Analysis of Sequential Clinical Trials

Chapter
Part of the Applied Bioinformatics and Biostatistics in Cancer Research book series (ABB)

Abstract

We discuss issues and methods for the analysis of clinical trials that have formal rules for what is commonly referred to as early stopping. However, we take a broader view, and include trials having a formal sequential stopping rule; the distinction will soon become apparent. Moreover, it is impossible to separate the analysis of such trials from their design, and so we must, of necessity, provide an overview of the design—that is, specification of the stopping rule—of a sequential clinical trial as well.

Keywords

Placebo Covariance Assure Stratification Blindness 

Notes

Acknowledgments

The services of Xiao Zhang with SAS programming, the Appendix, and the figures are gratefully acknowledged.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of Biostatistics and Computational BiologyUniversity of RochesterRochesterUSA

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