Mitochondria in the Aging Heart

  • José Marín-García


Aging is associated with progressive impairment of a variety of vital functions, resulting in an increased vulnerability to environmental challenges and a growing risk of disease and death. Cardiac aging, in particular, reduces cardiac functional reserve and predisposes the heart to stress, serving as one of the major risk factors for cardiovascular diseases (e.g., left ventricular hypertrophy, fibrosis, diastolic dysfunction). Thus, aging contributes to increased cardiovascular mortality in the elderly. During the last two decades, several different molecular pathways involved in the aging process have been revealed, and mitochondria were pointed out as one of the key regulators of longevity. Aging of cardiac tissue is accompanied by accumulation of mitochondrial protein oxidation, increased mitochondrial DNA mutations, deterioration of the respiratory chain function, and changes in mitochondrial biogenesis. Respiratory chain-deficient cells are more susceptible to undergo apoptosis, and increased cell loss is likely to be associated with the age-associated mitochondrial dysfunction.


Electron Transport Chain Mitochondrial Permeability Transition Pore Mitochondrial Permeability Transition Pore Adenine Nucleotide Translocator Cardiac Mitochondrion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • José Marín-García
    • 1
  1. 1.The Molecular Cardiology and Neuromuscular InstituteHighland ParkUSA

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