Sexual Networks and Sexually Transmitted Infections; “The Strength of Weak (Long Distance) Ties”

  • Ann M. JollyEmail author
  • John L. Wylie


Social networks are natural social units of people (nodes, actors) linked directly or indirectly to others by interaction, affections, associations or relationships and, for the purposes of this chapter, sexual intercourse. Sexual networks through which sexually transmitted pathogens are transmitted form the centre of this review of sexual networks. The fundamental concept of a social network is that the collection of links (paths or edges) and nodes forms an entity far greater than the sum of its parts [1], including interdependent norms, members, organisation and culture.


Census Tract Network Member Transmission Network Giant Component Sexual Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors thank Ms. Aristea Kokkinos for her precise and painstaking help with the references.


  1. 1.
    Klovdahl AS. Social networks and the spread of infectious diseases: the AIDS example. Soc Sci Med. 1985;21(11):1203–16.PubMedCrossRefGoogle Scholar
  2. 2.
    Wylie JL, Jolly A. Patterns of chlamydia and gonorrhea infection in sexual networks in Manitoba, Canada. Sex Transm Dis. 2001;28(1):14–24.PubMedCrossRefGoogle Scholar
  3. 3.
    De Rubeis E, Wylie JL, Cameron DW, Nair RC, Jolly AM. Combining social network analysis and cluster analysis to identify sexual network types. Int J STD AIDS. 2007; 18(11):754–59.;
  4. 4.
    Zimmerman HL, Potterat JJ, Dukes RL, et al. Epidemiologic differences between chlamydia and gonorrhea. Am J Public Health. 1990;80(11):1338–42.PubMedCrossRefGoogle Scholar
  5. 5.
    Rice RJ, Roberts PL, Handsfield HH, Holmes KK. Sociodemographic distribution of gonorrhea incidence: implications for prevention and behavioral research. Am J Public Health. 1991;81:1252–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Klovdahl AS, Potterat J, Woodhouse D, Muth J, Muth S, Darrow WW. HIV infection in an Urban Social Network: a progress report. Bull Methodol Sociol. 1992;36:24–33.Google Scholar
  7. 7.
    Wasserheit JN, Aral SO. The dynamic topology of sexually transmitted disease epidemics: implications for prevention strategies. J Infect Dis. 1996;174(2):S201–13.PubMedCrossRefGoogle Scholar
  8. 8.
    Potterat JJ, Meheus A, Gallwey J. Partner notification: operational considerations. Int J STD AIDS. 1991;2(6):411–5.PubMedGoogle Scholar
  9. 9.
    Rothenberg R. The transformation of partner notification. Clin Infect Dis. 2002;35(2):S138–45. Scholar
  10. 10.
    Karp G, Schlaeffer F, Jotkowitz A, Riesenberg K. Syphilis and HIV co-infection. Eur J Intern Med. 2009;20(1):9–13. doi: 10.1016/j.ejim.2008.04.002.PubMedCrossRefGoogle Scholar
  11. 11.
    Auerbach DM, Darrow WW, Jaffe HW, Curran JW. Cluster of cases of the acquired immune deficiency syndrome; patients linked by sexual contact. Am J Med. 1984;76:487–92.PubMedCrossRefGoogle Scholar
  12. 12.
    Rothenberg RB, Potterat JJ, Holmes KK, Mardh P, Sparling PF, et al., editors. Strategies for management of sex partners; sexually transmitted diseases. Vol. 2. New York: McGraw-Hill; 1990. p. 1081–86.Google Scholar
  13. 13.
    Canadian guidelines on sexually transmitted infections. Ottawa, ON: Public Health Agency of Canada; 2006.Google Scholar
  14. 14.
    Sexually transmitted diseases treatment guidelines, 2006. MMWR Morb Mortal Wkly Rep. 2006;55(RR-11):1–100.Google Scholar
  15. 15.
    Brewer DD. Case-finding effectiveness of partner notification and cluster investigation for sexually transmitted diseases/HIV. Sex Transm Dis. 2005;32(2):78–83.PubMedCrossRefGoogle Scholar
  16. 16.
