Tubular Transport

  • Christopher J. Lote


In the previous chapter, the term “filtration” was defined, in the context of glomerular filtration. The fluid entering the nephron by glomerular filtration has a composition very similar to that of plasma, except that plasma proteins, which cannot readily cross the glomerular filter, are almost completely absent from the tubular fluid. However, the final urine which leaves the nephrons to enter the bladder and be excreted is very different from the initial glomerular filtrate, because the composition of the filtrate is modified by reabsorption and secretion of specific substances—i.e. there are selective reabsorption and secretion processes in the nephrons (Fig. 4.1).


Tight Junction Cystic Fibrosis Transmembrane Conductance Regulator Apical Membrane Proximal Tubule Cell Tubular Fluid 
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Further Reading

  1. King LS, Agre P (1996) Pathophysiology of the aquaporin water channels. Annu Rev Physiol 58:619–648PubMedCrossRefGoogle Scholar
  2. Van Itallie CM, Anderson JM (2004) The molecular physiology of tight junction pores. Physiology 19:331–338PubMedCrossRefGoogle Scholar
  3. Welling PA, Weisz OA (2010) Sorting it out in endosomes: an emerging concept in renal epithelial cell transport regulation. Physiology 25:280–292PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Christopher J. Lote
    • 1
  1. 1.College of Medical and Dental SciencesUniversity of BirminghamBirminghamUK

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