humoral agents derived from the intestine in the regulation of the endocrine function of the pancreas, a problem that was the subject of extensive but inconclusive investigation in the past (10).

Keywords

Insulin Secretion Blood Glucose Concentration Blood Insulin Pancreatic Glucagon Glucose Disappearance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  1. 1.
    O. Soramersalo (1950). Acta Paediat. (Helsinki), Supp. 78Google Scholar
  2. 2.
    V. Conard (1955). Acta Gastroenterol., Belg. 18: 655.Google Scholar
  3. 3.
    J. Dupré (1964). Lancet ii: 672.CrossRefGoogle Scholar
  4. 4.
    N. McIntyre, C. D. Holdsworth, D. S. Turner (1964). Lancet ii: 20.CrossRefGoogle Scholar
  5. 5.
    H. Elrick, L. Stimmler, C. J. Hlad, Y. Arai (1964). J. Clin. Endocrinol. 24: 1076.CrossRefGoogle Scholar
  6. 6.
    E. Samols, J. Tyler, A. Marri, V. Marks (1965). Lancet ii: 1257.CrossRefGoogle Scholar
  7. 7.
    A. M. Lawrence (1966). Proc. Nat. Acad. Sci. (U.S.A.) 55: 316.CrossRefGoogle Scholar
  8. 8.
    N. McIntyre, C. D. Holdsworth, D. S. Turner (1965). J. Clin. Endocrinol. 25: 1317.CrossRefGoogle Scholar
  9. 9.
    J. Dupré, L. Rojas, R. H. Unger, J. J. White, J. C. Beck (1965). Programme 26th Annual Meeting, American Diabetes Association, p. 29.Google Scholar
  10. 10.
    E. R. Loev, J. S. Gray, A. C. Ivy (1940). Am. J. Physiol. 129: 659.Google Scholar
  11. 11.
    J. Dupré, J. C. Beck (1965). Diabetes 15: 555.Google Scholar
  12. 12.
    J. Dupré, L. Rojas, J. J. White, R. H. Unger, J.C Beck (1966). Lancet ii: 26.CrossRefGoogle Scholar
  13. 13.
    R. H. Unger, M. Ketterer, J. Dupré, A. M. Elsentraut (1967). J. Clin. Invest. 46: 630.PubMedCrossRefGoogle Scholar
  14. 14.
    R. H. Unger et al. (1967). Proceedings of 6th Congress of International Diabetes Federation (in press).Google Scholar
  15. 15.
    E. Samols, V. Marks (1967). Proceedings of 6th Congress of International Diabetes Federation (in press).Google Scholar
  16. 16.
    R. H. Unger et al. (1967). Proceedings of 6th Congress of International Diabetes Federation (in press).Google Scholar
  17. 17.
  18. 18.
    P. Sum and R. Preshaw (1967). Lancet ii: 340.CrossRefGoogle Scholar
  19. 19.
    L. Kinsell (1967). Proceedings of 6th Congress of International Diabetes Federation (in press).Google Scholar
  20. 20.
    D. R. Boyns, R. J. Jarrett and H. Keen (1967). British Med. J. i: 676.CrossRefGoogle Scholar
  21. 21.
    S. J. Rune (1967). Clin. Sci. 32: 443.PubMedGoogle Scholar
  22. 22.
    J. C. Floyd, S. S. Fajans, S. Pek, C. A. Thiffault, R. F. Knopf, J. W. Conn (1967). Excerpta Medica Int. Cong. Series No. 140, p. 73.Google Scholar
  23. 23.
    J. C. Floyd, S. S. Fajans, J. W. Conn, R. F. Knopf, J. Rull (1966). J. Clin. Invest. 45: 1479 and 1487.PubMedCrossRefGoogle Scholar
  24. 24.
    S. Berger and S. Vargaraya (1966). Diabetes 15: 303.PubMedGoogle Scholar
  25. 25.
    T. J. Merimee, J. A. Burgess, D. Rabinowitz (1966). Lancet i: 1300.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1968

Authors and Affiliations

  • J. Dupré
    • 1
  • J. D. Curtis
    • 1
  • R. Waddell
    • 1
  • J. C. Beck
    • 1
  1. 1.Fraser Laboratory for Research in Diabetes, McGill, University ClinicRoyal Victoria HospitalMontrealCanada

Personalised recommendations