    Langille DB, Shoveller J. Partner notification and patient education for cases of Chlamydia trachomatis infection in a rural Nova Scotia health unit. Can J Public Health. 1992;83(5):358–61.PubMedGoogle Scholar
  17. 17.
    Rasooly I, Millson ME, Frank JW, et al. A survey of public health partner notification for sexually transmitted diseases in Canada. Can J Public Health. 1994;85 Suppl 1:S48–52.PubMedGoogle Scholar
  18. 18.
    Brewer DD, Webster CM. Forgetting of friends and its effect on measuring friendship networks. Soc Net. 1999;21:361–73.CrossRefGoogle Scholar
  19. 19.
    Brewer DD, Garrett SB, Kulasingam S. Forgetting as a cause of incomplete reporting of sexual and drug injection partners. Sex Transm Dis. 1999;26(3):166–76.PubMedCrossRefGoogle Scholar
  20. 20.
    Ogilvie G, Knowles L, Wong E, et al. Incorporating a social networking approach to enhance contact tracing in a heterosexual outbreak of syphilis. Sex Transm Infect. 2005;81(2):124–7.PubMedCrossRefGoogle Scholar
  21. 21.
    Annan T, Evans B, Hughes G. Guidance for managing STI outbreaks and incidents. London, UK: Health Protection Agency; 2008:12.Google Scholar
  22. 22.
    Ghani AC, Donnelly CA, Garnett GP. Sampling biases and missing data in explorations of sexual partner networks for the spread of sexually transmitted diseases. Stat Med. 1998;17(18):2079–97.PubMedCrossRefGoogle Scholar
  23. 23.
    Ramirez-Valles J, Heckathorn DD, Vázquez R, Diaz RM, Campbell RT. From networks to populations: the development and application of respondent-driven sampling among IDUs and Latino gay men. AIDS Behav. 2005;9(4):387–402.
  24. 24.
    Heckathorn DD. Respondent-driven sampling: a new approach to the study of hidden populations. Soc Probl. 1997;44(2):174–99.
  25. 25.
    Heckathorn DD. Respondent-driven sampling II: deriving valid population estimates from chain-referral samples of hidden populations. Soc Probl. 2002;49(1):11–34.
  26. 26.
    Abdul-Quader AS, Heckathorn DD, Sabin K, Saidel T. Implementation and analysis of respondent driven sampling: lessons learned from the field. J Urban Health. 2006;83(1 Suppl):1–5.
  27. 27.
    Salganik MJ, Heckathorn DD. Making unbiased estimates from hidden populations using respondent-driven sampling. Sunbelt Social Network Conference, Cancun, Mexico; 2003.Google Scholar
  28. 28.
    Potterat JJ, Rothenberg RB, Woodhouse DE, Muth JB, Pratts CI, Fogle JS. Gonorrhea as a social disease. Sex Transm Dis. 1985;12(1):25–32.PubMedCrossRefGoogle Scholar
  29. 29.
    Granovetter M. The strength of weak ties. Am J Sociol. 1973;78(6):1360–80.CrossRefGoogle Scholar
  30. 30.
    McPherson M, Smith-Lovin L, Cook JM. Birds of a feather: homophily in social networks. Annu Rev Sociol. 2001;27(1):415–44.
  31. 31.
    Blanchard JF, Moses S, Greenaway C, Orr P, Hammond GW, Brunham RC. The evolving epidemiology of chlamydial and gonococcal infections in response to control programs in Winnipeg, Canada. Am J Public Health. 1998;88(10):1496–502.PubMedCrossRefGoogle Scholar
  32. 32.
    Rothenberg RB. The geography of gonorrhea. Am J Epidemiol. 1983;117:688–94.PubMedGoogle Scholar
  33. 33.
    Rothenberg R, Muth SQ, Malone S, Potterat JJ, Woodhouse DE. Social and geographic distance in HIV risk. Sex Transm Dis. 2005;32(8):506–12. Scholar
  34. 34.
