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Treatment: Pharmacological, Repetitive Transcranial Magnetic Stimulation, Epidural Stimulation, and Deep Brain Stimulation

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Tinnitus

Part of the book series: Springer Handbook of Auditory Research ((SHAR,volume 44))

Abstract

Available treatments for the management of tinnitus are diverse. These include counseling and cognitive–behavioral therapies; different forms of sound therapies; methods that attempt to increase input to the auditory system, such as hearing aids and cochlear implants (for use in patients whose tinnitus is caused by deprivation of signals to the auditory nervous system); pharmacological treatment; neurobiofeedback; and various forms of electrical stimulation of brain structures, either through implanted electrodes or by inducing electrical current in the brain with transcranial magnetic stimulation. The existence of many different treatment approaches derives from the fact that there exist different subgroups of tinnitus that differ in their pathophysiology and their response to treatment. In clinical practice it is frequently difficult to choose the optimal treatment approach for an individual patient. The treatment approaches presented in this chapter (pharmacological, magnetic, or electrical brain stimulation) are all at early stages of development. The further development of these new treatment options will depend on the extent to which we understand the pathophysiology of the different forms of tinnitus.

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References

  • Adjamian, P., Sereda, M., & Hall, D. A. (2009). The mechanisms of tinnitus: Perspectives from human functional neuroimaging. Hearing Research, 253, 15–31.

    PubMed  Google Scholar 

  • Anders, M., Dvorakova, J., Rathova, L., Havrankova, P., Pelcova, P., Vaneckova, M., et al. (2010). Efficacy of repetitive transcranial magnetic stimulation for the treatment of refractory chronic tinnitus: A randomized, placebo controlled study. Neuroendocrinology Letters, 31, 238–249.

    PubMed  Google Scholar 

  • Arnold, W., Bartenstein, P., Oestreicher, E., Romer, W., & Schwaiger, M. (1996). Focal metabolic activation in the predominant left auditory cortex in patients suffering from tinnitus: A PET study with [18  F]deoxyglucose. Journal of Otorhinolaryngology and Related Specialities, 58, 195–199.

    CAS  Google Scholar 

  • Attias, J., Weisz, G., Almog, S., Shahar, A., Wiener, M., Joachims, Z., et al. (1994). Oral magnesium intake reduces permanent hearing loss induced by noise exposure. American Journal of Otolaryngology, 15, 26–32.

    PubMed  CAS  Google Scholar 

  • Azevedo, A. A., & Figueiredo, R. R. (2007). Treatment of tinnitus with acamprosate. Progress in Brain Research, 166, 273–277.

    PubMed  Google Scholar 

  • de Azevedo, A. A., Langguth, B., de Oliveira, P. M., & Rodrigues, F. R. (2009). Tinnitus treatment with piribedil guided by electrocochleography and acoustic otoemissions. Otology and Neurotology, 30, 676–680.

    PubMed  Google Scholar 

  • Baars, B. J., & Franklin, S. (2007). An architectural model of conscious and unconscious brain functions: Global Workspace Theory and IDA. Neural Networks, 20, 955–961.

    PubMed  Google Scholar 

  • Bahmad, F. M., Jr., Venosa, A. R., & Oliveira, C. A. (2006). Benzodiazepines and GABAergics in treating severe disabling tinnitus of predominantly cochlear origin. International Tinnitus Journal, 12, 140–144.

    PubMed  CAS  Google Scholar 

  • Bakhshaee, M., Ghasemi, M., Azarpazhooh, M., Khadivi, E., Rezaei, S., Shakeri, M., & Tale, M. (2008). Gabapentin effectiveness on the sensation of subjective idiopathic tinnitus: A pilot study. European Archives of Otorhinolaryngology, 265, 525–530.

    PubMed  Google Scholar 

  • Bao, S., Chan, V. T., & Merzenich, M. M. (2001). Cortical remodelling induced by activity of ventral tegmental dopamine neurons. Nature, 412, 79–83.

    PubMed  CAS  Google Scholar 

  • Barker, A. T., Jalinous, R., & Freeston, I. L. (1985). Non-invasive magnetic stimulation of human motor cortex. Lancet, 1, 1106–1107.

    PubMed  CAS  Google Scholar 

  • Bauer, C. A., & Brozoski, T. J. (2001). Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model. Journal of the Association of Research in Otolaryngology, 2, 54–64.

    CAS  Google Scholar 

  • Bauer, C. A., & Brozoski, T. J. (2006). Effect of gabapentin on the sensation and impact of tinnitus. Laryngoscope, 116, 675–681.

    PubMed  CAS  Google Scholar 

  • Bauer, C. A., & Brozoski, T. J. (2007). Gabapentin. Progress in Brain Research, 166, 287–301.

    PubMed  CAS  Google Scholar 

  • Bayar, N., Boke, B., Turan, E., & Belgin, E. (2001). Efficacy of amitriptyline in the treatment of subjective tinnitus. Journal of Otolaryngology, 30, 300–303.

    PubMed  CAS  Google Scholar 

  • Boly, M., Faymonville, M. E., Peigneux, P., Lambermont, B., Damas, P., Del, F. G., et al. (2004). Auditory processing in severely brain injured patients: Differences between the minimally conscious state and the persistent vegetative state. Archives of Neurology, 61, 233–238.

    PubMed  Google Scholar 

  • Burger, J., Frank, E., Kreuzer, P., Kleinjung, T., Vielsmeier, V., Landgrebe, M., et al. (2011). Transcranial magnetic stimulation for the treatment of tinnitus: Four-year follow-up in treatment responders. Brain Stimulation, 4, 222–227.

    PubMed  Google Scholar 

  • Busto, U., Sellers, E. M., Naranjo, C. A., Cappell, H., Sanchez-Craig, M., & Sykora, K. (1986). Withdrawal reaction after long-term therapeutic use of benzodiazepines. New England Journal of Medicine, 315, 854–859.

    PubMed  CAS  Google Scholar 

  • Busto, U., Fornazzari, L., & Naranjo, C. A. (1988). Protracted tinnitus after discontinuation of long-term therapeutic use of benzodiazepines. Journal of Clinical Psychopharmacology, 8, 359–362.

    PubMed  CAS  Google Scholar 

  • Chen, R., Classen, J., Gerloff, C., Celnik, P., Wassermann, E. M., Hallett, M., & Cohen, L. G. (1997). Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology, 48, 1398–1403.

    PubMed  CAS  Google Scholar 

  • Cheung, S. W., & Larson, P. S. (2010). Tinnitus modulation by deep brain stimulation in locus of caudate neurons (area LC). Neuroscience, 169, 1768–1778.

