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Introduction to Mitochondria in the Heart

  • José Marín-García
Chapter

Abstract

In this introductory chapter to Mitochondria Role in Cardiovascular Diseases, we will discuss those primary defects in mitochondrial and nuclear genomes that cause alterations in major aspects of mitochondrial metabolism. They include defects in OXPHOS and TCA cycle activity and regulation, mitochondrial membrane proteins, channels and transporters, transcription, translation and posttranslation modification factors, mitochondrial ribosomal proteins, mtDNA replication and repair, as well as mitochondrial dynamic. How these defects contribute to pathogenesis of cardiovascular diseases will be described in detail later in dedicated chapters.

Keywords

Mitochondrial Biogenesis Mitochondrial Permeability Transition Pore Mitochondrial Permeability Transition Pore Adenine Nucleotide Translocase Cardiac Mitochondrion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • José Marín-García
    • 1
  1. 1.The Molecular Cardiology and Neuromuscular InstituteHighland ParkUSA

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