Skip to main content

Micro Flows in the Cardiopulmonary System: A Surgical Perspective

  • Chapter
  • First Online:
Micro and Nano Flow Systems for Bioanalysis

Part of the book series: Bioanalysis ((BIOANALYSIS,volume 2))

  • 1329 Accesses

Abstract

Micro-flows in different organs—i.e., the flow of blood through the smallest vessels, the microcirculation—differ in a number of aspects from blood flow in larger vessels. Most prominently, the vessels of the microcirculation exhibit diameters which are comparable in diameter to the size of red blood cells. In addition to these hemorheological differences, the vessels of the microcirculation exhibit the largest fraction of the overall inner vessel surface which is covered by the endothelium. This chapter focuses on the heart and the lung addressing phenomena in the microcirculation, including the no reflow phenomenon, coronary microvascular dysfunction in the heart and the hypoxic pulmonary vasoconstriction in the lung.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Marino PL (2007) Hypoxemia and hypercapnia. In: Marino PL (ed) The ICU book. Lippincott Williams & Wilkins, Philadelphia, PA, pp 367–383

    Google Scholar 

  2. D’Alonzo GE, Dantzger DR (1983) Mechanisms of abnormal gas exchange. Med Clin North Am 67:557–571

    Google Scholar 

  3. Buohuys A (1964) Respiratory dead space. In: Fenn W, Rahn H (eds) Handbook of physiology: respiration. American Physiological Society, Bethesda, MD, pp 699–714

    Google Scholar 

  4. Bugiardini R, Badimon L, Collins P, Erbel R, Fox K, Hamm C, Pinto F, Rosengren A, Stefanadis C, Wallentin L, Van de WF (2007) Angina, “normal” coronary angiography, and vascular dysfunction: risk assessment strategies. PLoS Med 4:e12

    Article  Google Scholar 

  5. Camici PG, Crea F (2007) Coronary microvascular dysfunction. N Engl J Med 356:830–840

    Article  Google Scholar 

  6. Chien S, Usami S, Skalak R (1984) Blood flow in small tubes. In: Renkin EM, Michel CC (eds) Handbook of physiology, section 2: the cardiovascular system, vol IV, The microcirculation. American Physiological Society, Bethesda, MD, pp 217–249

    Google Scholar 

  7. Dantzger DR (1991) Pulmonary gas exchange. In: Dantzger DR (ed) Cardiopulmonary critical care, 2nd edn. WB Saunders, Philadelphia, PA, pp 25–43

    Google Scholar 

  8. Jaffe R, Dick A, Strauss BH (2010) Prevention and treatment of microvascular obstruction-related myocardial injury and coronary no-reflow following percutaneous coronary intervention: a systematic approach. JACC Cardiovasc Interv 3:695–704

    Article  Google Scholar 

  9. Kuebler WM (2011) Real-time imaging assessment of pulmonary vascular responses. Proc Am Thorac Soc 8:458–465

    Article  Google Scholar 

  10. Katritsis D, Choi MJ, Webb-Peploe MM (1991) Assessment of the hemodynamic significance of coronary artery stenosis: theoretical considerations and clinical measurements. Prog Cardiovasc Dis 34(1):69–88

    Article  Google Scholar 

  11. Lanken PN (1995) Ventilation–perfusion relationship. In: Grippi MA (ed) Pulmonary pathophysiology. JB Lippincott, Philadelphia, PA, pp 195–210

    Google Scholar 

  12. Melikian N, de BB, Fearon WF, MacCarthy PA (2008) The pathophysiology and clinical course of the normal coronary angina syndrome (cardiac syndrome X). Prog Cardiovasc Dis 50:294–310

    Article  Google Scholar 

  13. Melikian N, Vercauteren S, Fearon WF, Cuisset T, MacCarthy PA, Davidavicius G, Aarnoudse W, Bartunek J, Vanderheyden M, Wyffels E, Wijns W, Heyndrickx GR, Pijls NH, de BB (2010) Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis. EuroIntervention 5:939–945

    Article  Google Scholar 

  14. Niccoli G, Burzotta F, Galiuto L, Crea F (2009) Myocardial no-reflow in humans. J Am Coll Cardiol 54:281–292

    Article  Google Scholar 

  15. Niccoli G, Kharbanda RK, Crea F, Banning AP (2010) No-reflow: again prevention is better than treatment. Eur Heart J 31:2449–2455

    Article  Google Scholar 

  16. Ochs M, Nyengaard JR, Jung A, Knudsen L, Voigt M, Wahlers T, Richter J, Gundersen HJG (2004) The number of alveoli in the human lung. Am J Respir Crit Care Med 169:120–124

    Article  Google Scholar 

  17. Pries AR, Habazettl H, Ambrosio G, Hansen PR, Kaski JC, Schachinger V, Tillmanns H, Vassalli G, Tritto I, Weis M, de WC, Bugiardini R (2008) A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings. Cardiovasc Res 80:165–174

    Article  Google Scholar 

  18. Rezkalla SH, Dharmashankar KC, Abdalrahman IB, Kloner RA (2010) No-reflow phenomenon following percutaneous coronary intervention for acute myocardial infarction: incidence, outcome, and effect of pharmacologic therapy. J Interv Cardiol 23:429–436

    Article  Google Scholar 

  19. Sylvester JT, Shimoda LA, Aaronson PI, Ward JP (2012) Hypoxic pulmonary vasoconstriction. Physiol Rev 92:367–520

    Article  Google Scholar 

  20. Tabuchi A, Mertens M, Kuppe H, Pries AR, Kuebler WM (2008) Intravital microscopy of the murine pulmonary microcirculation. J Appl Physiol 104:338–346

    Article  Google Scholar 

  21. Vaccarino V, Badimon L, Corti R, de WC, Dorobantu M, Hall A, Koller A, Marzilli M, Pries A, Bugiardini R (2011) Ischaemic heart disease in women: are there sex differences in pathophysiology and risk factors? Position paper from the working group on coronary pathophysiology and microcirculation of the European Society of Cardiology. Cardiovasc Res 90:9–17

    Article  Google Scholar 

  22. Vinten-Johansen J, Zhao ZQ, Guyton RA (2003) Cardiac surgical physiology. In: Cohn LH, Edmunds LH Jr (eds) Cardiac surgery in the adult. McGraw-Hill, New York, pp 53–84

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vasilios A. Karagounis .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Karagounis, V.A., Pries, A.R. (2013). Micro Flows in the Cardiopulmonary System: A Surgical Perspective. In: Collins, M., Koenig, C. (eds) Micro and Nano Flow Systems for Bioanalysis. Bioanalysis, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4376-6_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-4376-6_5

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-4375-9

  • Online ISBN: 978-1-4614-4376-6

  • eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)

Publish with us

Policies and ethics