    PubMed  CAS  Google Scholar 

  • Crocetti, A., Forti, S., Ambrosetti, U., & Bo, L. D. (2009). Questionnaires to evaluate anxiety and depressive levels in tinnitus patients. Otolaryngology, Head and Neck Surgery, 140, 403–405.

    Google Scholar 

  • Darlington, C. L., & Smith, P. F. (2007). Drug treatments for tinnitus. Progress in Brain Research, 166, 249–262.

    PubMed  CAS  Google Scholar 

  • Dehaene, S., Changeux, J. P., Naccache, L., Sackur, J., & Sergent, C. (2006). Conscious, preconscious, and subliminal processing: A testable taxonomy. Trends in Cognitive Sciences, 10, 204–211.

    PubMed  Google Scholar 

  • Deliano, M., Scheich, H., & Ohl, F. W. (2009). Auditory cortical activity after intracortical microstimulation and its role for sensory processing and learning. Journal of Neuroscience, 29, 15898–15909.

    PubMed  CAS  Google Scholar 

  • Denk, D. M., Heinzl, H., Franz, P., & Ehrenberger, K. (1997). Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Oto-Laryngologica, 117, 825–830.

    CAS  Google Scholar 

  • De Ridder, D. (2010). Should rTMS for tinnitus be performed left-sided, ipsilaterally or contralaterally, and is it a treatment or merely investigational? European Journal of Neurology, 17, 891–892.

    PubMed  Google Scholar 

  • De Ridder, D., & Van de Heyning, P. (2007). The Darwinian plasticity hypothesis for tinnitus and pain. Progress in Brain Research, 166, 55–60.

    PubMed  Google Scholar 

  • De Ridder, D., De Mulder, G., Walsh, V., Muggleton, N., Sunaert, S., & Møller, A. (2004). Magnetic and electrical stimulation of the auditory cortex for intractable tinnitus. Case report. Journal of Neurosurgery, 100, 560–564.

    Google Scholar 

  • De Ridder, D., Verstraeten, E., Van der, K. K., De Mulder, G., Sunaert, S., Verlooy, J., et al. (2005). Transcranial magnetic stimulation for tinnitus: influence of tinnitus duration on stimulation parameter choice and maximal tinnitus suppression. Otology and Neurotology, 26, 616–619.

    Google Scholar 

  • De Ridder, D., De Mulder, G., Verstraeten, E., Van der Kelen, K., Sunaert, S., Smits, M., et al. (2006a). Primary and secondary auditory cortex stimulation for intractable tinnitus. Journal of Otorhinolaryngology and Related Specialities, 68, 48–54.

    Google Scholar 

  • De Ridder, D., Fransen, H., Francois, O., Sunaert, S., Kovacs, S., & Van de Heyning, P. (2006b). Amygdalohippocampal involvement in tinnitus and auditory memory. Acta Oto-Laryngologica Supplementum, 50–53.

    Google Scholar 

  • De Ridder, D., De Mulder, G., Menovsky, T., Sunaert, S., & Kovacs, S. (2007a). Electrical stimulation of auditory and somatosensory cortices for treatment of tinnitus and pain. Progress in Brain Research, 166, 377–388.

    PubMed  Google Scholar 

  • De Ridder, D., De Mulder, G., Verstraeten, E., Seidman, M., Elisevich, K., Sunaert, S., et al. (2007b). Auditory cortex stimulation for tinnitus. Acta Neurochirurgica Supplement, 97, 451–462.

    PubMed  Google Scholar 

  • De Ridder, D., van der Loo, E., Van der Kelen, K., Menovsky, T., Van de Heyning, P., & Møller, A. (2007c). Do tonic and burst TMS modulate the lemniscal and extralemniscal system differentially? International Journal of the Medical Sciences, 4, 242–246.

    Google Scholar 

  • De Ridder, D., van der Loo, E., Van der Kelen, K., Menovsky, T., Van de Heyning, P., & Møller, A. (2007d). Theta, alpha and beta burst transcranial magnetic stimulation: brain modulation in tinnitus. International Journal of the Medical Sciences, 4, 237–241.

    Google Scholar 

  • De Ridder, D., Menovsky, T., & Van de Heyning, P. (2008). Auditory cortex stimulation for tinnitus suppression. Otology and Neurotology, 29, 574–575.

    PubMed  Google Scholar 

  • De Ridder, D., Langguth, B., Plazier, M., Menovsky, T., & Van de Heyning, P. (2009). Auditory cortex stimulation for tinnitus. In S. Canavero (Ed.), Textbook of therapeutic cortical stimulation. New York: Nova Science Publishers.

    Google Scholar 

  • De Ridder, D., Vanneste, S., Adriaenssens, I., Lee, A. P., Plazier, M., Menovsky, T., et al. (2010a). Microvascular decompression for tinnitus: Significant improvement for tinnitus intensity without improvement for distress. A 4-year limit. Neurosurgery, 66, 656–660.

    Google Scholar 

  • De Ridder D., Vanneste, S., van der Loo E., Plazier, M., Menovsky, T., & Van de Heyning P. (2010b). Burst stimulation of the auditory cortex: A new form of neurostimulation for noise-like tinnitus suppression. Journal of Neurosurgery, 112, 1289–1294.

    PubMed  Google Scholar 

  • De Ridder, D., van der Loo, E., Vanneste, S., Gais, S., Plazier, M., Kovacs, S., et al. (2011a). Theta-gamma dysrhythmia and auditory phantom perception. Journal of Neurosurgery, 114, 912–921.

    PubMed  Google Scholar 

  • De Ridder, D., Vanneste, S., Kovacs, S., Sunaert, S., Menovsky, T., Van de Heyning, P., & Møller, A. (2011b). Transcranial magnetic stimulation and extradural electrodes implanted on secondary auditory cortex for tinnitus suppression. Journal of Neurosurgery, 114, 903–911.

    PubMed  Google Scholar 

  • Dobie, R. A. (1999). A review of randomized clinical trials in tinnitus. Laryngoscope, 109, 1202–1211.

    PubMed  CAS  Google Scholar 

  • Domeisen, H., Hotz, M. A., & Hausler, R. (1998). Caroverine in tinnitus treatment. Acta Oto-Laryngologica, 118, 606–608.

    PubMed  CAS  Google Scholar 

  • Donaldson, I. (1981). Tegretol: A double blind trial in tinnitus. Journal of Laryngology and Otology, 95, 947–951.

    PubMed  CAS  Google Scholar 

  • Engineer, N. D., Riley, J. R., Seale, J. D., Vrana, W. A., Shetake, J. A., Sudanagunta, S. P., et al. (2011). Reversing pathological neural activity using targeted plasticity. Nature, 470, 101–104.

    PubMed  Google Scholar 

  • Figueiredo, R. R., Langguth, B., Mello de, O. P., & Parecida de, A. A. (2008). Tinnitus treatment with memantine. Otolaryngology, Head and Neck Surgery, 138, 492–496.

