Abstract
Because of the unique anatomy of the digestive system of ruminant animals, drug delivery technologies can be designed to be retained in the rumen for prolonged periods permitting drug release for durations of up to 12 months (or even longer). Since the beginning of the 1980s different technologies have been developed to prolong the release of antibiotics, anthelmintics, trace elements, growth promoting agents, and minerals to the rumen of cattle and sheep. Successful development of intraruminal devices must take into account the anatomy and physiology at the site of drug release from the technology and the disease state the drug is treating. The formulation scientist should have a sound knowledge of physical pharmacy and an appreciation of plastic product design. This chapter describes historical and recently developed long acting veterinary rumen technologies, defines the relevance of the anatomy and physiology of the rumen to the development of a ruminal drug delivery technology, provides an insight into the disease state of nematode infestation as an example of a clinical condition for which long acting drug products have commercial value, and describes a case study of a delivery system that was developed specifically to deliver anthelmintic compounds for the treatment of nematode infestations.
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Vandamme, T.F., Rathbone, M.J. (2013). Long Acting Rumen Drug Delivery Systems. In: Rathbone, M., McDowell, A. (eds) Long Acting Animal Health Drug Products. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4439-8_10
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DOI: https://doi.org/10.1007/978-1-4614-4439-8_10
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