Abstract
Autoagglutination (AA) is a virulence-associated trait typical of various pathogenic bacteria, including Yersinia pestis. In this study, we show that AA in Y. pestis is a complex phenomenon determined by the HCP-like protein of T6SS which is encoded by ypo0502 and by the siderophore Yersiniachelin (Ych) which is encoded by the ysu locus. Down-regulation of YPO0502 expression by antisense RNA abrogates AA in G8786 (Hms+) and EV76 (Hms−) Y. pestis strains. The deletion of Ych biosynthetic genes ypo1530-1532 in EV76 though does not abolish AA results in its noticeable depression.
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Podladchikova, O., Rykova, V., Antonenka, U., Rakin, A. (2012). Yersinia pestis Autoagglutination Is Mediated by HCP-Like Protein and Siderophore Yersiniachelin (Ych). In: de Almeida, A., Leal, N. (eds) Advances in Yersinia Research. Advances in Experimental Medicine and Biology, vol 954. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3561-7_36
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DOI: https://doi.org/10.1007/978-1-4614-3561-7_36
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