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Metabolic Networks in Parkinson’s Disease

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Mechanisms and Emerging Therapies in Tremor Disorders

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

The idea that Parkinson’s disease (PD) is a “network” disorder has emerged alongside our evolving understanding of the basal ganglia’s complex interconnections. The notion of a direct and indirect pathway has remained an important concept even as we have increasingly come to acknowledge the oversimplifications of the construct. Fortunately, metabolic brain imaging with [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) has allowed us to explore and expand upon these network ideas in novel ways. The application of network-oriented image analysis to FDG PET provides valuable information concerning functional connectivity and is thus particularly well suited to the study of complex brain disorders like PD and related parkinsonian syndromes. In this chapter, we will review these PD-related metabolic networks along with their research and clinical applications.

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Author information

Authors and Affiliations

  1. Department of Neurology, North Shore University Hospital, Manhasset, NY, 11030, USA

    Michael Pourfar, Martin Niethammer & David Eidelberg

  2. Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA

    Martin Niethammer & David Eidelberg

Authors
  1. Michael Pourfar
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  2. Martin Niethammer
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  3. David Eidelberg
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Corresponding author

Correspondence to David Eidelberg .

Editor information

Editors and Affiliations

  1. , Unité d'Etude due Mouvement (UEM), Neurologie ULB Erasme, N/A, Bruxelles, N/A, Belgium

    Giuliana Grimaldi

  2. route de Lennik 808, Bruxelles, 1070, Belgium

    Mario Manto

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Pourfar, M., Niethammer, M., Eidelberg, D. (2013). Metabolic Networks in Parkinson’s Disease. In: Grimaldi, G., Manto, M. (eds) Mechanisms and Emerging Therapies in Tremor Disorders. Contemporary Clinical Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4027-7_22

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