    Aral SO, Hughes JP, Stoner B, et al. Sexual mixing patterns in the spread of gonococcal and chlamydial infections. Am J Public Health. 1999;89(6):825–33.PubMedCrossRefGoogle Scholar
  35. 35.
    Rothenberg R. The relevance of social epidemiology in HIV/AIDS and drug abuse research. Am J Prev Med. 2007;32(6 Suppl 1):S147–53.
  36. 36.
    Bush KR, Henderson EA, Dunn J, Read RR, Singh A. Mapping the core: chlamydia and gonorrhea infections in Calgary, Alberta. Sex Transm Dis. 2008;35(3):291–97. 00007435-200803000-00015&D=ovftj. 10.1097/OLQ.0b013e31815c1edb.Google Scholar
  37. 37.
    Laumann EO, Gagnon JH, Michael RT, Michaels S. The social organization of sexuality: sexual practices in the United States. Chicago, IL: University of Chicago Press; 1994. p. 750.Google Scholar
  38. 38.
    Wallace R, Fullilove MT, Flisher AJ. AIDS, violence and behavioral coding: information theory, risk behavior and dynamic process on core-group sociogeographic networks. Soc Sci Med. 1996;43(3):339–52.PubMedCrossRefGoogle Scholar
  39. 39.
    Ellen JM, Langer LM, Zimmerman RS, Cabral RJ, Fichtner R. The link between the use of crack cocaine and the sexually transmitted diseases of a clinic population. A comparison of adolescents with adults. Sex Transm Dis. 1996;23(6):511–6.PubMedCrossRefGoogle Scholar
  40. 40.
    Jennings JM, Luo RF, Lloyd LV, Gaydos C, Ellen JM, Rietmeijer CA. Age-bridging among young, urban, heterosexual males with asymptomatic Chlamydia trachomatis. Sex Transm Infect. 2007;83(2):136–41.;
  41. 41.
    Foulkes HB, Pettigrew MM, Livingston KA, Niccolai LM. Comparison of sexual partnership characteristics and associations with inconsistent condom use among a sample of adolescents and adult women diagnosed with Chlamydia trachomatis. J Womens Health (Larchmt). 2009;18(3):393–99.
  42. 42.
    Yorke JA, Hethcote HW, Nold A. Dynamics and control of the transmission of gonorrhea. Sex Transm Dis. 1978;5(2):51–6.PubMedCrossRefGoogle Scholar
  43. 43.
    Brunham RC. The concept of core and its relevance to the epidemiology and control of sexually transmitted diseases [editorial]. Sex Transm Dis. 1991;18(2):67–8.PubMedCrossRefGoogle Scholar
  44. 44.
    Liljeros F, Edling CR, Amaral LAN, Stanley HE, Aberg Y. The web of human sexual contacts. Nature. 2001;411(6840):907–8. Scholar
  45. 45.
    Schneeberger A, Nat R, Mercer CH, et al. Scale-free networks and sexually transmitted diseases: a description of observed patterns of sexual contacts in Britain and Zimbabwe. Sex Transm Dis. 2004;31(6):380–7.PubMedCrossRefGoogle Scholar
  46. 46.
    Eames KTD, Keeling MJ. Monogamous networks and the spread of sexually transmitted diseases. Math Biosci. 2004;189(2):115–30.PubMedCrossRefGoogle Scholar
  47. 47.
    Newman M. Power laws, Pareto distributions and Zipf’s law. Contemp Phys. 2005;46(5):323–51. Scholar
  48. 48.
    Chan DYC, Hughes BD, Leong AS, Reed WJ. Stochastically evolving networks. Phys Rev E. 2003;68(066124):066124-4–24.Google Scholar
  49. 49.
    Britton T, Nordvik MK, Liljeros F. Modelling sexually transmitted infections: the effect of partnership activity and number of partners on R0. Theor Popul Biol. 2007;72(3):389–99.PubMedCrossRefGoogle Scholar
  50. 50.
