Inflammatory Disease and Glaucoma

  • Sunita Radhakrishnan
  • Emmett T. CunninghamJr.
  • Andrew G. Iwach


Elevated intraocular pressure (IOP) is commonly associated with uveitis and may or may not cause optic nerve damage. The mechanism of IOP elevation in uveitis is multifactorial, and for clinical purposes it is helpful to consider the angle status as well as the timing of IOP elevation with respect to the onset of inflammation. Based on these factors, uveitis ocular hypertension or glaucoma may be classified as inflammatory ocular hypertension syndromes (IOHS), acute uveitic angle closure, corticosteroid-induced hypertension/glaucoma, and chronic mixed-mechanism ocular hypertension/glaucoma. Adequate treatment of the underlying inflammatory process is the primary goal in managing this challenging condition. Elevated IOP can be managed with many of the same strategies as primary open angle glaucoma with some key differences – prostaglandin analogs are usually the last choice, laser trabeculoplasty is contraindicated, surgical treatment of any type is associated with a higher risk of hypotony, there is a higher risk of failure of filtering procedures, and ciliodestructive procedures are best avoided due to the risk of phthisis.


Ocular Hypertension Trabecular Meshwork Anterior Uveitis Angle Closure Elevated Intraocular Pressure 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Sunita Radhakrishnan
    • 1
  • Emmett T. CunninghamJr.
    • 2
    • 3
    • 4
  • Andrew G. Iwach
    • 5
  1. 1.Glaucoma Center of San Francisco and Glaucoma Research and Education GroupSan MateoUSA
  2. 2.The Uveitis ServiceCalifornia Pacific Medical CenterSan FranciscoUSA
  3. 3.Department of OphthalmologyStanford University School of MedicineStanfordUSA
  4. 4.West Coast Retina Medical Group, Inc.San FranciscoUSA
  5. 5.Glaucoma Center of San FranciscoSan FranciscoUSA

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