Abstract
Clinical observations during the 1980s suggested that brain death has a much greater impact on organ function in the potential organ donor—and after the organs are transplanted into the recipients—than previously anticipated. Extensive laboratory and clinical studies were initiated with regard to many aspects of the impact of brain death, including organ injury, depletion of energy stores, cytokine and inflammatory responses, and immunological sequelae.
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Wicomb W, Boyd ST, Cooper DK, Rose AG, Barnard CN. Ex vivo functional evaluation of pig hearts subjected to 24 hours’ preservation by hypothermic perfusion. S Afr Med J. 1981;60:245–8.
Wicomb WN, Cooper DKC, Barnard CN. Twenty-four hour preservation of the pig heart by a portable hypothermic perfusion system. Transplantation. 1982;34:246–50.
Wicomb W, Cooper DK, Hassoulas J, Rose AG, Barnard CN. Orthotopic transplantation of the baboon heart after 20 to 24 hours’ preservation by continuous hypothermic perfusion with an oxygenated hyperosmolar solution. J Thorac Cardiovasc Surg. 1982;83: 133–40.
Wicomb WN, Cooper DK, Novitzky D, Barnard CN. Cardiac transplantation following storage of the donor heart by a portable hypothermic perfusion system. Ann Thorac Surg. 1984;373:243–8.
Wicomb WN, Cooper DK, Novitzky D. An airlift pump device for low pressure perfusion storage of the isolated heart. Cryobiology. 1985;5:401–8.
Wicomb WN, Novitzky D, Cooper DK, Rose AG. Forty-eight hours hypothermic perfusion storage of pig and baboon hearts. J Surg Res. 1986;3:276–84.
Wicomb WN, Rose AG, Cooper DK, Novitzky D. Hemodynamic and myocardial histologic and ultrastructural studies on baboons from 3 to 27 months following autotransplantation of hearts stored by hypothermic perfusion for 24 or 48 hours. J Heart Transplant. 1986;5:122–9.
Cooper DK, Wicomb WN, Barnard CN. Storage of the donor heart by a portable hypothermic perfusion system: experimental development and clinical experience. J Heart Transplant. 1983;2:104–10.
Cooper DK, Wicomb WN, Rose AG, Barnard CN. Orthotopic allotransplantation and autotransplantation of the baboon heart following twenty-four hours storage by a portable hypothermic perfusion system. Cryobiology. 1983;20:385–94.
Cooper DK, Wicomb WN, Novitzky D. Cardiac transplantation following storage of the donor heart by a portable hypothermic perfusion system: the initial clinical experience. Clin Transpl. 2006;552–4.
Barnard CN, Losman JG. Left ventricular bypass. S Afr Med J. 1975;49:303–12.
Losman JG, Levine H, Campbell CD, Replogle RL, Hassoulas J, Novitzky D, et al. Changes in indications for heart transplantation. An additional argument for the preservation of the recipient’s own heart. J Thorac Cardiovasc Surg. 1982;84:716–26.
Novitzky D, Cooper DKC, Barnard CN. The surgical technique of heterotopic heart transplantation. Ann Thorac Surg. 1983;36:476–82.
Novitzky D, Cooper DKC, Barnard CN. Reversal of acute rejection by cyclosporine in a heterotopic heart transplant. J Heart Transplant. 1984;3:117–20.
Cooper DK, Novitzky D, Becerra E, Reichart B. Are there indications for heterotopic heart transplantation in 1986? A 2- to 11-year follow-up of 49 consecutive patients undergoing heterotopic heart transplantation. Thorac Cardiovasc Surg. 1986;34:300–4.
Becerra E, Cooper DK, Novitzky D, Reichart B. Are there indications for heterotopic heart transplantation today? Transplant Proc. 1987;19:2512–3.
Cooper DK, Romero Jr CA, Clark RM, Chaffin J, Greer A, Novitzky D, et al. Indications for heterotopic heart transplantation and report on two patients. J Okla State Med Assoc. 1988;81:513–7.
Novitzky D, Cooper DKC, Barnard CN. Circulatory assistance with allograft. Ann Thorac Surg. 1984;37:179.
Novitzky D, Cooper DK, Rose AG, Barnard CN. The value of recipient heart assistance during severe acute rejection following heterotopic cardiac transplantation. J Cardiovasc Surg. 1984;25:287–95.
Cushing H. Some experimental and clinical observations concerning states of increased intracranial tension. Am J Med Sci. 1902;124:373–400.
Shivalkar B, Van Loon J, Wieland W, Tjandra-Maga TB, Borgers M, Plets C, et al. Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function. Circulation. 1993;87:230–9.
Schrader H, Krogness K, Aakvaag A, Sortland O, Purvis K. Changes of pituitary hormones in brain death. Acta Neurochir. 1980;52:239–48.
Hall GM, Mashiter K, Lumley J, Robson JG. Hypothalamic-pituitary function in the ‘brain-dead’ patient. Lancet. 1980;2:1259.
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Novitzky, D., Cooper, D.K.C. (2013). Introduction. In: Novitzky, D., Cooper, D. (eds) The Brain-Dead Organ Donor. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4304-9_1
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DOI: https://doi.org/10.1007/978-1-4614-4304-9_1
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