Mechanism of Release and Mechanism of Action of Vasopressin

  • Niels A. Thorn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 2)


Vasopressin and oxytocin or one or several precursors of them are produced in the pericarya of cells in certain nuclei of the hypothalamus and maybe also within the axons leading from these cell bodies to the neural lobe of the pituitary. The hormones or their precursors are transported in neurosecretory granules from the perikarya of the cells to the neural lobe where they are stored and from where the controlled release takes place. The appropriate (or inappropriate) stimuli for release produce nerve signals, the last pathway of which is the nerve membrane surrounding the terminal swellings of the axon. There is no information on the speed with which the neurosecretory granules move within the axons.


Frog Skin Iodoacetic Acid Neurosecretory Granule Pinocytotic Vesicle Releasable Pool 
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  1. Barer, R. & K. Lederis: Zeitschr. f. Zellf. 75:201, 1966CrossRefGoogle Scholar
  2. Bargmann, W. et al.: Zeitschr. f. Zellf. 77:282, 1967CrossRefGoogle Scholar
  3. Bentley, P.: J. Endocrinol. 18:327, 1959.CrossRefGoogle Scholar
  4. Bie, P. & N.A. Thorn: Acta endocr. 56:139, 1967PubMedGoogle Scholar
  5. Bozler, E.: Amer. J. Physiol. 197:505, 1959PubMedGoogle Scholar
  6. Dean, C. R. et al.: Biochem. J. 104:8c, 1967Google Scholar
  7. Douglas, W. W. et al.: J. Physiol. 181:753, 1965PubMedGoogle Scholar
  8. Fukuda, T. R.: J. cell. comp. Physiol. 7:301, 1936CrossRefGoogle Scholar
  9. Gill, J. R., Jr & F. C. Bartter: J. clin. Invest. 40:716, 1961PubMedCrossRefGoogle Scholar
  10. Ginsburg, M. & M. Ireland: J. Endocrinol. 35:289, 1966PubMedCrossRefGoogle Scholar
  11. Holter, H.: Physiologie der Pinocytose bei Amoben in: Wohlfarth — Bottermann, K. E. (ed.): Sekretion und Exkretion. Springer Verlag 1965Google Scholar
  12. Lassiter, W. E. et al.: Pflugers Arch. 285:90, 1965CrossRefGoogle Scholar
  13. Pigeon, G. & F. H. Epstein: Amer. J. Physiol. 204:217, 1963PubMedGoogle Scholar
  14. Robinson, J. D.: Nature 212:199, 1966PubMedCrossRefGoogle Scholar
  15. Rudinger, J.: Excerpta Medica Congr. Ser. 83:1202, 1964Google Scholar
  16. Sachs, H.: Amer. J. Med. 42:687, 1967PubMedCrossRefGoogle Scholar
  17. Sanyal, N.N. & R.S. Snart: Nature 1:798, 1966Google Scholar
  18. Thorn, N.A.: Danish Med. Bull. 7:109, 1960Google Scholar
  19. Thorn, N.A.: Acta endocr. 38:563, 1961PubMedGoogle Scholar
  20. Thorn, N.A. & I.L. Schwartz: Gen. Comp. Endocr. 5:710, 1965Google Scholar
  21. Thorn, N. A.: Acta Endocr. 53:644, 1966PubMedGoogle Scholar
  22. Whittembury, G. et al.: Nature 187:699, 1960PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1968

Authors and Affiliations

  • Niels A. Thorn
    • 1
  1. 1.Institute of Medical Physiology CUniversity of CopenhagenDenmark

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