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Advances in Yersinia Research pp 325–334Cite as

OmpR, a Central Integrator of Several Cellular Responses in Yersinia enterocolitica

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 954)

Abstract

The molecular responses of bacteria to signals from the external environment are complex, but two-component transduction systems are known to play an important role. Here, we summarize the findings of our studies to elucidate the function of the EnvZ/OmpR system in the control of a wide range of physiological processes in Yersinia enterocolitica (bio-serotype 2/O9) that are involved in environmental and host-associated stress adaptation and virulence. Our results provide evidence that OmpR participates in the adaptation of Y. enterocolitica to high osmolarity, oxidative, and low pH stresses. Moreover, they show that the OmpR response regulator both positively and negatively modulates the expression of multiple genes implicated in the control of physiological processes, such as outer membrane permeability, motility, adhesion and invasion abilities, as well as biofilm formation, and this regulation may be fine-tuned in response to changing environmental conditions.

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Acknowledgments

This work was supported by the Polish Ministry of Science and Higher Education (grant N303 009 32/0537).

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Authors and Affiliations

  1. Department of Applied Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland

    Katarzyna Brzostek, Karolina Skorek & Adrianna Raczkowska

Authors
  1. Katarzyna Brzostek
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  2. Karolina Skorek
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  3. Adrianna Raczkowska
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Correspondence to Katarzyna Brzostek .

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Editors and Affiliations

  1. , Centro de Pesquisa Aggeu Magalhães, Campus da UFPE, Recife, 50670, Brazil

    Alzira Maria Paiva de Almeida

  2. , Centro de Pesquisa Aggeu Magalhães, Campus da UFPE, Recife, 50670-420, Brazil

    Nilma Cintra Leal

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Brzostek, K., Skorek, K., Raczkowska, A. (2012). OmpR, a Central Integrator of Several Cellular Responses in Yersinia enterocolitica . In: de Almeida, A., Leal, N. (eds) Advances in Yersinia Research. Advances in Experimental Medicine and Biology, vol 954. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3561-7_40

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