    Google Scholar 

  • Folmer, R. L., Carroll, J. R., Rahim, A., Shi, Y., & Hal, M. W. (2006). Effects of repetitive transcranial magnetic stimulation (rTMS) on chronic tinnitus. Acta Oto-Laryngologica Supplementum, 556, 96–101.

    PubMed  Google Scholar 

  • Frank, G., Kleinjung, T., Landgrebe, M., Vielsmeier, V., Steffenhagen, C., Burger, J., et al. (2010). Left temporal low-frequency rTMS for the treatment of tinnitus: Clinical predictors of treatment outcome—a retrospective study. European Journal of Neurology, 17, 951–956.

    PubMed  CAS  Google Scholar 

  • Fregni, F., Marcondes, R., Boggio, P. S., Marcolin, M. A., Rigonatti, S. P., Sanchez, T. G., et al. (2006). Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation. European Journal of Neurology, 13, 996–1001.

    PubMed  CAS  Google Scholar 

  • Friedland, D. R., Gaggl, W., Runge-Samuelson, C., Ulmer, J. L., & Kopell, B. H. (2007). Feasibility of auditory cortical stimulation for the treatment of tinnitus. Otology and Neurotology, 28, 1005–1012.

    PubMed  Google Scholar 

  • Galaburda, A., & Sanides, F. (1980). Cytoarchitectonic organization of the human auditory cortex. Journal of Comparative Neurology, 190, 597–610.

    PubMed  CAS  Google Scholar 

  • Gananca, M. M., Caovilla, H. H., Gananca, F. F., Gananca, C. F., Munhoz, M. S., da Silva, M. L., & Serafini, F. (2002). Clonazepam in the pharmacological treatment of vertigo and tinnitus. International Tinnitus Journal, 8, 50–53.

    PubMed  CAS  Google Scholar 

  • Gil-Gouveia, R., & Goadsby, P. J. (2009). Neuropsychiatric side-effects of lidocaine: Examples from the treatment of headache and a review. Cephalalgia, 29, 496–508.

    PubMed  CAS  Google Scholar 

  • Goble, T. J., Møller, A. R., & Thompson, L. T. (2009). Acute high-intensity sound exposure alters responses of place cells in hippocampus. Hearing Research, 253, 52–59.

    PubMed  CAS  Google Scholar 

  • Goebel, G., & Hiller, W. (1994). The tinnitus questionnaire. A standard instrument for grading the degree of tinnitus: Results of a multicenter study with the tinnitus questionnaire. Hals-Nasen-Ohren Heilkunde, 42, 66–72.

    Google Scholar 

  • Guitton, M. J., Wang, J., & Puel, J. L. (2004). New pharmacological strategies to restore hearing and treat tinnitus. Acta Oto-Laryngologica, 4, 411–415.

    Google Scholar 

  • Hallett, M. (2000). Transcranial magnetic stimulation and the human brain. Nature, 406, 147–150.

    PubMed  CAS  Google Scholar 

  • Hoffman, R. E., & Cavus, I. (2002). Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. American Journal of Psychiatry, 159, 1093–1102.

    PubMed  Google Scholar 

  • Hoffman, R. E., Hawkins, K. A., Gueorguieva, R., Boutros, N. N., Rachid, F., Carroll, K., & Krystal, J. H. (2003). Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Archives of General Psychiatry, 60, 49–56.

    PubMed  Google Scholar 

  • Holley, M. C. (2005). Keynote review: The auditory system, hearing loss and potential targets for drug development. Drug Discovery Today, 10, 1269–1282.

    PubMed  CAS  Google Scholar 

  • Howland, R. H. (2010). Serendipity and psychopharmacology. Journal of Psychosocial Nursing and Mental Health Services, 48, 9–12.

    Google Scholar 

  • Hu, B., Senatorov, V., & Mooney, D. (1994). Lemniscal and non-lemniscal synaptic transmission in rat auditory thalamus. Journal of Physiology, 479 (Pt. 2), 217–231.

    PubMed  Google Scholar 

  • Huang, Y. Z., Edwards, M. J., Rounis, E., Bhatia, K. P., & Rothwell, J. C. (2005). Theta burst stimulation of the human motor cortex. Neuron, 45, 201–206.

    PubMed  CAS  Google Scholar 

  • Hulshof, J. H., & Vermeij, P. (1985). The value of carbamazepine in the treatment of tinnitus. Journal of Otorhinolaryngology and Related Specialties, 47, 262–266.

    CAS  Google Scholar 

  • Hurko, O., & Ryan, J. L. (2005). Translational research in central nervous system drug discovery. NeuroRx, 2, 671–682.

    PubMed  Google Scholar 

  • Iyer, M. B., Schleper, N., & Wassermann, E. M. (2003). Priming stimulation enhances the depressant effect of low-frequency repetitive transcranial magnetic stimulation. Journal of Neuroscience, 23, 10867–10872.

    PubMed  CAS  Google Scholar 

  • Jastreboff, P. J., Brennan, J. F., Coleman, J. K., & Sasaki, C. T. (1988). Phantom auditory sensation in rats: An animal model for tinnitus. Behavioural Neuroscience, 102, 811–822.

    CAS  Google Scholar 

  • Johnson, R. M., Brummett, R., & Schleuning, A. (1993). Use of alprazolam for relief of tinnitus: A double-blind study. Archives of Otolaryngology, Head and Neck Surgery, 119, 842–845.

    CAS  Google Scholar 

  • Katon, W., Sullivan, M., Russo, J., Dobie, R., & Sakai, C. (1993). Depressive symptoms and measures of disability: A prospective study. Journal of Affective Disorders, 27, 245–254.

    PubMed  CAS  Google Scholar 

  • Kay, N. J. (1981). Oral chemotherapy in tinnitus. British Journal of Audiology, 15, 123–124.

    PubMed  CAS  Google Scholar 

  • Khedr, E. M., Rothwell, J. C., Ahmed, M. A., & El-Atar, A. (2008). Effect of daily repetitive transcranial magnetic stimulation for treatment of tinnitus: Comparison of different stimulus frequencies. Journal of Neurology, Neurosurgery and Psychiatry, 79, 212–215.

    CAS  Google Scholar 

  • Khedr, E. M., Rothwell, J. C., & El-Atar, A. (2009). One-year follow up of patients with chronic tinnitus treated with left temporoparietal rTMS. European Journal of Neurology, 16, 404–408.

    PubMed  CAS  Google Scholar 

  • Khedr, E. M., bo-Elfetoh, N., Rothwell, J. C., El-Atar, A., Sayed, E., & Khalifa, H. (2010). Contralateral versus ipsilateral rTMS of temporoparietal cortex for the treatment of chronic unilateral tinnitus: Comparative study. European Journal of Neurology, 17, 976–983.

