Core Concepts and Treatment of Metabolic Acidosis

  • Michael R. Wiederkehr
  • Orson W. Moe


Acid–base homeostasis constitutes one of the most fundamental biologic processes vital to survival of all life-forms. Derangements acid–base balance can result from a variety of causes and can exert multiple effects on many organs. Metabolic acidosis is a state of excess accumulation of acid in the body due to excess production, reduced excretion, or a combination of both. In this chapter, we summarize some basic acid–base chemistry and biology for the clinician, highlights how to utilize simple laboratory findings to approach metabolic acidosis, and finally discuss the evidence that supports the various treatment protocols and controversies in metabolic acidosis.


Chronic Kidney Disease Renal Replacement Therapy Metabolic Acidosis Lactic Acidosis Renal Tubular Acidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors are grateful to Ms. Vicki Perkins for her expert assistance in the preparation of the chapter. The authors are supported by the National Institutes of Health, The National Kidney Foundation, the Charles and Jane Pak Foundation, and the Simmons Family Foundation.


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of NephrologyBaylor University Medical CenterDallasUSA
  2. 2.Center for Mineral Metabolism and Clinical Research, UT Southwestern Medical CenterDallasUSA

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