Dogs as Cancer Detectors

  • Dawn A. Marcus
Chapter

Key Chapter Points

Screening for cancer by detecting biomarkers of early disease is an important aspect of cancer care. Humans have tapped into dogs’ abilities to detect and identify scents for hunting and tracking, search and rescue, and police and military assistance.

  • Dogs have superior ability to detect and recognize weak concentrations of odors.

  • Nasal anatomy and genome features may help explain canine sniffing abilities.

  • Dogs have been reported to successfully identify several types of cancer.

  • Laboratory analysis of volatile gases can be used to differentiate cancer from noncancer cells, supporting an ability to identify some cancers based on smell analysis.

Keywords

Alert Gas chromatography Mass spectroscopy Olfactory Smellprints Volatile organic compounds 

References

  1. 1.
    Tacher S, Quignon P, Rimbault M, et al. Olfactory receptor sequence polymorphism within and between breeds of dogs. J Hered. 2005;96:812–6.PubMedCrossRefGoogle Scholar
  2. 2.
    Lesniak A, Walczak M, Jezierski T, et al. Canine olfactory receptor gene polymorphism and its relation to odor detection performance by sniffer dogs. J Hered. 2008;99:851–27.CrossRefGoogle Scholar
  3. 3.
    Robin S, Tacher S, Rimbault M, et al. Genetic diversity of canine olfactory receptors. BMC Genomics. 2009;10:21.PubMedCrossRefGoogle Scholar
  4. 4.
    Balseiro SC, Correia HR. Is olfactory detection of human cancer by dogs based on major histocompatibility complex-dependent odour components?—A possible cure and a precocious diagnosis of cancer. Med Hypotheses. 2006;66:270–2.PubMedCrossRefGoogle Scholar
  5. 5.
    Lit L, Schweitzer JB, Oberbauer AM. Handler beliefs affect scent detection dog outcomes. Anim Cogn. 2011;14:387–94.PubMedCrossRefGoogle Scholar
  6. 6.
    Wells DL, Lawson SW, Siriwardena AN. Canine responses to hypoglycemia in patients with type 1 diabetes. J Altern Complement Med. 2008;14:1235–41.PubMedCrossRefGoogle Scholar
  7. 7.
    Welsh JS, Barton D, Ahuja H. A case of breast cancer detected by a pet dog. Community Oncol. 2005;2:324–6.CrossRefGoogle Scholar
  8. 8.
    Williams H, Pembroke A. Sniffer dogs in the melanoma clinic? Lancet. 1989;1:734.PubMedCrossRefGoogle Scholar
  9. 9.
    Church H, Williams H. Another sniffer dog in the clinic? Lancet. 2001;358:930.PubMedCrossRefGoogle Scholar
  10. 10.
    Pickel D, Manucy GP, Walker DB, Hall SB, Walker JC. Evidence for canine olfactory detection of melanoma. Appl Anim Behav Sci. 2004;89:107–16.CrossRefGoogle Scholar
  11. 11.
    Alabama A&M and Auburn Universities. The dog’s sense of smell. Available at www.aces.edu/pubs/docs/U/UNP-0066/UNP-0066.pdf. Accessed September 2011.
  12. 12.
    Døving KB, Trotier D. Structure and function of the vomeronasal organ. J Exp Biol. 1998;201:2913–25.PubMedGoogle Scholar
  13. 13.
    Lippi G, Cervellin G. Canine olfactory detection of cancer versus laboratory testing: myth or opportunity? Clin Chem Lab Med, in press.Google Scholar
  14. 14.
    Kavoi B, Makanya A, Hassanali J, Carlsson HE, Kiana S. Comparative functional structure of the olfactory mucosa in the domestic dog and sheep. Ann Anat. 2010;192:329–37.PubMedCrossRefGoogle Scholar
  15. 15.
    Issel-Tarver L, Rine J. The evolution of mammalian olfactory receptor genes. Genetics. 1997;145:185–95.PubMedGoogle Scholar
  16. 16.
    Olender T, Fuchs T, Linhart C, et al. The canine olfactory subgenome. Genomics. 2004;83:361–72.PubMedCrossRefGoogle Scholar
  17. 17.
    Göth A, McLean IG, Trevelyan J. How do dogs detect landmines? A summary of research results. In: McLean IG, editor. Mine detection dogs: training, operations and odour detection. Geneva: GICHD; 2003.Google Scholar
  18. 18.
    Pavlou AK, Turner AP. Sniffing out truth: clinical diagnosis using the electronic nose. Clin Chem Lab Med. 2000;38:99–112.PubMedCrossRefGoogle Scholar
  19. 19.
    Turner AP, Magan N. Electronic noses and disease diagnostics. Nat Rev Microbiol. 2004;2:161–6.PubMedCrossRefGoogle Scholar
  20. 20.
    Kodogiannis VS, Lygouras JN, Tarczynski A, Chowdrey HS. Artificial odor discrimination system using electronic nose and neural networks for the identification of urinary tract infection. IEEE Trans Info Technol Biomed. 2008;12:707–13.CrossRefGoogle Scholar
  21. 21.
    Charaklias N, Raja H, Humphreys ML, Magan N, Kendall CA. The future of early disease detection? Applications of electronic nose technology in otolaryngology. J Laryngol Otol. 2010;124:823–7.PubMedCrossRefGoogle Scholar
  22. 22.