    Google Scholar 

  • Kleinjung, T., & Langguth, B. (2009). Strategies for enhancement of transcranial magnetic stimulation effects in tinnitus patients. International Tinnitus Journal, 15, 154–160.

    PubMed  Google Scholar 

  • Kleinjung, T., Eichhammer, P., Langguth, B., Jacob, P., Marienhagen, J., Hajak, G., et al. (2005). Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus. Otolaryngology, Head and Neck Surgery, 132, 566–569.

    Google Scholar 

  • Kleinjung, T., Steffens, T., Sand, P., Murthum, T., Hajak, G., Strutz, J., et al. (2007). Which tinnitus patients benefit from transcranial magnetic stimulation? Otolaryngology, Head and Neck Surgery, 137, 589–595.

    Google Scholar 

  • Kleinjung, T., Eichhammer, P., Landgrebe, M., Sand, P., Hajak, G., Steffens, T., et al.(2008). Combined temporal and prefrontal transcranial magnetic stimulation for tinnitus treatment: A pilot study. Otolaryngology, Head and Neck Surgery, 138, 497–501.

    Google Scholar 

  • Kleinjung, T., Steffens, T., Landgrebe, M., Vielsmeier, V., Frank, E., Hajak, G., et al. (2009). Levodopa does not enhance the effect of low-frequency repetitive transcranial magnetic stimulation in tinnitus treatment. Otolaryngology, Head and Neck Surgery, 140, 92–95.

    Google Scholar 

  • Kopke, R. D., Jackson, R. L., Coleman, J. K., Liu, J., Bielefeld, E. C., & Balough, B. J. (2007). NAC for noise: From the bench top to the clinic. Hearing Research, 226, 114–125.

    PubMed  Google Scholar 

  • Kramer, S., Dreisbach, L., Lockwood, J., Baldwin, K., Kopke, R., Scranton, S., & O’Leary, M. (2006). Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music. Journal of the American Academy of Audiology, 17, 265–278.

    PubMed  Google Scholar 

  • Kraus, K. S., Mitra, S., Jimenez, Z., Hinduja, S., Ding, D., Jiang, H., et al. (2010). Noise trauma impairs neurogenesis in the rat hippocampus. Neuroscience, 167, 1216–1226.

    PubMed  CAS  Google Scholar 

  • Landgrebe, M., Binder, H., Koller, M., Eberl, Y., Kleinjung, T., Eichhammer, P., et al. (2008). Design of a placebo-controlled, randomized study of the efficacy of repetitive transcranial magnetic stimulation for the treatment of chronic tinntius. BMC Psychiatry, 8, 23.

    PubMed  Google Scholar 

  • Landgrebe, M., Langguth, B., Rosengarth, K., Braun, S., Koch, A., Kleinjung, T., et al. (2009). Structural brain changes in tinnitus: Grey matter decrease in auditory and non-auditory brain areas. NeuroImage, 46, 213–218.

    PubMed  Google Scholar 

  • Landgrebe, M., Zeman, F., Koller, M., Eberl, Y., Mohr, M., Reiter, J., et al. (2010). The Tinnitus Research Initiative (TRI) database: A new approach for delineation of tinnitus subtypes and generation of predictors for treatment outcome. BMC Medical Information and Decision Making, 10, 42.

    Google Scholar 

  • Lang, N., Speck, S., Harms, J., Rothkegel, H., Paulus, W., & Sommer, M. (2007). Dopaminergic potentiation of rTMS-induced motor cortex inhibition. Biological Psychiatry, 63, 231–233.

    PubMed  Google Scholar 

  • Langguth, B., Zowe, M., Landgrebe, M., Sand, P., Kleinjung, T., Binder, H., et al. (2006). Transcranial magnetic stimulation for the treatment of tinnitus: A new coil positioning method and first results. Brain Topography, 18, 241–247.

    PubMed  Google Scholar 

  • Langguth, B., Kleinjung, T., Marienhagen, J., Binder, H., Sand, P. G., Hajak, G., & Eichhammer, P. (2007). Transcranial magnetic stimulation for the treatment of tinnitus: Effects on cortical excitability. BMC Neuroscience, 8, 45.

    PubMed  Google Scholar 

  • Langguth, B., Kleinjung, T., Frank, E., Landgrebe, M., Sand, P., Dvorakova, J., et al. (2008a). High-frequency priming stimulation does not enhance the effect of low-frequency rTMS in the treatment of tinnitus. Experimental Brain Research, 184, 587–591.

    Google Scholar 

  • Langguth, B., Kleinjung, T., Frank, E., Landgrebe, M., Sand, P., Dvorakova, J., et al. (2008b). High-frequency priming stimulation does not enhance the effect of low-frequency rTMS in the treatment of tinnitus. Experimental Brain Research, 184, 587–591.

    Google Scholar 

  • Langguth, B., Landgrebe, M., Hajak, G., & Kleinjung, T. (2008c). Re: Maintenance repetitive transcranial magnetic stimulation can inhibit the return of tinnitus. Laryngoscope, 118, 2264–2265.

    PubMed  Google Scholar 

  • Langguth, B., Kleinjung, T., Landgrebe, M., De, R. D., & Hajak, G. (2010). rTMS for the treatment of tinnitus: The role of neuronavigation for coil positioning. Neurophysiologie Clinique, 40, 45–58.

    PubMed  CAS  Google Scholar 

  • Langguth, B., Biesinger, E., Del Bo, L., De Ridder, D., Goodey, R., Herraiz, C., et al. (2011). Algorithm for the diagnostic and therapeutic management of tinnitus. In A. Møller, B. Langguth, D. De Ridder, & T. Kleinjung (Eds.), Textbook of tinnitus (1st ed., pp. 381–385). New York: Springer.

    Google Scholar 

  • Lanting, C. P., De, K. E., & Van, D. P. (2009). Neural activity underlying tinnitus generation: results from PET and fMRI. Hearing Research, 255, 1–13.

    PubMed  CAS  Google Scholar 

  • Laureys, S., Faymonville, M. E., Degueldre, C., Fiore, G. D., Damas, P., Lambermont, B., et al. (2000). Auditory processing in the vegetative state. Brain, 123 (Pt. 8), 1589–1601.

    PubMed  Google Scholar 

  • Leaver, A. M., Renier, L., Chevillet, M. A., Morgan, S., Kim, H. J., & Rauschecker, J. P. (2011). Dysregulation of limbic and auditory networks in tinnitus. Neuron, 69, 33–43.

    PubMed  CAS  Google Scholar 

  • Levine, R. A. (2006). Typewriter tinnitus: A carbamazepine-responsive syndrome related to auditory nerve vascular compression. Journal of Otorhinolaryngology and Related Specialities, 68, 43–46.

