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Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins

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Mitochondrial Oxidative Phosphorylation

Part of the book series: Advances in Experimental Medicine and Biology ((volume 748))

Abstract

Mitochondrial uncoupling proteins are members of the SLC25 family of solute carriers. Models of mitochondrial transporter function predict that uncoupling proteins are solute carriers. Evidence in the literature suggests that uncoupling proteins can transport protons, fatty acid anions, chloride anions, and recently the dicarboxylate succinate. Studies have also demonstrated that UCPs can be covalently modified and in some instances this covalent modification is needed to affect uncoupling function. The current evidence from functional analyses of mammalian uncoupling proteins is summarized in this chapter.

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Acknowledgement

R.K. Porter would like to thank Bernhard Kadenbach for the invitation to write this chapter.

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  1. School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland

    Richard K. Porter

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Correspondence to Richard K. Porter .

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  1. Philipps-Universitaet Marburg, Marburg, 35032, Germany

    Bernhard Kadenbach

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Porter, R.K. (2012). Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins. In: Kadenbach, B. (eds) Mitochondrial Oxidative Phosphorylation. Advances in Experimental Medicine and Biology, vol 748. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3573-0_7

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