    Gorbach PM, Drumright LN, Holmes KK. Discord, discordance, and concurrency: comparing individual and partnership-level analyses of new partnerships of young adults at risk of sexually transmitted infections. Sex Transm Dis. 2005;32(1):7–12.PubMedCrossRefGoogle Scholar
  51. 51.
    Stoner BP, Whittington WL, Hughes JP, Aral SO, Holmes KK. Comparative epidemiology of heterosexual gonococcal and chlamydial networks: implications for transmission patterns. Sex Transm Dis. 2000;27(4):215–23.PubMedCrossRefGoogle Scholar
  52. 52.
    Quinn RW, O’Reilly KR, Khaw M. Gonococcal infections in women attending the venereal disease clinic of the Nashville Davidson County Metropolitan Health Department, 1984. South Med J. 1988;81:851–4.PubMedCrossRefGoogle Scholar
  53. 53.
    Moran JS, Aral SO, Jenkins WC, Peterman TA, Alexander ER. The impact of sexually transmitted diseases on minority populations. Public Health Rep. 1989;104(6):560–5.PubMedGoogle Scholar
  54. 54.
    Zenilman JM. Gonorrhea, chlamydia and the sexual network: pushing the envelope. Sex Transm Dis. 2000;27(4):224–5.PubMedCrossRefGoogle Scholar
  55. 55.
    Jolly AM, Muth SQ, Wylie JL, Potterat JJ. Sexual networks and sexually transmitted infections: a tale of two cities. J Urban Health. 2001;78(3):433–45.PubMedCrossRefGoogle Scholar
  56. 56.
    Laumann EO, Youm Y. Racial/ethnic group differences in the prevalence of sexually transmitted diseases in the United States: a network explanation [see comments]. Sex Transm Dis. 1999;26(5):250–61.PubMedCrossRefGoogle Scholar
  57. 57.
    Fichtenberg CM, Muth SQ, Brown B, Padian NS, Glass TA, Ellen JM. Sexual network structure among a household sample of urban African American ­adolescents in an endemic sexually transmitted infection setting. Sex Transm Dis. 2009;36(1):41–8.PubMedCrossRefGoogle Scholar
  58. 58.
    Jolly AM, Moffatt MEK, Fast MV, Brunham RC. Sexually transmitted disease thresholds in Manitoba, Canada. Ann Epidemiol. 2005;15(10):781–8. Scholar
  59. 59.
    Williams ML, Atkinson J, Klovdahl A, Ross MW, Timpson S. Spatial bridging in a network of drug-using male sex workers. J Urban Health. 2005;82:i35–42. Scholar
  60. 60.
    Donohue JF. Problems posed by population mobility in control of syphilis. In: Proceedings of the world forum on syphilis and other trepanematoses. Atlanta, GA: U.S. Department of Health, Education and Welfare; 1964:38.Google Scholar
  61. 61.
    Nordvik MK, Liljeros F, Osterlund A, Herrmann B. Spatial bridges and the spread of chlamydia: the case of a County in Sweden. Sex Transm Dis. 2007;34(1):47–53.
  62. 62.
    Wylie JL, Cabral T, Jolly AM. Identification of networks of sexually transmitted infection: a molecular, geographic, and social network analysis. J Infect Dis. 2005;191(6):899–906. Scholar
  63. 63.
    Kerani RP, Golden MR, Whittington WLH, Handsfield HH, Hogben M, Holmes KK. Spatial bridges for the importation of gonorrhea and chlamydial infection. Sex Transm Dis. 2003;30(10):742–9.PubMedCrossRefGoogle Scholar
  64. 64.
    Calzavara LM, Bullock SL, Myers T, Marshall VW, Cockerill R. Sexual partnering and risk of HIV/STD among Aboriginals. Can J Public Health. 1999;90(3):186–91.PubMedGoogle Scholar
  65. 65.
    Brunham RC, Cheang M, McMaster J, Garnett G, Anderson R. Chlamydia trachomatis, infertility, and population growth in sub-Saharan Africa [see comments]. Sex Transm Dis. 1993;20(3):168–73.PubMedCrossRefGoogle Scholar
  66. 66.