    CAS  Google Scholar 

  • Lim, D. J. (1986). Effects of noise and ototoxic drugs at the cellular level in the cochlea: A review. American Journal of Otolaryngology, 7, 73–99.

    PubMed  CAS  Google Scholar 

  • Litre, C. F., Theret, E., Tran, H., Leveque, M., Portefaix, C., Gierski, F., et al. (2009). Surgical treatment by electrical stimulation of the auditory cortex for intractable tinnitus. Brain Stimulation, 2, 132–137.

    PubMed  Google Scholar 

  • Litre, C. F., Giersky, F., Theret, E., Leveque, M., Peruzzi, P., & Rousseaux, P. (2010). [Feasibility of auditory cortical stimulation for the treatment of tinnitus. Three case reports]. Neurochirurgie, 56, 303–308.

    Google Scholar 

  • Llinas, R. R., Ribary, U., Jeanmonod, D., Kronberg, E., & Mitra, P. P. (1999). Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proceedings of the National Academy of Sciences of the USA, 96, 15222–15227.

    PubMed  CAS  Google Scholar 

  • Lobarinas, E., Sun, W., Cushing, R., & Salvi, R. (2004). A novel behavioral paradigm for assessing tinnitus using schedule-induced polydipsia avoidance conditioning (SIP-AC). Hearing Research, 190, 109–114.

    PubMed  Google Scholar 

  • Lobarinas, E., Sun, W., Stolzberg, D., Lu, J., & Salvi, R. (2008). Human brain imaging of tinnitus and animal models. Seminars in Hearing, 29, 333–349.

    PubMed  Google Scholar 

  • Londero, A., Langguth, B., De, R. D., Bonfils, P., & Lefaucheur, J. P. (2006a). Repetitive transcranial magnetic stimulation (rTMS): A new therapeutic approach in subjective tinnitus? Neurophysiologie Clinique, 36, 145–155.

    PubMed  CAS  Google Scholar 

  • Londero, A., Lefaucheur, J. P., Malinvaud, D., Brugieres, P., Peignard, P., Nguyen, J. P., et al. (2006b). [Magnetic stimulation of the auditory cortex for disabling tinnitus: preliminary results]. Presse Medicine, 35, 200–206.

    Google Scholar 

  • Lopez-Gonzalez, M. A., Moliner-Peiro, F., faro-Garcia, J., & Esteban-Ortega, F. (2007a). Sulpiride plus hydroxyzine decrease tinnitus perception. Auris Nasus Larynx, 34, 23–27.

    Google Scholar 

  • Lopez-Gonzalez, M. A., Santiago, A. M., & Esteban-Ortega, F. (2007b). Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway. Journal of Otolaryngology, 36, 213–219.

    PubMed  Google Scholar 

  • Lorenz, I., Muller, N., Schlee, W., Langguth, B., & Weisz, N. (2010). Short-term effects of single repetitive TMS sessions on auditory evoked activity in patients with chronic tinnitus. Journal of Neurophysiology, 104, 1497–1505.

    PubMed  Google Scholar 

  • Lynch, E. D., & Kil, J. (2005). Compounds for the prevention and treatment of noise-induced hearing loss. Drug Discovery Today, 10, 1291–1298.

    PubMed  CAS  Google Scholar 

  • Mansbach, A. L., & Freyens, P. (1983). [Tinnitus: Current data and treatment with sodium valproate]. Acta Otorhinolaryngologica Belgia, 37, 697–705.

    CAS  Google Scholar 

  • Mantovani, A., Lisanby, S. H., Pieraccini, F., Ulivelli, M., Castrogiovanni, P., & Rossi, S. (2006). Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette’s syndrome (TS). International Journal of Neuropsychopharmacology, 9, 95–100.

    PubMed  Google Scholar 

  • Marcondes, R. A., Sanchez, T. G., Kii, M. A., Ono, C. R., Buchpiguel, C. A., Langguth, B., & Marcolin, M. A. (2010). Repetitive transcranial magnetic stimulation improves tinnitus in normal hearing patients: A double-blind controlled, clinical and neuroimaging outcome study. European Journal of Neurology, 17, 38–44.

    PubMed  CAS  Google Scholar 

  • Mardini, M. K. (1987). Ear-clicking “tinnitus” responding to carbamazepine. New England Journal of Medicine, 317, 1542.

    PubMed  CAS  Google Scholar 

  • May, A., Hajak, G., Ganssbauer, S., Steffens, T., Langguth, B., Kleinjung, T., & Eichhammer, P. (2007). Structural brain alterations following 5 days of intervention: Dynamic aspects of neuroplasticity. Cerebral Cortex, 17, 205–210.

    PubMed  CAS  Google Scholar 

  • Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., et al. (2005). Deep brain stimulation for treatment-resistant depression. Neuron, 45, 651–660.

    PubMed  CAS  Google Scholar 

  • Meeus, O., Blaivie, C., Ost, J., De, R. D., & Van de, H. P. (2009). Influence of tonic and burst transcranial magnetic stimulation characteristics on acute inhibition of subjective tinnitus. Otology and Neurotology, 30, 697–703.

    PubMed  Google Scholar 

  • Meeus, O., De Ridder, D., Van de Heyning, P. (2011). Administration of the combination clonazepam-Deanxit as treatment for tinnitus. Otol Neurotol, 32(4):701–9.

    PubMed  CAS  Google Scholar 

  • Meikle, M. B., Stewart, B. J., Griest, S. E., Martin, W. H., Henry, J. A., Abrams, H. B., et al. (2007). Assessment of tinnitus: Measurement of treatment outcomes. Progress in Brain Research, 166, 511–521.

    PubMed  CAS  Google Scholar 

  • Melcher, J. R., Sigalovsky, I. S., Guinan, J. J., Jr., & Levine, R. A. (2000). Lateralized tinnitus studied with functional magnetic resonance imaging: Abnormal inferior colliculus activation. Journal of Neurophysiology, 83, 1058–1072.

    PubMed  CAS  Google Scholar 

  • Melding, P. S., & Goodey, R. J. (1979). The treatment of tinnitus with oral anticonvulsants. Journal of Laryngology and Otology, 93, 111–122.

    PubMed  CAS  Google Scholar 

  • Melding, P. S., Goodey, R. J., & Thorne, P. R. (1978). The use of intravenous lignocaine in the diagnosis and treatment of tinnitus. Journal of Laryngology and Otology, 92, 115–121.

    PubMed  CAS  Google Scholar 

  • Menkes, D. B., & Larson, P. M. (1998). Sodium valproate for tinnitus. Journal of Neurology, Neurosurgery and Psychiatry, 65, 803.

