Antioxidants in ICSI

  • Nicolas GarridoEmail author
  • Sandra García-Herrero
  • Laura Romany
  • José Remohí
  • Antonio Pellicer
  • Marcos Meseguer


Male factor infertility can be caused by reasons, either related or not with total sperm production. Among causes of male infertility in cases of normal sperm count and motility, oxidative stress is one of the most relevant processes influencing fertility in vivo or in assisted reproduction treatments’ results. This chapter provides the most updated information regarding the oxidative stress situation in sperm and the relevance of antioxidants use in intracytoplasmic sperm injection results.


Sperm Oxidative stress ICSI DNA oxidation DNA fragmentation Antioxidant Male factor infertility Intracytoplasmic sperm injection Free radicals 



The authors want to acknowledge all the staff of IVI Valencia, in both the IVF and Andrology laboratory for their support in the research projects during the recent years, especially for the lab technicians.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Nicolas Garrido
    • 1
    Email author
  • Sandra García-Herrero
    • 2
  • Laura Romany
    • 3
  • José Remohí
    • 4
    • 5
  • Antonio Pellicer
    • 4
    • 5
  • Marcos Meseguer
    • 3
  1. 1.Andrology Laboratory and Sperm BankInstituto Universitario IVI ValenciaValenciaSpain
  2. 2.IVIOMICSValenciaSpain
  3. 3.Clinical Embryology LaboratoryInstituto Universitario IVI ValenciaValenciaSpain
  4. 4.Department of Gynecology and Obstetrics, School of MedicineUniversidad de ValenciaValenciaSpain
  5. 5.Assisted Reproduction UnitInstituto Universitario IVI Valencia, Universidad de ValenciaValenciaSpain

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