    Boily MC, Brunham RC. The impact of HIV and other STDs on human populations. Are predictions possible? [published erratum appears in Infect Dis Clin North Am 1994 Jun;8(2):xi-xii]. Infect Dis Clin North Am. 1993;7(4):771–92.PubMedGoogle Scholar
  67. 67.
    Anderson RM, Ng TW, Boily MC, May RM. The influence of different sexual-contact patterns between age classes on the predicted demographic impact of AIDS in developing countries. Ann N Y Acad Sci. 1989;569:240–74.PubMedCrossRefGoogle Scholar
  68. 68.
    Ellen JM, Brown BA, Chung S, et al. Impact of sexual networks on risk for gonorrhea and chlamydia among low-income urban African American adolescents. J Pediatr. 2005;146(4):518–22. Scholar
  69. 69.
    Morris M, Zavisca J, Dean L. Social and sexual networks: their role in the spread of HIV/AIDS among young gay men. AIDS Educ Prev. 1995;7(5 Suppl):24–35.PubMedGoogle Scholar
  70. 70.
    Service SK, Blower SM. HIV transmission in sexual networks: an empirical analysis. Proc R Soc Lond B Biol Sci. 1995;260(1359):237–44.CrossRefGoogle Scholar
  71. 71.
    De P, Singh AE, Wong T, Yacoub W, Jolly AM. Sexual network analysis of a gonorrhoea outbreak. Sex Transm Infect. 2004;80(4):280–5.PubMedCrossRefGoogle Scholar
  72. 72.
    Watts DJ, Strogatz SH. Collective dynamics of ‘small-world’ networks. Nature. 1998;393(6684):440–2.PubMedCrossRefGoogle Scholar
  73. 73.
    Barabasi AL, Bonabeau E. Scale-free networks. Sci Am. 2003;288(5):60–9.PubMedCrossRefGoogle Scholar
  74. 74.
    Wylie JL, Maclean I, Brunham R, Craig C, Jolly AM. Gonorrhea types and sexual networks in Manitoba, Canada. Sunbelt XIX International Sunbelt Social Network Conference. 1999.Google Scholar
  75. 75.
    Ward H, Ison CA, Day SE, et al. A prospective social and molecular investigation of gonococcal transmission. Lancet. 2000;356(9244):1812–7.PubMedCrossRefGoogle Scholar
  76. 76.
    Liao M, Bell K, Gu WM, et al. Clusters of circulating Neisseria gonorrhoeae strains and association with antimicrobial resistance in Shanghai. J Antimicrob Chemother. 2008;61(3):478–87.PubMedCrossRefGoogle Scholar
  77. 77.
    Martin IM, Ison CA, Aanensen DM, Fenton KA, Spratt BG. Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area. J Infect Dis. 2004;189(8):1497–505.PubMedCrossRefGoogle Scholar
  78. 78.
    Fredlund H, Falk L, Jurstrand M, Unemo M. Molecular genetic methods for diagnosis and characterisation of Chlamydia trachomatis and Neisseria gonorrhoeae: impact on epidemiological surveillance and interventions. APMIS. 2004;112(11–12):117–84.Google Scholar
  79. 79.
    Falk L, Lindberg M, Jurstrand M, Backman A, Olcen P, Fredlund H. Genotyping of Chlamydia trachomatis would improve contact tracing. Sex Transm Dis. 2003;30(3):205–10.PubMedCrossRefGoogle Scholar
  80. 80.
    Cabral T, Jolly AM, Wylie JL. Chlamydia trachomatis omp1 genotypic diversity and concordance with sexual network data. J Infect Dis. 2003;187(2):279–86.
  81. 81.
    Anderson RM. Wasserheit JN, Aral SO, Holmes KK, Hitchcock PJ, editors. The transmission dynamics of sexually transmitted diseases: the behavioral component; Research issues in human behavior and sexually transmitted diseases in the AIDS era. Vol Ist. Washington, DC: American Society for Microbiology; 1991:38–60.Google Scholar
  82. 82.