    CAS  Google Scholar 

  • Mennemeier, M., Chelette, K. C., Myhill, J., Taylor-Cooke, P., Bartel, T., Triggs, W., et al. (2008). Maintenance repetitive transcranial magnetic stimulation can inhibit the return of tinnitus. Laryngoscope, 118, 1228–1232.

    PubMed  Google Scholar 

  • Mico, J. A., Ardid, D., Berrocoso, E., & Eschalier, A. (2006). Antidepressants and pain. Trends of Pharmacological Sciences, 27, 348–354.

    CAS  Google Scholar 

  • Mihail, R. C., Crowley, J. M., Walden, B. E., Fishburne, J., Reinwall, J. E., & Zajtchuk, J. T. (1988). The tricyclic trimipramine in the treatment of subjective tinnitus. Annals of Otology, Rhinology and Laryngology, 97, 120–123.

    CAS  Google Scholar 

  • Moffat, G., Adjout, K., Gallego, S., Thai-Van, H., Collet, L., & Norena, A. J. (2009). Effects of hearing aid fitting on the perceptual characteristics of tinnitus. Hearing Research, 254, 82–91.

    PubMed  CAS  Google Scholar 

  • Møller, A. R. (2007). Tinnitus and pain. Progress in Brain Research, 166, 47–53.

    PubMed  Google Scholar 

  • Møller, M. B., Møller, A. R., Jannetta, P. J., & Jho, H. D. (1993). Vascular decompression surgery for severe tinnitus: Selection criteria and results. Laryngoscope, 103, 421–427.

    PubMed  Google Scholar 

  • Muehlmeier, G., Biesinger, E., & Maier, H. (2011). Safety of intratympanic injection of AM-101 in patients with acute inner ear tinnitus. Audiology and Neurotology, 16, 388–397.

    PubMed  CAS  Google Scholar 

  • Muhlau, M., Rauschecker, J. P., Oestreicher, E., Gaser, C., Rottinger, M., Wohlschlager, A. M., et al. (2006). Structural brain changes in tinnitus. Cerebral Cortex, 16, 1283–1288.

    PubMed  CAS  Google Scholar 

  • Muhlnickel, W., Elbert, T., Taub, E., & Flor, H. (1998). Reorganization of auditory cortex in tinnitus. Proceedings of the National Academy of Sciences of the USA, 95, 10340–10343.

    PubMed  CAS  Google Scholar 

  • Newman, C. W., & Sandridge, S. A. (2004). Tinnitus questionnaires. In J. B. Snow (Ed.), Tinnitus theory and management (pp. 237–254). London: BC Decker.

    Google Scholar 

  • Noreña, A., Micheyl, C., Chery-Croze, S., & Collet, L. (2002). Psychoacoustic characterization of the tinnitus spectrum: Implications for the underlying mechanisms of tinnitus. Audiology and Neurotology, 7, 358–369.

    PubMed  Google Scholar 

  • Okamoto, H., Stracke, H., Stoll, W., & Pantev, C. (2010). Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity. Proceedings of the National Academy of Sciences of the USA, 107, 1207–1210.

    PubMed  CAS  Google Scholar 

  • Pascual-Leone, A., Walsh, V., & Rothwell, J. (2000). Transcranial magnetic stimulation in cognitive neuroscience—virtual lesion, chronometry, and functional connectivity. Current Opinion in Neurobiology, 10, 232–237.

    PubMed  CAS  Google Scholar 

  • Perrot, X., Ryvlin, P., Isnard, J., Guenot, M., Catenoix, H., Fischer, C., et al. (2006). Evidence for corticofugal modulation of peripheral auditory activity in humans. Cerebral Cortex, 16, 941–948.

    PubMed  Google Scholar 

  • Piccirillo, J. F., Finnell, J., Vlahiotis, A., Chole, R. A., & Spitznagel, E., Jr. (2007). Relief of idiopathic subjective tinnitus: Is gabapentin effective? Archives of Otolaryngology, Head and Neck Surgery, 133, 390–397.

    Google Scholar 

  • Plazas, P. V., Savino, J., Kracun, S., Gomez-Casati, M. E., Katz, E., Parsons, C. G., et al. (2007). Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-d-aspartate receptors. European Journal of Pharmacology, 566, 11–19.

    PubMed  CAS  Google Scholar 

  • Plewnia, C., Bartels, M., & Gerloff, C. (2003). Transient suppression of tinnitus by transcranial magnetic stimulation. Annals of Neurology, 53, 263–266.

    PubMed  Google Scholar 

  • Plewnia, C., Reimold, M., Najib, A., Brehm, B., Reischl, G., Plontke, S. K., & Gerloff, C. (2007a). Dose-dependent attenuation of auditory phantom perception (tinnitus) by PET-guided repetitive transcranial magnetic stimulation. Human Brain Mapping, 28, 238–246.

    PubMed  Google Scholar 

  • Plewnia, C., Reimold, M., Najib, A., Reischl, G., Plontke, S. K., & Gerloff, C. (2007b). Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: A randomised, controlled pilot study. Journal of Neurology, Neurosurgery and Psychiatry, 78, 152–156.

    CAS  Google Scholar 

  • Poreisz, C., Paulus, W., Moser, T., & Lang, N. (2009). Does a single session of theta-burst transcranial magnetic stimulation of inferior temporal cortex affect tinnitus perception? BMC Neuroscience, 10, 54.

    PubMed  Google Scholar 

  • Puel, J. L., Ruel, J., Guitton, M., & Pujol, R. (2002). The inner hair cell afferent/efferent synapses revisited: A basis for new therapeutic strategies. Advances in Otorhinolaryngology, 59, 124–130.

    CAS  Google Scholar 

  • Ramirez, R. R., Kopell, B. H., Butson, C. R., Gaggl, W., Friedland, D. R., & Baillet, S. (2009). Neuromagnetic source imaging of abnormal spontaneous activity in tinnitus patient modulated by electrical cortical stimulation. Conference Proceedings—IEEE Engineering in Medicine and Biology Society, 2009, 1940–1944.

    Google Scholar 

  • Rauschecker, J. P., Leaver, A. M., & Muhlau, M. (2010). Tuning out the noise: limbic-auditory interactions in tinnitus. Neuron, 66, 819–826.

    PubMed  CAS  Google Scholar 

  • Reyes, S. A., Salvi, R. J., Burkard, R. F., Coad, M. L., Wack, D. S., Galantowicz, P. J., & Lockwood, A. H. (2002). Brain imaging of the effects of lidocaine on tinnitus. Hearing Research, 171, 43–50.

    PubMed  CAS  Google Scholar 

  • Rivier, F., & Clarke, S. (1997). Cytochrome oxidase, acetylcholinesterase, and NADPH-diaphorase staining in human supratemporal and insular cortex: Evidence for multiple auditory areas. NeuroImage, 6, 288–304.

