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Genetic Aspects of Male Infertility

  • Orhan BukulmezEmail author
Chapter

Abstract

Genetic abnormalities may account for 15–30% of male factor infertility. Genes and genomic regulation involved in male genital tract development, gonadal development, and function including those related to spermatogenesis may be involved with male infertility. Although many of the genetic factors are still to be elucidated and many of the predicted genetic perturbations are yet to find their place for clinical applications, it is essential to appraise the current information on genetic basis of male reproductive system disorders.

Keywords

Genetics in male infertility Genomic regulation of male sexual development Sertoli cells Testis formation Hypospadias Peritubular myoid cells Spermatogenic genes Male genital tract development Spermatogenesis 

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and GynecologyUniversity of Texas Southwestern Medical CenterDallasUSA

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