    Anderson RM, May RM. Infectious diseases of humans; dynamics and control. Vol 1st. Oxford, England: Oxford University Press; 1992:234.Google Scholar
  83. 83.
    Brunham RC, Plummer FA. A general model of sexually transmitted disease epidemiology and its implications for control. Med Clin North Am. 1990;74(6):1339–52.PubMedGoogle Scholar
  84. 84.
    Holmes KK, Johnson DW, Trostle HJ. An estimate of the risk of men acquiring gonorrhea by sexual contact with infected females. Am J Epidemiol. 1970;91(2):170–4.PubMedGoogle Scholar
  85. 85.
    Hook EW, Handsfield HH, Holmes KK, Mardh P, Sparling PF, et al. editors. Gonococcal infections in the adult; sexually transmitted diseases. Vol 2nd. Toronto: McGraw-Hill Information Services Co; 1992:149–65.Google Scholar
  86. 86.
    Stigum H, Magnus P, Bakketeig LS. Effect of ­changing partnership formation rates on the spread of sexually transmitted diseases and human immunodeficiency virus. Am J Epidemiol. 1997;145(7):644–52.PubMedCrossRefGoogle Scholar
  87. 87.
    McCormack WM, Alpert S, McComb DE, Nichols RL, Semine DZ, Zinner SH. Fifteen month follow-up study of women infected with Chlamydia trachomatis. N Engl J Med. 1979;300(5):123–5.PubMedCrossRefGoogle Scholar
  88. 88.
    Garnett GP, Aral SO, Hoyle DV, Cates W, Anderson Jr RM. The natural history of syphilis. Implications for the transmission dynamics and control of infection [see comments]. Sex Transm Dis. 1997;24(4):185–200.PubMedCrossRefGoogle Scholar
  89. 89.
    Schroeter et al. Therapy for incubating syphilis: effectiveness of gonorrhea treatment. JAMA. 1971;218(5):711. Accessed 6 May 2010.
  90. 90.
    Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet. 2001;357(9263):1149–53.PubMedCrossRefGoogle Scholar
  91. 91.
    Renton AM, Whitaker L, Riddlesdell M. Heterosexual HIV transmission and STD prevalence: predictions of a theoretical model. Sex Transm Infect. 1998;74(5):339–44.PubMedCrossRefGoogle Scholar
  92. 92.
    Rothenberg R. Change your friends. Addiction. 2006;101(7):913–4, discussion 914.Google Scholar
  93. 93.
    Potterat JJ, ZimmermanRogers H, Muth SQ, et al. Chlamydia transmission: concurrency, reproduction number, and the epidemic trajectory. Am J Epidemiol. 1999;150(12):1331–9.PubMedCrossRefGoogle Scholar
  94. 94.
    Communicable Disease Control. Manitoba health. Sexually transmitted disease control. Winnipeg, Manitoba; 1997.Google Scholar
  95. 95.
    Potterat JJ, Muth SQ, Rothenberg RB, et al. Sexual network structure as an indicator of epidemic phase. Sex Transm Infect. 2002;78 Suppl 1:I152–8.PubMedCrossRefGoogle Scholar
  96. 96.
    Jolly AM, Wylie JL. Sampling individuals with large sexual networks – an evaluation of four approaches. Sex Transm Dis. 2001;28(4):200–7.PubMedCrossRefGoogle Scholar
  97. 97.
    Potterat JJ, Muth SQ, Rothenberg RB. Sexual network structure as an indicator of epidemic phase. Sex Transm Infect. 2002;78 Suppl 1:I152–8.PubMedCrossRefGoogle Scholar
  98. 98.
    Jolly AM, Wylie JL. Gonorrhoea and chlamydia core groups and sexual networks in Manitoba. Sex Transm Infect. 2002;78 Suppl 1:I145–51.PubMedCrossRefGoogle Scholar
  99. 99.
    CDC. Sexually transmitted diseases treatment guidelines – 2002. MMWR Morb Mortal Wkly Rep. 2002;51:1–80.Google Scholar
  100. 100.
