Molecular Biology and Classification of Enteroviruses

Chapter

Abstract

Enteroviruses (members of the genus Enterovirus of the family Picornaviridae) have a positive-sense RNA genome enclosed in a naked, icosahedral capsid. They include notable pathogens such as poliovirus, which causes poliomyelitis, and rhinoviruses, the major cause of the common cold. Over 250 enterovirus serotypes capable of infecting humans have been identified. One Enterovirus species, Human enterovirus B, has for a long time been implicated in causing type 1 diabetes. These viruses use a range of cell receptors and similar viruses sometimes use quite different receptors. They also exhibit the ability to adapt to different receptors. Infection causes profound changes to cell processes, antivirus defence mechanisms and cell ultrastructure, usually leading to cell death. The flexibility in receptor usage and changes induced in the infected cell may well underpin the ability of these viruses to target and damage or kill the specific cells involved in type 1 diabetes.

Keywords

Hepatitis Carbohydrate Glycine Interferon Arginine 

References

  1. Alexander DA, Dimock K (2002) Sialic acid functions in enterovirus 70 binding and infection. J Virol 76:11265–11272PubMedCrossRefGoogle Scholar
  2. Choe SS, Dodd DA, Kirkegaard K (2005) Inhibition of cellular protein secretion by picornaviral 3A proteins. Virology 337:18–29PubMedCrossRefGoogle Scholar
  3. Coyne CB, Bergelson JM (2006) Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions. Cell 124:119–131PubMedCrossRefGoogle Scholar
  4. Goodfellow I, Chaudhry Y, Richardson A, Meredith J, Almond JW, Barclay W, Evans DJ (2000) Identification of a cis-acting replication element within the poliovirus coding region. J Virol 74:4590–4600PubMedCrossRefGoogle Scholar
  5. Goodfellow IG, Sioofy AB, Powell RM, Evans DJ (2001) Echoviruses bind heparan sulfate at the cell surface. J Virol 75:4918–4921PubMedCrossRefGoogle Scholar
  6. Harris JR, Racaniello VR (2005) Amino acid changes in proteins 2B and 3A mediate rhinovirus type 39 growth in mouse cells. J Virol 79:5363–5373PubMedCrossRefGoogle Scholar
  7. Karttunen A, Pöyry T, Vaarala O, Ilonen J, Hovi T, Roivainen M, Hyypiä T (2003) Variation in enterovirus receptor genes. J Med Virol 70:99–108PubMedCrossRefGoogle Scholar
  8. Katpally U, Smith TJ (2007) Pocket factors are unlikely to play a major role in the life cycle of human rhinovirus. J Virol 81:6307–6315PubMedCrossRefGoogle Scholar
  9. Knowles NJ (2011) Picornavirus home page. http://www.picornaviridae.com/. Accessed 2 Jan 2012
  10. Lin J-Y, Chen T-C, Weng K-F, Chang S-C, Chen L-L, Shih S-R (2009) Viral and host proteins involved in picornavirus life cycle. J Biomed Sci 16:103PubMedCrossRefGoogle Scholar
  11. Macadam AJ, Ferguson G, Stone DM, Meredith J, Knowlson S, Auda G, Almond JW, Minor PD (2006) Rational design of genetically stable, live-attenuated poliovirus vaccines of all three serotypes: relevance to poliomyelitis eradication. J Virol 80:8653–8663PubMedCrossRefGoogle Scholar
  12. Mercer J, Schelhaas M, Helenius A (2010) Virus entry by endocytosis. Annu Rev Biochem 79:803–833PubMedCrossRefGoogle Scholar
  13. Rossmann MG, He Y, Kuhn RJ (2002) Picornavirus-receptor interactions. Trends Microbiol 10:324–331PubMedCrossRefGoogle Scholar
  14. Sarnow P (2003) Viral Internal Ribosome Entry Site elements: novel ribosome-RNA complexes and roles in viral pathogenesis. J Virol 77:2801–2806PubMedCrossRefGoogle Scholar
  15. Stanway G, Brown F, Christian P, Hovi T, Hyypiä T, King AMQ, Knowles NJ, Lemon SM, Minor PD, Pallansch MA, Palmenberg AC, Skern T (2004) Picornaviridae. In: Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Balleditors LA (eds) Virus taxonomy, VIIIth report of the ICTV. Elsevier/Academic, London, pp p757–778Google Scholar
  16. Steil BP, Barton DJ (2009) Cis-active RNA elements (CREs) and picornavirus RNA replication. Virus Res 139:240–252PubMedCrossRefGoogle Scholar
  17. Tuthill TJ, Groppelli E, Hogle JM, Rowlands DJ (2011) Picornaviruses. Curr Top Microbiol Immunol 343:43–89CrossRefGoogle Scholar
  18. Whitton JL, Cornell CT, Feuer R (2005) Host and virus determinants of picornavirus pathogenesis and tropism. Nat Rev Microbiol 3:765–776PubMedCrossRefGoogle Scholar
  19. Witwer C, Rauscher S, Hofacker IL, Stadler PF (2001) Conserved RNA secondary structures in Picornaviridae genomes. Nucleic Acids Res 29:5079–5089PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Biological SciencesUniversity of EssexColchesterUK

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