    Popov TA. Human exhaled breath analysis. Ann Allergy Asthma Immunol. 2011;106:451–6.PubMedCrossRefGoogle Scholar
  23. 23.
    Chen X, Xu F, Wang Y, et al. A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis. Cancer. 2007;110:835–44.PubMedCrossRefGoogle Scholar
  24. 24.
    Gordon SM, Szidon JP, Krotoszynski B, Gibbons RD, O’Neill HJ. Volatile organic compounds in exhales air from patients with lung cancer. Clin Chem. 1985;31:1278–82.PubMedGoogle Scholar
  25. 25.
    Phillips M, Gleeson K, Hughes JM, et al. Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet. 1999;355:1930–3.CrossRefGoogle Scholar
  26. 26.
    Phillips M, Cataneo R, Cummin A, et al. Detection of lung cancer with volatile markers in the breath. Chest. 2003;123:2115–23.PubMedCrossRefGoogle Scholar
  27. 27.
    Phillips M, Altorki N, Austin JM, et al. Detection of lung cancer using weighted digital analysis of breath biomarkers. Clin Chem Acta. 2008;393:76–84.CrossRefGoogle Scholar
  28. 28.
    Chan HP, Lewis C, Thomas PS. Exhaled breath analysis: novel approach for early detection of lung cancer. Lung Cancer. 2009;63:164–8.PubMedCrossRefGoogle Scholar
  29. 29.
    Horváth I, Lázár Z, Gyulai N, Kollai M, Losonczy G. Exhaled biomarkers in lung cancer. Eur Respir J. 2009;34:261–75.PubMedCrossRefGoogle Scholar
  30. 30.
    Bajtarevic A, Ager C, Pienz M, et al. Noninvasive detection of lung cancer by analysis of exhaled breath. BMC Cancer. 2009;9:348.PubMedCrossRefGoogle Scholar
  31. 31.
    Machado RF, Laskowski D, Deffenderfer O, et al. Detection of lung cancer by sensor array analyses of exhaled breath. Am J Respir Crit Care Med. 2005;171:1286–91.PubMedCrossRefGoogle Scholar
  32. 32.
    Dragonieri S, Annerna JT, Schot R, et al. An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD. Lung Cancer. 2009;64:166–70.PubMedCrossRefGoogle Scholar
  33. 33.
    D’Amico A, Pennazza G, Santonico M, et al. An investigation on electronic nose diagnosis of lung cancer. Lung Cancer. 2010;68:170–6.PubMedCrossRefGoogle Scholar
  34. 34.
    Kischkel S, Miekisch W, Sawacki A, et al. Breath biomarkers for lung cancer detection and assessment of smoking related effects—confounding variables, influence of normalization and statistical algorithms. Clin Chim Acta. 2010;411:1637–44.PubMedCrossRefGoogle Scholar
  35. 35.
    Phillips M, Cataneo RN, Ditkoff BA, et al. Prediction of breast cancer using volatile biomarkers in the breath. Breast Cancer Res Treat. 2006;99:19–21.PubMedCrossRefGoogle Scholar
  36. 36.
    Phillips M, Cataneo RN, Saunders C, et al. Volatile biomarkers in the breath of women with breast cancer. J Breath Res. 2010;4:026003.PubMedCrossRefGoogle Scholar
  37. 37.
    D’Amico A, Bono R, Pennazza G, et al. Identification of melanoma with a gas sensor array. Skin Res Technol. 2008;14:226–36.PubMedCrossRefGoogle Scholar
  38. 38.
    Kateb B, Ryan MA, Homer ML, et al. Sniffing out cancer using the JPL electronic nose: a pilot study of a novel approach to detection and differentiation of brain cancer. Neuroimage. 2009;47 suppl 2:T5–9.PubMedCrossRefGoogle Scholar
  39. 39.
    McCullouch M, Jezierski T, Broffman M, et al. Diagnostic accuracy of canine scent detection in early- and late-stage lung and breast cancers. Integr Cancer Ther. 2006;5:30–9.CrossRefGoogle Scholar
  40. 40.
    Willis CM, Church SM, Guest CM, et al. Olfactory detection of human bladder cancer by dogs: proof of principle study. BMJ. 2004;329:712.PubMedCrossRefGoogle Scholar
  41. 41.
    Gordon RT, Schatz CB, Myers LJ, et al. The use of canines in the detection of human cancers. J Altern Complement Med. 2008;14:61–7.PubMedCrossRefGoogle Scholar
  42. 42.
    Cornu J, Cancel-Tassin G, Ondet V, Girardet C, Cussenot O. Olfactory detection of prostate cancer by dogs sniffing urine: a step forward in early diagnosis. Eur Urol. 2011;59:197–201.PubMedCrossRefGoogle Scholar
  43. 43.
    Sonoda H, Kohnoe S, Yamazato T, et al. Colorectal cancer screening with odour material by canine scent detection. Gut. 2011;60:814–9.Google Scholar
  44. 44.
    Horvath G, Chilo J, Lindblad T. Different volatile signals emitted by human ovarian carcinoma and healthy tissue. Future Oncol. 2010;6:1043–9.PubMedCrossRefGoogle Scholar
  45. 45.
    Horvath G, Andersson H, Paulsson G. Characteristic odour in the blood reveals ovarian carcinoma. BMC Cancer. 2010;10:643.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Dawn A. Marcus
    • 1
  1. 1.Department of AnesthesiologyUniversity of PittsburghPittsburghUSA

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