    Schachter J, Stephens RS. Biology of Chlamydia trachomatis. In: Holmes KK, Sparling PF, Stamm WE, et al., editors. Sexually transmitted diseases. 4th ed. New York, NY: McGraw Hill; 2008. p. 555–74.Google Scholar
  101. 101.
    Iskrant AP, Kahn HA. Statistical indices used in the evaluation of syphilis contact investigation. J Vener Dis Inf. 1948;29(1):1–6.PubMedGoogle Scholar
  102. 102.
    Martin I, Gu W, Yang Y, Tsang R. Macrolide resistance and molecular types of Treponema pallidum causing primary syphilis in Shanghai, China. Clin Infect Dis. 2009;49(4):515–21.
  103. 103.
    Leitner T, Escanilla D, Franzen C, Uhlen M, Albert J. Accurate reconstruction of a known HIV-1 transmission history by phylogenetic tree analysis. Proc Natl Acad Sci USA. 1996;93(20):10864–9.PubMedCrossRefGoogle Scholar
  104. 104.
    Paraskevis D, Magiorkinis E, Magiorkinis G, et al. Phylogenetic reconstruction of a known HIV-1 CRF04_cpx transmission network using maximum likelihood and Bayesian methods. J Mol Evol. 2004;59(5):709–17. doi: 10.1007/s00239-004-2651-6.PubMedCrossRefGoogle Scholar
  105. 105.
    European Centre for Disease Prevention and Control. Annual epidemiological report on communicable diseases in Europe. 2009:69–71.Google Scholar
  106. 106.
    Brown WJ, U.S. Department of Health, Education and Welfare, Public Health Sevice, Communicable Disease Center, editors. The first step toward eradication. In: Proceedings of the World Forum on Syphilis and other Trepanematoses. Atlanta: U.S. Department of Health, Education and Welfare; 1964:21–5.Google Scholar
  107. 107.
    Primary and secondary syphilis – United States 2002. MMWR Morb Mortal Wkly Rep. 2003;52(46):1117–20.Google Scholar
  108. 108.
    Knapper CM, Roderick J, Smith J, Temple M, Birley HDL. Investigation of an HIV transmission cluster centred in South Wales. Sex Transm Infect. 2008;84(5):377–380.
  109. 109.
    Northern Ireland, Department of Health and Social Security. Syphilis outbreak. Communicable Diseases Monthly Report (Northern Ireland). 2001;10(9):1–3.Google Scholar
  110. 110.
    Leber A, MacPherson P, Lee BC. Epidemiology of infectious syphilis in Ottawa: recurring themes revisited. Can J Public Health. 2008;99(5):401–5. Scholar
  111. 111.
    Jayaraman GC, Read RR, Singh AE. Characteristics of individuals with male-to-male and heterosexually acquired infectious syphilis during an outbreak in Calgary, Alberta, Canada. Sex Transm Dis. 2003;30(4):315–9.PubMedCrossRefGoogle Scholar
  112. 112.
    Patrick DM, Rekart ML, Jolly A, et al. Heterosexual outbreak of infectious syphilis: epidemiological and ethnographic analysis and implications for control. Sex Transm Infect. 2002;78(1):164–9.CrossRefGoogle Scholar
  113. 113.
    2004 Canadian sexually transmitted infections surveillance report. Can Commun Dis Rep. 2007;33S1:1–69.Google Scholar
  114. 114.
    Rothenberg RB, Sterk C, Toomey KE, et al. Using social network and ethnographic tools to evaluate syphilis transmission. Sex Transm Dis. 1998;25(3):154–60.PubMedCrossRefGoogle Scholar
  115. 115.
    Ogilvie G, Taylor D, Moniruzzaman A, et al. A population based study of infectious syphilis rediagnosis in British Columbia, 1995–2005. Clin Infect Dis. 2009;48(11):1554–58.
  116. 116.
    Haraldsdottir S, Gupta S, Anderson RM. Preliminary studies of sexual networks in a male homosexual community in Iceland. J Acquir Immune Defic Syndr. 1992;5(4):374–81.PubMedGoogle Scholar
  117. 117.
