Approach to the Patient with Nephrotic Syndrome

  • Leslie F. Thomas
  • Harini A. Chakkera


A 50-year-old woman with no significant past medical history acutely develops bilateral lower extremity pitting edema. A thorough evaluation of cardiac and hepatic functions is unremarkable; however, urinalysis reveals significant proteinuria. Further testing shows an elevated serum creatinine level of 1.8 mg/dL, low serum albumin level of 2.2 g/dL, and hyperlipidemia (total cholesterol 385 mg/dL, triglycerides 480 mg/dL, LDL 245 mg/dL, and HDL 44 mg/dL). Urinary protein measures 5.2 g in a 24-h collection. The clinical diagnosis of nephrotic syndrome is made.


Nephrotic Syndrome Membranous Nephropathy Minimal Change Disease Glomerular Filtration Barrier Elevated Serum Creatinine Level 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Nephrology and HypertensionMayo Clinic ArizonaPhoenixUSA

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