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Abstract

A 32-year-old thin woman is complaining of weakness and light-headedness. She denies vomiting and intake of medications except vitamins. On physical examination she has a blood pressure of 100/60 mmHg with a heart rate of 95 beats/min and diminished skin turgor. The remainder of her exam is unremarkable. Laboratory data are shown in Table 13.1.

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References

  1. Stone DJ. Respiration in man during metabolic alkalosis. J Appl Physiol. 1962;17:33–7.

    PubMed  CAS  Google Scholar 

  2. Javaheri S, Kazemi H. Metabolic alkalosis and hypoventilation in humans. Am Rev Respir Dis. 1987;136:1011–6.

    Article  PubMed  CAS  Google Scholar 

  3. Hodgkin JE, Soeprono FF, Chan DM. Incidence of metabolic alkalemia in hospitalized patients. Crit Care Med. 1980;8:725–8.

    Article  PubMed  CAS  Google Scholar 

  4. Anderson LE, Henrich WL. Alkalemia-associated morbidity and mortality in medical and surgical patients. South Med J. 1987;80:729–33.

    Article  PubMed  CAS  Google Scholar 

  5. Galla JH. Metabolic alkalosis. J Am Soc Nephrol. 2000;11:369–75.

    PubMed  CAS  Google Scholar 

  6. Rosen RA, Julian BA, Dubovsky EV, Galla JH, Luke RG. On the mechanism by which chloride corrects metabolic alkalosis in man. Am J Med. 1988;84:449–58.

    Article  PubMed  CAS  Google Scholar 

  7. Gifford JD, Ware MW, Luke RG, Galla JH. HCO3− transport in rat CCD: rapid adaptation by in vivo but not in vitro alkalosis. Am J Physiol. 1993;264:F435–40.

    PubMed  CAS  Google Scholar 

  8. Wagner CA, Finberg KE, Stehberger PA, Lifton RP, Giebisch GH, Aronson PS, Geibel JP. Regulation of the expression of the Cl−/anion exchanger pendrin in mouse kidney by acid-base status. Kidney Int. 2002;62:2109–17.

    Article  PubMed  CAS  Google Scholar 

  9. Riccio JF, Irani FA. Posthypercapnic metabolic alkalosis: common and neglected cause. South Med J. 1979;72:886–7.

    Article  PubMed  CAS  Google Scholar 

  10. Simonetti GD, Mohaupt MG, Bianchetti MG. Monogenic forms of hypertension. Euro J pediatr 2011;14 March online first.

    Google Scholar 

  11. Sontia B, Mooney J, Gaudet L, Touyz RM. Pseudohyperaldosteronism, liquorice, and hypertension. J Clin Hypertens (Greenwich). 2008;10:153–7.

    Article  Google Scholar 

  12. Kaufman AM, Kahn T. Potassium-depletion alkalosis in the rat. Am J Physiol. 1988;255:F763–70.

    PubMed  CAS  Google Scholar 

  13. Chen YS, Fang HC, Chou KJ, Lee PT, Hsu CY, Huang WC, Chung HM, Chen CL. Gentamicin-induced Bartter-like syndrome. Am J Kidney Dis. 2009;54:1158–61.

    Article  PubMed  Google Scholar 

  14. Chadha V, Alon US. Hereditary renal tubular disorders. Semin Nephrol. 2009;29:399–411.

    Article  PubMed  CAS  Google Scholar 

  15. Patel AM, Goldfarb S. Got calcium? Welcome to the calcium-alkali syndrome. J Am Soc Nephrol. 2010;21:1440–3.

    Article  PubMed  CAS  Google Scholar 

  16. Litchfield WR, New MI, Coolidge C, Lifton RP, Dluhy RG. Evaluation of the dexamethasone suppression test for the diagnosis of glucocorticoid-remediable aldosteronism. J Clin Endocrinol Metab. 1997;82:3570–3.

    Article  PubMed  CAS  Google Scholar 

  17. Fraser R. Disorders of the adrenal cortex: their effects on electrolyte metabolism. Clin Endocrinol Metab. 1984;13:413–30.

    Article  PubMed  CAS  Google Scholar 

  18. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill Jr JR, Ulick S, Milora RV, Findling JW, et al. Liddle’s syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell. 1994;79:407–14.

    Article  PubMed  CAS  Google Scholar 

  19. Eiro M, Katoh T, Watanabe T. Use of a proton-pump inhibitor for metabolic disturbances associated with anorexia nervosa. N Engl J Med. 2002;346:140.

    Article  PubMed  Google Scholar 

  20. Aichbichler BW, Zerr CH, Santa Ana CA, Porter JL, Porter JL, Fordtran JS. Proton-pump inhibition of gastric chloride secretion in congenital chloridorrhea. N Engl J Med. 1997;336:106–9.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Luis M. Ortega M.D. .

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Ortega, L.M., Lenz, O. (2013). Metabolic Alkalosis. In: Lerma, E., Rosner, M. (eds) Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4454-1_13

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  • DOI: https://doi.org/10.1007/978-1-4614-4454-1_13

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