    Adam BD, Husbands W, Murray J, Maxwell J. Circuits, networks, and HIV risk management. AIDS Educ Prev. 2008;20(5):420–34.PubMedCrossRefGoogle Scholar
  118. 118.
    Rothenberg R. Commentary – how a net works – implications of network structure for the persistence and control of sexually transmitted diseases and HIV. Sex Transm Dis. 2001;28(2):63–8.PubMedCrossRefGoogle Scholar
  119. 119.
    Potterat JJ, Phillips-Plummer L, Muth SQ, et al. Risk network structure in the early epidemic phase of HIV transmission in Colorado Springs. Sex Transm Infect. 2002;78 Suppl 1:I159–63.PubMedCrossRefGoogle Scholar
  120. 120.
    Walter T, Lebouche B, Miailhes P, et al. Symptomatic relapse of neurologic syphilis after benzathine ­penicillin G therapy for primary or secondary syphilis in HIV-infected patients. Clin Infect Dis. 2006;43(6):787–90.PubMedCrossRefGoogle Scholar
  121. 121.
    Brewer DD. Supplementary interviewing techniques to maximize output in free listing tasks. Field Methods. 2002;14(1):108–18. doi: 10.1177/1525822X02014001007.CrossRefGoogle Scholar
  122. 122.
    Brewer DD, Garrett SB, Rinaldi G. Free-listed items are effective cues for eliciting addition items in semantic domains. Appl Cognitive Psychol. 2002:343–58.Google Scholar
  123. 123.
    Zimmerman-Rogers H, Potterat JJ, Muth SQ, et al. Establishing efficient partner notification periods for patients with chlamydia. Sex Transm Dis. 1999;26(1):49–54.PubMedCrossRefGoogle Scholar
  124. 124.
    Rothenberg R, Narramore J. The relevance of social network concepts to sexually transmitted disease control. Sex Transm Dis. 1996;23(1):24–9.PubMedCrossRefGoogle Scholar
  125. 125.
    Remple VP, Patrick DM, Johnston C, Tyndall MW, Jolly AM. Clients of indoor commercial sex ­workers: heterogeneity in patronage patterns and implications for HIV and STI propagation through sexual networks. Sex Transm Dis. 2007;34(10):754–60.PubMedGoogle Scholar
  126. 126.
    Rekart ML, Patrick DM, Chakraborty B, et al. Targeted mass treatment for syphilis with oral azithromycin. Lancet. 2003;361(9354):313–4. doi: 10.1016/S0140-6736(03)12335-5.PubMedCrossRefGoogle Scholar
  127. 127.
    Broadhead RS, Heckathorn DD, Weakliem DL, et al. Harnessing peer networks as an instrument for AIDS prevention: results from a peer-driven intervention. Public Health Rep. 1998;113 Suppl 1:42–57.Google Scholar
  128. 128.
    Amirkhanian YA, Kelly JA, McAuliffe TL. Identifying, recruiting, and assessing social networks at high risk for HIV/AIDS: methodology, practice, and a case study in St Petersburg, Russia. AIDS Care. 2005;17(1):58–75.
  129. 129.
    Kelly JA, Amirkhanian YA, Kabakchieva E, et al. Prevention of HIV and sexually transmitted diseases in high risk social networks of young Roma (Gypsy) men in Bulgaria: randomised controlled trial. BMJ. 2006;333(7578):1098–1101.
  130. 130.
    Darrow WW, Potterat JJ, Rothenberg RB, Woodhouse DE, Muth SQ. Using knowledge of social networks to prevent human immunodeficiency virus infections: the Colorado Springs Study. Sociol Focus. 1999;32(2):143–58.CrossRefGoogle Scholar

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Infectious Disease Emergency Preparedness Branch, Public Health Agency of CanadaCentre for Communicable Disease and Infection ControlOttawaCanada
  2. 2.Cadham Provincial LaboratoryWinnipegCanada

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