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The Robustness Continuum

  • Sasha F. Levy
  • Mark L. Siegal
Part of the Advances in Experimental Medicine and Biology book series (volume 751)

Abstract

Organisms are subject to random changes in their external environments, as well as in their internal components. A central goal of evolutionary systems biology is to understand how living systems cope with—and in some cases exploit—this variation. Many cellular and developmental processes operate with high fidelity to produce stereotyped, irreversible outcomes despite environmental and genetic perturbation. These processes are said to be robust or insensitive to variation. Robustness can lead to single, invariant phenotypes, or it can take the form of phenotypic plasticity, in which different environmental conditions reproducibly induce distinct phenotypes. Some organisms cope with environmental variation not with robust responses but with stochastic, reversible fate decisions. In those organisms, lower robustness yields heterogeneity among individuals, which in turn serves as a bet-hedging mechanism for the population. Considering high-fidelity and bet-hedging processes together—as a robustness continuum—provides a unifying framework for analyzing and conceptualizing variation in complex evolving systems. This framework can be applied to understanding the architectures and dynamics of the regulatory networks that underlie fate decisions in microbes, plants, animals, and cancer cells.

Keywords

Attractor State Inducer Concentration Phenotypic State Persister Cell Uninduced Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of GeneticsStanford University Medical SchoolStanfordUSA
  2. 2.Center for Genomics and Systems Biology, Department of BiologyNew York UniversityNew YorkUSA

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