    PubMed  CAS  Google Scholar 

  • Robinson, S. K., Viirre, E. S., & Stein, M. B. (2007). Antidepressant therapy in tinnitus. Hearing Research, 226, 221–231.

    PubMed  CAS  Google Scholar 

  • Rossi, S., De, C. A., Ulivelli, M., Bartalini, S., Falzarano, V., Filippone, G., & Passero, S. (2007). Effects of repetitive transcranial magnetic stimulation on chronic tinnitus: A randomised, cross over, double blind, placebo-controlled study. Journal of Neurology, Neurosurgery and Psychiatry, 78, 857–863.

    Google Scholar 

  • Ryu, H., Yamamoto, S., Sugiyama, K., Uemura, K., & Nozue, M. (1998). Neurovascular decompression of the eighth cranial nerve in patients with hemifacial spasm and incidental tinnitus: An alternative way to study tinnitus. Journal of Neurosurgery, 88, 232–236.

    PubMed  CAS  Google Scholar 

  • Schaette, R., Konig, O., Hornig, D., Gross, M., & Kempter, R. (2010). Acoustic stimulation treatments against tinnitus could be most effective when tinnitus pitch is within the stimulated frequency range. Hearing Research, 269, 95–101.

    PubMed  Google Scholar 

  • Schlee, W., Dohrmann, K., Hartmann, T., Lorenz, N., Mülller, N., Elbert, T., & Weisz, N. (2008a). Assessment and modification of the tinnitus-related cortical network. Seminars in Hearing, 29, 270–287.

    Google Scholar 

  • Schlee, W., Weisz, N., Bertrand, O., Hartmann, T., & Elbert, T. (2008b). Using auditory steady state responses to outline the functional connectivity in the tinnitus brain. PLoS ONE, 3, e3720.

    PubMed  Google Scholar 

  • Schlee, W., Hartmann, T., Langguth B, & Weisz, N. (2009a). Abnormal resting-state cortical coupling in chronic tinnitus. BMC Neuroscience, 10, 11.

    PubMed  Google Scholar 

  • Schlee, W., Mueller, N., Hartmann, T., Keil, J., Lorenz, I., & Weisz, N. (2009b). Mapping cortical hubs in tinnitus. BMC Biology, 7, 80.

    PubMed  Google Scholar 

  • Seidman, M. D., Ridder, D. D., Elisevich, K., Bowyer, S. M., Darrat, I., Dria, J., et al. (2008). Direct electrical stimulation of Heschl’s gyrus for tinnitus treatment. Laryngoscope, 118, 491–500.

    PubMed  CAS  Google Scholar 

  • Shea, J. J., & Harell, M. (1978). Management of tinnitus aurium with lidocaine and carbamazepine. Laryngoscope, 88, 1477–1484.

    PubMed  CAS  Google Scholar 

  • Shi, Y., Burchiel, K. J., Anderson, V. C., & Martin, W. H. (2009). Deep brain stimulation effects in patients with tinnitus. Otolaryngology, Head and Neck Surgery, 141, 285–287.

    Google Scholar 

  • Siebner, H. R., Tormos, J. M., Ceballos-Baumann, A. O., Auer, C., Catala, M. D., Conrad, B., & Pascual-Leone, A. (1999). Low-frequency repetitive transcranial magnetic stimulation of the motor cortex in writer’s cramp. Neurology, 52, 529–537.

    PubMed  CAS  Google Scholar 

  • Siebner, H. R., Filipovic, S. R., Rowe, J. B., Cordivari, C., Gerschlager, W., Rothwell, J. C., et al. (2003). Patients with focal arm dystonia have increased sensitivity to slow-frequency repetitive TMS of the dorsal premotor cortex. Brain 126, 2710–2725.

    PubMed  Google Scholar 

  • Simpson, J. J., Gilbert, A. M., Weiner, G. M., & Davies, W. E. (1999). The assessment of lamotrigine, an antiepileptic drug, in the treatment of tinnitus. American Journal of Otology, 20, 627–631.

    PubMed  CAS  Google Scholar 

  • Slotema, C. W., Blom, J. D., Hoek, H. W., & Sommer, I. E. (2010). Should we expand the toolbox of psychiatric treatment methods to include repetitive transcranial magnetic stimulation (rTMS)? A meta-analysis of the efficacy of rTMS in psychiatric disorders. Journal of Clinical Psychiatry, 71, 873–884.

    PubMed  Google Scholar 

  • Smith, J. A., Mennemeier, M., Bartel, T., Chelette, K. C., Kimbrell, T., Triggs, W., & Dornhoffer, J. L. (2007). Repetitive transcranial magnetic stimulation for tinnitus: A pilot study. Laryngoscope, 117, 529–534.

    PubMed  Google Scholar 

  • Smits, M., Kovacs, S., De, R. D., Peeters, R. R., Van, H. P., & Sunaert, S. (2007). Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus. Neuroradiology, 49, 669–679.

    PubMed  Google Scholar 

  • Suckfuell, M., Althaus, M., Ellers-Lenz, B., Gebauer, A., Goertelmeyer, R., Jastreboff, P. J., et al. (2011). A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus. BMC Ear Nose and Throat Disorders, 11, 1.

    CAS  Google Scholar 

  • Suga, N., Gao, E., Zhang, Y., Ma, X., & Olsen, J. F. (2000). The corticofugal system for hearing: recent progress. Proceedings of the National Academy of Sciences of the USA, 97, 11807–11814.

    PubMed  CAS  Google Scholar 

  • Sullivan, M., Katon, W., Russo, J., Dobie, R., & Sakai, C. (1993). A randomized trial of nortriptyline for severe chronic tinnitus: Effects on depression, disability, and tinnitus symptoms. Archives of Internal Medicine, 153, 2251–2259.

    PubMed  CAS  Google Scholar 

  • Sullivan, M. D., Dobie, R. A., Sakai, C. S., & Katon, W. J. (1989). Treatment of depressed tinnitus patients with nortriptyline. Annals of Otology, Rhinology and Laryngology, 98, 867–872.

    CAS  Google Scholar 

  • Talavage, T. M., Ledden, P. J., Benson, R. R., Rosen, B. R., & Melcher, J. R. (2000). Frequency-dependent responses exhibited by multiple regions in human auditory cortex. Hearing Research, 150, 225–244.

    PubMed  CAS  Google Scholar 

  • Talavage, T. M., Sereno, M. I., Melcher, J. R., Ledden, P. J., Rosen, B. R., & Dale, A. M. (2004). Tonotopic organization in human auditory cortex revealed by progressions of frequency sensitivity. Journal of Neurophysiology, 91, 1282–1296.

