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Sleep Apnea and Obesity

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Sleep Loss and Obesity

Abstract

Obesity and obstructive sleep apnea (OSA) are two extremely common and tightly linked disorders. Obesity, particularly in a pattern that increases fat deposition in the neck and upper body, has strong effects on OSA pathogenesis by narrowing the upper airway and increasing airway collapsibility. The effect of obesity on OSA risk is strongest in younger and male populations. In addition, growing evidence suggests OSA may have effects through intermittent hypoxia, sleep fragmentation or other mechanisms, on adipose tissue or pathways that regulate weight homeostasis. Finally, a number of genetic, perinatal, and environmental factors may independently impact risk of both obesity and OSA. Given their high prevalence and frequent coexistence, as well as the shared complications induced by these two conditions particularly in terms of cardiovascular and metabolic diseases, treatment strategies at both an individual and population level should focus on evaluating and treating both conditions.

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  1. Division of Pulmonary, Critical Care and Sleep Medicine, MetroHealth Medical Center, Case Western Reserve University, 2500 MetroHealth Drive, Room BG3-38, Cleveland, OH, 44109, USA

    Vidya Krishnan MD, MHS

  2. Division of Sleep Medicine, Brigham and Women’s Hospital, 221 Longwood Avenue, Room 225-C, Boston, MA, 02115, USA

    Sanjay R. Patel MD, MS

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  1. Vidya Krishnan MD, MHS
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  2. Sanjay R. Patel MD, MS
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Correspondence to Sanjay R. Patel MD, MS .

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Editors and Affiliations

  1. , Division of Sleep Medicine, Harvard Medical School, 1400 VFW Parkway, West Roxbury, 02132, USA

    Priyattam Shiromani

  2. , Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave., New Haven, 06519, USA

    Tamas Horvath

  3. , Department of Medicine, Harvard Medical School, Brigham and Wome, 221 Longwood Ave., Boston, 02115, USA

    Susan Redline

  4. , Department of Medicine, The University of Chicago, 5841 S. Maryland Avenue, Chicago, 60637, USA

    Eve Van Cauter

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© 2012 Springer Science+Business Media, LLC

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Krishnan, V., Patel, S.R. (2012). Sleep Apnea and Obesity. In: Shiromani, P., Horvath, T., Redline, S., Van Cauter, E. (eds) Sleep Loss and Obesity. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3492-4_9

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  • DOI: https://doi.org/10.1007/978-1-4614-3492-4_9

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  • Online ISBN: 978-1-4614-3492-4

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