Studies on the Mechanism of Action of Hypothalamic FSH- and LH-Releasing Factors

  • M. Jutisz
  • A. Berault
  • M. P. de la Llosa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 2)


Although hypothalamic LH- and FSH- releasing factors (LRF and FRF) have been discovered since 1960 (1, 2, 3, 4, 5) and 1964 (6, 7, 8) respectively, only a little work was done until now on their mechanism of action. Three possibilities at least can be envisaged (9): 1, a stimulation of excretion (or discharge) of hormone stored in the pituitary, 2. a direct or indirect action on synthesis of hormone in the appropriate cells, 3. an effedt on activation of hormonal precursors.


Pituitary Tissue Ovarian Weight Estradiol Benzoate Incubation Process Hormonal Precursor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    HARRIS, E.W.., in Control of ovulation, C.A. VILLEE ed., Pergamon Press, London 1961, p. 56.Google Scholar
  2. 2.
    MCCANN, S.M., S. TALEISNIK and H.M. FRIEDMAN, Proc. Soc. Exptl. Biol. Med., 104: 432, 1960.CrossRefGoogle Scholar
  3. 3.
    CAMPBELL, H.J., C. FEUER, G. GARCIA and G.W. HARRIS, J. Physiol., London, 157: 30P, 1961.Google Scholar
  4. 4.
    McCANN, S.M. and S. TALEISNIK, Endocrinology, 68: 1071, 1961.CrossRefGoogle Scholar
  5. 5.
    COURRIER, R., R. GUILLEMIN, M. JUTISZ, E. SAKIZ and P. ASCHHEIM, C.R. Acad. Sc, Paris, 253: 922, 1961.Google Scholar
  6. 6.
    IGARASHI, M. and S.M. McCANN, Endocrinology, 74: 446, 1964.PubMedCrossRefGoogle Scholar
  7. 7.
    MITTLER, J.C. and J. MEITES, Proc. Soc. Exptl. Biol. Med., 117: 309, 1964.CrossRefGoogle Scholar
  8. 8.
    KUROSHIMA, A., Y. ISHIDA, C.Y. BOWERS and A.V. SCHALLY, Endocrinology, 76: 614, 1965.PubMedCrossRefGoogle Scholar
  9. 9.
    JUTISZ, M., A. BERAULT, M.-A. NOVELLA and F. CHAPEVILLE, C.R. Acad. Sc., Paris, 263: Ser. D, 664, 1966.Google Scholar
  10. 10.
    GUILLEMIN, R., M. JUTISZ and E. SAKIZ, C.R. Acad. Sc., Paris, 256: 504, 1963.Google Scholar
  11. 11.
    JUTISZ, M., A. BERAULT, M.-A. NOVELLA and G. RIBOT, Acta Endocrinol., 55: 481, 1967.PubMedGoogle Scholar
  12. 12.
    SCHALLY, A.V. and C.Y. BOWERS, Endocrinology, 75: 312, 1964.PubMedCrossRefGoogle Scholar
  13. 13.
    RAMIREZ, V.D. and S.M. McCANN, Endocrinology, 73: 193, 1963.PubMedCrossRefGoogle Scholar
  14. 14.
    PARLOW, A.F., in Human pituitary gonadotropins. A. Albert ed., C.C. Thomas, Springfield, Ill., 1961, p. 300.Google Scholar
  15. 15.
    STEELMAN, S.L. and F.M. POHLEY, Endocrinology, 53: 604, 1953.PubMedCrossRefGoogle Scholar
  16. 16.
    JUTISZ, M. and M.P. de la LLOSA, Endocrinology, accepted for publication.Google Scholar
  17. 17.
    de la LLOSA, P., C. COURTE and M. JUTISZ, Biochem. Biophys. Res. Commun., 26: 411, 1967.PubMedCrossRefGoogle Scholar
  18. 18.
    JUTISZ, M. and M.P. de la LLOSA, C.R. Acad. Sc., Paris, 264: Ser. D, 118, 1967.Google Scholar
  19. 19.
    SAMLI, M.H. and I.I. GESCHWIND, Program of the 49th Meeting of the Endocrine Society, 1967, no.59.Google Scholar
  20. 20.
    DAVID, M.A., F. FRASCHINI and L. MARTINI, Experientia, 21: 483, 1965.PubMedCrossRefGoogle Scholar
  21. 21.
    CORBIN, A. and J. STORY, Experientia, 22: 694, 1966.PubMedCrossRefGoogle Scholar
  22. 22.
    KUROSHIMA, A., A. ARIMURA, T. SAITO, Y. ISHIDA, C.Y. BOWERS and A.V. SCHALLY, Endocrinology, 78: 1105, 1966.PubMedCrossRefGoogle Scholar
  23. 23.
    SAITO, T., A. ARIMURA, E.E. MULLER, C.Y. BOWERS and A.V. SCHALLY, Endocrinology, 80: 313, 1967.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1968

Authors and Affiliations

  • M. Jutisz
    • 1
  • A. Berault
    • 1
  • M. P. de la Llosa
    • 1
  1. 1.Laboratoire de Morphologie Expérimentale et EndocrinologieCollège de FranceParis V°France

Personalised recommendations