    PubMed  Google Scholar 

  • Tandon, R., Grunhaus, L., & Greden, J. F. (1987). Imipramine and tinnitus. Journal of Clinical Psychiatry, 48, 109–111.

    PubMed  CAS  Google Scholar 

  • Trellakis, S., Lautermann, J., & Lehnerdt, G. (2007). Lidocaine: Neurobiological targets and effects on the auditory system. Progress in Brain Research, 166, 303–322.

    PubMed  CAS  Google Scholar 

  • Turner, J. G. (2007). Behavioral measures of tinnitus in laboratory animals. Progress in Brain Research, 166, 147–156.

    PubMed  Google Scholar 

  • Tyler, R., Coelho, C., Tao, P., Ji, H., Noble, W., Gehringer, A., & Gogel, S. (2008). Identifying tinnitus subgroups with cluster analysis. American Journal of Audiology, 17, S176–S184.

    PubMed  Google Scholar 

  • Van de Heyning, P., Vermeire, K., Diebl, M., Nopp, P., Anderson, I., & De, R. D. (2008). Incapacitating unilateral tinnitus in single-sided deafness treated by cochlear implantation. Annals of Otology, Rhinology and Laryngology, 117, 645–652.

    Google Scholar 

  • van der Loo, E., Gais, S., Congedo, M., Vanneste, S., Plazier, M., Menovsky, T., et al. (2009). Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex. PLoS ONE, 4, e7396.

    PubMed  Google Scholar 

  • Vanneste, S., Plazier, M., der Loo, E., de Heyning, P. V., Congedo, M., & De Ridder, D. (2010a). The neural correlates of tinnitus-related distress. NeuroImage, 52, 470–480.

    PubMed  Google Scholar 

  • Vanneste, S., Plazier, M., Ost, J., van der Loo, E., Van de Heyning, P., & De Ridder, D. (2010b). Bilateral dorsolateral prefrontal cortex modulation for tinnitus by transcranial direct current stimulation: A preliminary clinical study. Experimental Brain Research, 202, 779–785.

    Google Scholar 

  • Vanneste, S., Plazier, M., van der Loo, E., Van de Heyning, P., & De Ridder, D. (2010c). The difference between uni- and bilateral auditory phantom percept. Clinical Neurophysiology, 122, 578–587.

    PubMed  Google Scholar 

  • Vanneste, S., Plazier, M., van der Loo, E., Van de Heyning, P., & De Ridder, D. (2010d). The differences in brain activity between narrow band noise and pure tone tinnitus. PLoS ONE, 5, e13618.

    PubMed  Google Scholar 

  • Vanneste, S., Langguth, B., & De Ridder, D. (2011). Do tDCS and TMS influence tinnitus via a direct cortical and indirect somatosensory modulating effect? A combined TMS-tDCSand TENS study. Brain Stimulation, 4, 242–252.

    PubMed  Google Scholar 

  • Vio, M. M., & Holme, R. H. (2005). Hearing loss and tinnitus: 250 million people and a US$10 billion potential market. Drug Discovery Today, 10, 1263–1265.

    PubMed  Google Scholar 

  • Wang, H., Wang, X., & Scheich, H. (1996). LTD and LTP induced by transcranial magnetic stimulation in auditory cortex. NeuroReport, 7, 521–525.

    PubMed  CAS  Google Scholar 

  • Weisz, N., Wienbruch, C., Dohrmann, K., & Elbert, T. (2005). Neuromagnetic indicators of auditory cortical reorganization of tinnitus. Brain, 128, 2722–2731.

    PubMed  Google Scholar 

  • Weisz, N., Dohrmann, K., & Elbert, T. (2007a). The relevance of spontaneous activity for the coding of the tinnitus sensation. Progress in Brain Research, 166, 61–70.

    PubMed  Google Scholar 

  • Weisz, N., Muller, S., Schlee, W., Dohrmann, K., Hartmann, T., & Elbert, T. (2007b). The neural code of auditory phantom perception. Journal of Neuroscience, 27, 1479–1484.

    PubMed  CAS  Google Scholar 

  • Witsell, D. L., Hannley, M. T., Stinnet, S., & Tucci, D. L. (2007). Treatment of tinnitus with gabapentin: A pilot study. Otology and Neurotology, 28, 11–15.

    PubMed  Google Scholar 

  • Zhang, J., Zhang, Y., & Zhang, X. (2011). Auditory cortex electrical stimulation suppresses tinnitus in rats. Journal of the Association of Research in Otolaryngology,12, 185–201.

    Google Scholar 

  • Zoger, S., Svedlund, J., & Holgers, K. M. (2006). The effects of sertraline on severe tinnitus suffering—a randomized, double-blind, placebo-controlled study. Journal of Clinical Psychopharmacology, 26, 32–39.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Interdisciplinary Tinnitus Clinic, Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93053, Regensburg, Germany

    Berthold Langguth

  2. TRI, BRAI2N & Department of Neurosurgery, University Hospital Antwerp, Wilrijkstraat 10, 2650, Edegem, Belgium

    Dirk De Ridder

  3. Interdisciplinary Tinnitus Clinic, Department of Otolaryngology, University of Regensburg, Universitaetsstraße 84, 93053, Regensburg, Germany

    Tobias Kleinjung

  4. Department of Otolaryngology, University of Zürich, Frauenklinikstr. 24, 8091, Zürich, Switzerland

    Tobias Kleinjung

  5. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

    Ana Belén Elgoyhen

  6. Department of Pharmacology, University of Buenos Aires, School of Medicine, Vuelta de Obligado 2490, 1428, Buenos Aires, Argentina

    Ana Belén Elgoyhen

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  1. Berthold Langguth
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Correspondence to Berthold Langguth .

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  1. Dept. Psychology, University of Calgary, University Drive NW., 2500, Calgary, T2N 1N4, Alberta, Canada

    Jos J. Eggermont

  2. Dept. Otolaryngology - Head &, Neck Surgery, University of California, Irvine, Irvine, 92697, California, USA

    Fan-Gang Zeng

  3. , Department of Biology, University of Maryland, 2225 Bio-Psych, College Park, 20742-4415, Maryland, USA

    Arthur N. Popper

  4. Marine Biological Laboratory, 7 MBL Street, Woods Hole, 02543, Massachusetts, USA

    Richard R. Fay

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Langguth, B., De Ridder, D., Kleinjung, T., Elgoyhen, A.B. (2012). Treatment: Pharmacological, Repetitive Transcranial Magnetic Stimulation, Epidural Stimulation, and Deep Brain Stimulation. In: Eggermont, J., Zeng, FG., Popper, A., Fay, R. (eds) Tinnitus. Springer Handbook of Auditory Research, vol 44. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3728-4_11

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