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Infectious Disease Biomarkers: Non-Antibody-Based Host Responses

  • Audrey N. Schuetz
Chapter

Abstract

Biomarkers, or biologic markers, are measurable substances which are produced by the body in response to a particular infection, or a recent change in status of the patient. They are in vivo host responses which are indicative of the overall biological state of the patient at the time. According to the Definitions Biomarkers Working Group, a biomarker is “… a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention” [1]. Usually quantifiable, biomarkers include both antibody- and non-antibody-based host responses. This chapter focuses on the assessment and interpretation of non-antibody-based host responses which are produced by the patient in response to changes in homeostasis due to infection.

Keywords

Systemic Inflammatory Response Syndrome Lower Respiratory Tract Infection Biphasic Waveform Normal Biologic Process Noninfectious Systemic Inflammatory Response Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Departments of Pathology & Laboratory Medicine, and MedicineWeill Cornell Medical College/The NewYork-Presbyterian HospitalNew YorkUSA

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